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Background
Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer.Methods
Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves.Results
The sarcopenic group (n?=?127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n?=?46). There were no differences in morbidity or mortality between the groups (p?=?.75 and p?=?.31, respectively). Mean length of stay was similar (p?=?.70). Disease free and overall survival were similar (p?=?.20 and p?=?.39, respectively).Conclusion
There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors. 相似文献The objectives of this study were to determine the absolute bioavailability of lesinurad and to characterized its disposition in humans.
The oral bioavailability assessment was performed using a clinical design of simultaneous dosing of a therapeutic oral dose of lesinurad with an intravenous infusion of [14C]lesinurad microdose. The bioavailability of lesinurad was determined to be 100%.
The disposition of lesinurad in humans involves hepatic oxidation and renal elimination following administration of oral [14C]lesinurad dose.
Metabolism of lesinurad occurred post-systemically with low circulating levels of metabolites <3% of total radioactivity as 74.2% of total radioactivity was attributed to lesinurad.
In vitro metabolism studies identified CYP2C9 as the predominant isoform, and summation of metabolites indicated that it was responsible for ~50% of metabolism.