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Natalie Ngoi Soo-Chin Lee Mikael Hartman Lay-Wai Khin Andrea Wong 《Breast (Edinburgh, Scotland)》2013,22(1):47-52
The perspectives of patients and healthcare professionals towards breast cancer genetic tests that are becoming increasingly available is unexplored in Asians. We surveyed the interest and attitudes of 200 breast cancer patients, 67 cancer physicians, 485 medical students and cancer researchers towards three genetic tests, BRCA1/2 mutation, CYP2D6 genotype and Oncotype DX testing, using hypothetical scenarios. Approximately 60% of patients expressed initial interest in each genetic test, although the majority reversed their decisions once test limitations were conveyed, with <15% maintaining interest in each test. Cancer physicians were most likely to recommend BRCA1/2 mutation testing (73%) and least likely to recommend CYP2D6 genotyping (12%), while patients were more likely to choose Oncotype DX testing (28%) over CYP2D6 (21%) and BRCA1/2 testing (15%). Cost concerns, low educational level and lack of prior awareness of genetic testing were the main barriers against breast cancer genetic testing among Asian patients. 相似文献
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Amber Mehmood Zaw Maung Rafael J. Consunji Ayman El-Menyar Ruben Peralta Hassan Al-Thani Adnan A. Hyder 《Journal of occupational medicine and toxicology (London, England)》2018,13(1):29
Work related injuries (WRIs) are a growing public health concern that remains under-recognized, inadequately addressed and largely unmeasured in low and middle-income countries (LMIC’s). However, even in high-income countries, such as those in Gulf Cooperating Council (GCC) like Qatar, there are challenges in assuring the health and safety of its labor population. Countries in the GCC have been rapidly developing as a result of the economic boom from the petrochemical industry during the early seventies. Economic prosperity has propelled the migration of workers from less developed countries to make up for the human resource deficiency to develop its infrastructure, service and hospitality industries. Although these countries have gradually made huge gains in health, economy and human development index, including improvements in life expectancy, education, and standard of living, there remains a high incidence of work-related injuries especially in jobs in the construction and petrochemical sector. Currently, there is scarcity of literature on work-related injuries, especially empirical studies documenting the burden, characteristics and risk factors of work injuries and the work injured population, which includes large numbers of migrant workers in many GCC countries. This paper will focus on the current understanding of WRIs in those countries and identify the gaps in current approaches to workplace injury prevention, outlining current status of WRI prevention efforts in Qatar, and propose a framework of concerted action by multi-sectoral engagement. 相似文献
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Xiao-Ku Ran Khin Khin Win Aung Jun Bai Pei-Yuan Dou Zheng Zeng 《Journal of Asian natural products research》2018,20(6):538-544
The chemical constituents of 95% EtOH extract of yacon leaves were separated to yield two new sesquiterpene lactones, together with three known compounds. The two new compounds were characterized to be 8β-angeloyloxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (1) and 8β-(3-methylbut-2-enoyl) oxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (2) on the basis of NMR spectra, HR-MS and other spectroscopic methods. The cytotoxicity of compounds 1–5 were evaluated on human hepatoma cell Bel-7402 and all the compounds showed moderate cytotoxicity. 相似文献
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The success rates of craniofacial osseointegrated implants are not uniform throughout the craniofacial area. A better understanding of their clinical behaviour is needed. This article investigates current perspectives on the application of endosseous implants in the restoration of craniofacial defects. An online search was completed for the time period from 1966 to 2007, along with a manual search, to locate relevant peer-reviewed articles and textbooks published in English. A review of published reports of craniofacial application of endosseous implants in irradiated and nonirradiated tissue sites showed a strong correlation between anatomic sites and clinical success. Maxillofacial prosthetic considerations are also reviewed. 相似文献
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Tseng William W. Swallow Carol J. Strauss Dirk C. Bonvalot Sylvie Rutkowski Piotr Ford Samuel J. Gonzalez Ricardo J. Gladdy Rebecca A. Gyorki David E. Fairweather Mark Lee Kyo Won Albertsmeier Markus van Houdt Winan J. Fau Magalie Nessim Carolyn Grignani Giovanni Cardona Kenneth Quagliuolo Vittorio Grignol Valerie Farma Jeffrey M. Pennacchioli Elisabetta Fiore Marco Hayes Andrew Tzanis Dimitri Skoczylas Jacek Almond Max L. Mullinax John E. Johnston Wendy Snow Hayden Haas Rick L. Callegaro Dario Smith Myles J. Bouhadiba Toufik Desai Anant Voss Rachel Sanfilippo Roberta Jones Robin L. Baldini Elizabeth H. Wagner Andrew J. Catton Charles N. Stacchiotti Silvia Thway Khin Roland Christina L. Raut Chandrajit P. Gronchi Alessandro 《Annals of surgical oncology》2022,29(12):7335-7348
Annals of Surgical Oncology - Surgery is the mainstay of treatment for retroperitoneal sarcoma (RPS), but local recurrence is common. Biologic behavior and recurrence patterns differ significantly... 相似文献
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