全文获取类型
收费全文 | 1835篇 |
免费 | 162篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 114篇 |
妇产科学 | 26篇 |
基础医学 | 309篇 |
口腔科学 | 104篇 |
临床医学 | 190篇 |
内科学 | 267篇 |
皮肤病学 | 43篇 |
神经病学 | 92篇 |
特种医学 | 225篇 |
外科学 | 154篇 |
综合类 | 50篇 |
预防医学 | 169篇 |
眼科学 | 84篇 |
药学 | 70篇 |
中国医学 | 1篇 |
肿瘤学 | 100篇 |
出版年
2021年 | 27篇 |
2020年 | 13篇 |
2019年 | 23篇 |
2018年 | 36篇 |
2017年 | 18篇 |
2016年 | 37篇 |
2015年 | 44篇 |
2014年 | 55篇 |
2013年 | 60篇 |
2012年 | 68篇 |
2011年 | 60篇 |
2010年 | 66篇 |
2009年 | 66篇 |
2008年 | 61篇 |
2007年 | 82篇 |
2006年 | 58篇 |
2005年 | 50篇 |
2004年 | 49篇 |
2003年 | 48篇 |
2002年 | 41篇 |
2001年 | 40篇 |
2000年 | 42篇 |
1999年 | 29篇 |
1998年 | 53篇 |
1997年 | 49篇 |
1996年 | 59篇 |
1995年 | 52篇 |
1994年 | 31篇 |
1993年 | 42篇 |
1992年 | 48篇 |
1991年 | 29篇 |
1990年 | 31篇 |
1989年 | 45篇 |
1988年 | 47篇 |
1987年 | 42篇 |
1986年 | 44篇 |
1985年 | 47篇 |
1984年 | 28篇 |
1983年 | 27篇 |
1982年 | 19篇 |
1981年 | 21篇 |
1980年 | 10篇 |
1979年 | 15篇 |
1978年 | 8篇 |
1977年 | 14篇 |
1976年 | 15篇 |
1975年 | 11篇 |
1974年 | 9篇 |
1972年 | 7篇 |
1968年 | 7篇 |
排序方式: 共有2005条查询结果,搜索用时 140 毫秒
41.
JP Bound PW Harvey BJ Francis F Awwad AC Gatrell 《Archives of disease in childhood》1997,76(2):107-112
OBJECTIVE: To analyse the prevalence of neural tube defects in small geographical areas and seek to explain any spatial variations with reference to environmental lead and deprivation. SETTING: The Fylde of Lancashire in the north west of England. DESIGN: Cases were ascertained as part of a prospective survey of major congenital malformations in babies born in the Fylde to residents there between 1957 and 1981. A matched case-control analysis used infants with cardiovascular system, alimentary tract, and urinary system malformations as controls. Conditional logistic regression was used to assess the effects of more than 10 micrograms/l lead in drinking water and the Townsend deprivation score. RESULTS: The prevalence of neural tube defects in 1957-73 was higher in Blackpool, Fleetwood, and North Fylde, whereas the three control groups showed no significant spatial variation. In 1957-81 mothers living in electoral wards with either a higher proportion of houses with more than 10 micrograms/l lead in the water or a higher deprivation score had a greater risk of having a baby with a neural tube defect. For spina bifida and cranium bifidum alone, this was also true. For anencephaly, deprivation was less important although the effect of lead was still seen. In some neural tube defects, lead may act independently of other possible factors associated with deprivation. It seemed unlikely that lead levels changed significantly during the survey. The percentage of houses with 10 micrograms/l or more of lead in the water in 1984-5 was similar to that found in Great Britain 10 years previously. CONCLUSION: There is evidence to suggest that lead is one cause of neural tube defects, especially anencephaly. This could link the known preventive actions of hard water and folic acid. Calcium is a toxicological antagonist of lead. One cause of a deficiency of folic acid is impaired absorption secondary to zinc deficiency, which may be produced or exacerbated by lead. 相似文献
42.
FJ O'Callaghan AC Clarke H Joffe B Keeton R Martin A Salmon RD Thomas JP Osborne 《Archives of disease in childhood》1998,78(2):159-162
This report highlights the association between tuberous sclerosis and Wolff-Parkinson-White syndrome. Ten patients with concurrent diagnoses of Wolff-Parkinson-White syndrome and tuberous sclerosis were identified. Wolff-Parkinson-White syndrome presented early in life, nine cases being diagnosed in the first year. Eight of the 10 cases were male. In eight cases, the syndrome was associated with supraventricular tachycardias, and in nine with cardiac rhabdomyomata. One child died from cardiac failure secondary to obstruction of the left ventricular outflow tract by a rhabdomyoma. Five of nine survivors showed resolution of Wolff-Parkinson-White syndrome on follow up. The accessory pathway was localised in nine patients from surface electrocardiograms: six children had left sided pathways and three had right sided pathways. 相似文献
43.
David AC Leggett Kenneth A Miles Benjamin B Kelley 《Journal of Medical Imaging and Radiation Oncology》1998,42(4):335-340
Five cases of cerebral glioma are presented here that illustrate the benefit of functional CT imaging of blood-brain barrier permeability and cerebral blood volume. Functional CT uses Patlak analysis of a single location dynamic sequence to extract physiological information that is useful clinically in the assessment of cerebral gliomas. Functional CT offers distinct advantages over other functional modalities including clearer delineation of tumour, tumour grading, measurement of tumour activity and monitoring response to therapy. 相似文献
44.
Federle MP Chezmar JL Rubin DL Weinreb JC Freeny PC Semelka RC Brown JJ Borello JA Lee JK Mattrey R Dachman AH Saini S Harmon B Fenstermacher M Pelsang RE Harms SE Mitchell DG Halford HH Anderson MW Johnson CD Francis IR Bova JG Kenney PJ Klippenstein DL Foster GS Turner DA 《Journal of magnetic resonance imaging : JMRI》2000,12(1):186-197
The short-term safety of mangafodipir trisodium (MnDPDP) injection was studied in 546 adults with known or suspected focal liver lesions. An initial contrast-enhanced computed tomography examination was followed by unenhanced magnetic resonance imaging (MRI), injection of MnDPDP (5 micromol/kg), and enhanced MRI. Adverse events were reported for 23% of the patients; most were mild to moderate in intensity, did not require treatment, and were not drug related. The most commonly reported adverse events were nausea (7%) and headache (4%). The incidence of serious adverse events was low (nine events in six patients) and not drug related. Injection-associated discomfort was reported for 69% of the patients, and the most commonly reported discomforts included heat (49%) and flushing (33%). Changes in laboratory values and vital signs were generally transient, were not clinically significant, and did not require treatment. There were no clinically significant short-term risks from exposure to MnDPDP. 相似文献
45.
46.
47.
George AC Mendes Fran?ois Caire Suzana Saleme Sanita Ponomarjova Charbel Mounayer 《Interventional neuroradiology》2015,21(2):244-248
A 72-year-old man presented with sudden right homonymous hemianopsia. Work-up imaging revealed a left occipital haematoma and an arteriovenous fistula supplied by the meningeal branches to the clivus from the left vertebral artery (VA) with a rostral venous reflux into cortical veins. A microcatheter was advanced through brainstem veins into the venous collector. A compliant balloon was placed in the left VA facing the origin of feeders. The balloon was inflated to protect the vertebrobasilar circulation from embolic migration. Onyx was injected by the transvenous catheter. Control angiogram revealed exclusion of the lesion.Informed consent was obtained from the patient. 相似文献
48.
49.
Monika Oláhová Tobias B Haack Charlotte L Alston Jessica AC Houghton Langping He Andrew AM Morris Garry K Brown Robert McFarland Zofia MA Chrzanowska-Lightowlers Robert N Lightowlers Holger Prokisch Robert W Taylor 《European journal of human genetics : EJHG》2015,23(7):935-939
Isolated mitochondrial complex IV (cytochrome c oxidase) deficiency is an important cause of mitochondrial disease in children and adults. It is genetically heterogeneous, given that both mtDNA-encoded and nuclear-encoded gene products contribute to structural components and assembly factors. Pathogenic variants within these proteins are associated with clinical variability ranging from isolated organ involvement to multisystem disease presentations. Defects in more than 10 complex IV assembly factors have been described including a recent Lebanese founder mutation in PET100 in patients presenting with Leigh syndrome. We report the clinical and molecular investigation of a patient with a fatal, neonatal-onset isolated complex IV deficiency associated with multiorgan involvement born to consanguineous, first-cousin British Asian parents. Exome sequencing revealed a homozygous truncating variant (c.142C>T, p.(Gln48*)) in the PET100 gene that results in a complete loss of enzyme activity and assembly of the holocomplex. Our report confirms PET100 mutation as an important cause of isolated complex IV deficiency outside of the Lebanese population, extending the phenotypic spectrum associated with abnormalities within this gene. 相似文献
50.
Kenney RT Yu J Guebre-Xabier M Frech SA Lambert A Heller BA Ellingsworth LR Eyles JE Williamson ED Glenn GM 《The Journal of infectious diseases》2004,190(4):774-782
BACKGROUND: Transcutaneous immunization (TCI) is a needle-free technique that delivers antigens and adjuvants to potent epidermal immune cells. To address critical unmet needs in biodefense against anthrax, we have designed a novel vaccine delivery system using a dry adhesive patch that simplifies administration and improves tolerability of a subunit anthrax vaccine. METHODS: Mice and rabbits were vaccinated with recombinant protective antigen of Bacillus anthracis and the heat-labile toxin of Escherichia coli. Serologic changes, levels of toxin-neutralizing antibodies (TNAs), and pulmonary and nodal responses were monitored in the mice. A lethal aerosolized B. anthracis challenge model was used in A/J mice, to demonstrate efficacy. RESULTS: The level of systemic immunity and protection induced by TCI was comparable to that induced by intramuscular vaccination, and peak immunity could be achieved with only 2 doses. The addition of adjuvant in the patch induced superior TNA levels, compared with injected vaccination. CONCLUSIONS: Anthrax vaccine patches stimulated robust and functional immune responses that protected against lethal challenge. Demonstration of responses in the lung suggests that a mechanism exists for protection against challenge with aerosolized anthrax spores. A formulated, pressure-sensitive, dry adhesive patch, which is stable and can be manufactured in large scale, elicited comparable immunoglobulin G and TNA responses, suggesting that an anthrax vaccine patch is feasible and should advance into clinical evaluation. 相似文献