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61.
We describe two full-term infants who presented with congenital cutaneous candidiasis (CCC) and compare their clinical presentation and outcome with that of neonatal candidiasis and chronic mucocutaneous candidiasis. Although candidal vulvovaginitis occurs in up to one-third of pregnancies, CCC is uncommon and can be confused with more-serious pustular disorders that present in neonates. Greater awareness of CCC is essential to make an early diagnosis and distinguish it from other infections. 相似文献
62.
Prospective study of perioperative factors predicting hypocalcemia after thyroid and parathyroid surgery 总被引:4,自引:0,他引:4
Chia SH Weisman RA Tieu D Kelly C Dillmann WH Orloff LA 《Archives of otolaryngology--head & neck surgery》2006,132(1):41-45
OBJECTIVE: To identify whether perioperative 1,25-dihydroxyvitamin D or parathyroid hormone (PTH) levels will predict the development of hypocalcemia after thyroid and parathyroid surgery. DESIGN: Prospective study. SETTING: University hospital. PATIENTS: The study included 103 patients who underwent thyroid or parathyroid surgery between 2002 and 2004, with a comparison of the patients who underwent thyroid lobectomy (TL; n = 34), total thyroidectomy (TT; n = 27), parathyroid adenoma excision (PAE; n = 34), and subtotal parathyroidectomy for hyperplasia (SP; n = 8). MAIN OUTCOME MEASURES: Preoperative 1,25-dihydroxyvitamin D levels, number of patients requiring calcium replacement, and postoperative PTH and calcium levels. RESULTS: No patients in the TL or PAE group developed postoperative hypocalcemia that required calcium replacement. Six patients (22%) in the TT group and 3 patients (38%) in the SP group required calcium replacement for clinically significant hypocalcemia (P<.001). All patients who required calcium replacement had PTH levels of less than 15 pg/mL (1.6 pmol/L) 8 hours after surgery. Among the patients with postoperative PTH levels of less than 15 pg/mL (1.6 pmol/L) 8 hours after surgery, no patients in the PAE group required calcium replacement, compared with 75% of patients in the TT and SP groups (P<.001). The patients in the TT group had significantly lower postoperative calcium levels than those in the TL (P<.001) or the PAE (P<.005) group. The patients in the TL group reached stable calcium levels significantly earlier than those in the other groups (15.8 hours after surgery; P<.05). There was no relationship between preoperative 1,25-dihydroxyvitamin D levels and postoperative calcium levels. CONCLUSIONS: Preoperative 1,25-dihydroxyvitamin D levels were not predictive of postoperative calcium levels. Patients who undergo PAE or TL are at extremely low risk for requiring calcium replacement. Patients who undergo TT or SP with 8-hour postoperative PTH levels greater than or equal to 15 pg/mL (1.6 pmol/L) are at low risk for developing postoperative hypocalcemia, whereas those with PTH levels less than 15 pg/mL (1.6 pmol/L) have a high risk of developing hypocalcemia. 相似文献
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Vivek Kumbhari Irene Peñas Alan H. Tieu Carlos De la Serna-Higuera Manie Juneja Fuad Maufa Saowanee Ngamruengphong Mohamad H. El-Zein Nadim Haddad Sandeep Krishnan Susana Gonzalez Peter V. Renny Payal Saxena Linda Howard Christopher J. DiMaio Jonathan M. Buscaglia Manuel Perez-Miranda Mouen A. Khashab 《Digestive diseases and sciences》2016,61(12):3552-3559
67.
John C. Landefeld Christine Miaskowski Lina Tieu Claudia Ponath Christopher T. Lee David Guzman Margot Kushel 《The journal of pain》2017,18(9):1036-1045
Individuals experiencing homelessness in the United States are aging; little is known about chronic pain in this population. In a cross-sectional, population-based study, we interviewed 350 homeless individuals aged 50 years and older to describe pain experienced by older persons experiencing homelessness and to assess factors associated with chronic moderate to severe pain, defined as pain lasting ≥3 months, with a past week average severity score of 5 to 10 (scale 0–10). The median age of participants was 58 years. Participants were predominantly African American (79.6%) and male (77.3%). Overall, 46.8% reported chronic moderate to severe pain. Almost half of participants reported a diagnosis of arthritis (44.3%) and one-third reported symptoms consistent with post-traumatic stress disorder (PTSD; 32.8%). Three-quarters (75.3%) endorsed a personal history of abuse. In multivariate analyses, PTSD (adjusted odds ratio [AOR]: 2.2, 95% confidence interval [CI], 1.4–3.7), arthritis (AOR: 4.8, 95% CI, 3.0–7.8), and history of experiencing abuse (AOR: 2.4, 95% CI, 1.3–4.3) were associated with chronic moderate to severe pain. HIV status, diabetes, depressive symptoms, and substance use were not associated with pain. Clinicians should consider the management of associated mental health conditions and the sequelae of experiencing abuse in the treatment of chronic pain in older adults experiencing homelessness.
Perspective
This article describes the prevalence and factors associated with chronic pain in older homeless adults. Almost half report chronic pain, which was associated with PTSD, arthritis, and personal history of abuse. Clinicians should address chronic pain, trauma, and the associated mental health conditions in this high-risk population. 相似文献68.
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration 总被引:29,自引:0,他引:29
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Teismann P Tieu K Choi DK Wu DC Naini A Hunot S Vila M Jackson-Lewis V Przedborski S 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(9):5473-5478
Parkinson's disease (PD) is a neurodegenerative disorder of uncertain pathogenesis characterized by the loss of the nigrostriatal dopaminergic neurons, which can be modeled by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Increased expression of cyclooxygenase type 2 (COX-2) and production of prostaglandin E(2) have been implicated in neurodegeneration in several pathological settings. Here we show that COX-2, the rate-limiting enzyme in prostaglandin E(2) synthesis, is up-regulated in brain dopaminergic neurons of both PD and MPTP mice. COX-2 induction occurs through a JNKc-Jun-dependent mechanism after MPTP administration. We demonstrate that targeting COX-2 does not protect against MPTP-induced dopaminergic neurodegeneration by mitigating inflammation. Instead, we provide evidence that COX-2 inhibition prevents the formation of the oxidant species dopamine-quinone, which has been implicated in the pathogenesis of PD. This study supports a critical role for COX-2 in both the pathogenesis and selectivity of the PD neurodegenerative process. Because of the safety record of the COX-2 inhibitors, and their ability to penetrate the blood-brain barrier, these drugs may be therapies for PD. 相似文献
69.
Budd-Chiari Syndrome Complicating Metastatic Ocular Melanoma in a Patient Not Receiving Chemotherapy
James G. Caya M.D. Michael Spivey M.D. Tim M. Tieu M.D. Richard Hansen M.D. Nancy J. Wollenberg B.S. 《The American journal of gastroenterology》1983,78(12):826-829
The authors report a case of malignant melanoma associated with Budd-Chiari syndrome, that is unique for two reasons; the malignant melanoma metastases arose from an ocular primary site and the patient had not been treated with antimetabolite therapy. A review of neoplasms associated with Budd-Chiari syndrome accompanies the case report. 相似文献
70.
Lina Tieu Urmimala Sarkar Dean Schillinger James D Ralston Neda Ratanawongsa Rena Pasick Courtney R Lyles 《Journal of medical Internet research》2015,17(12)