全文获取类型
收费全文 | 7426篇 |
免费 | 356篇 |
国内免费 | 78篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 224篇 |
妇产科学 | 120篇 |
基础医学 | 854篇 |
口腔科学 | 195篇 |
临床医学 | 439篇 |
内科学 | 2261篇 |
皮肤病学 | 76篇 |
神经病学 | 548篇 |
特种医学 | 318篇 |
外科学 | 1263篇 |
综合类 | 18篇 |
预防医学 | 117篇 |
眼科学 | 86篇 |
药学 | 365篇 |
中国医学 | 17篇 |
肿瘤学 | 910篇 |
出版年
2023年 | 58篇 |
2022年 | 112篇 |
2021年 | 194篇 |
2020年 | 101篇 |
2019年 | 169篇 |
2018年 | 184篇 |
2017年 | 169篇 |
2016年 | 214篇 |
2015年 | 184篇 |
2014年 | 280篇 |
2013年 | 303篇 |
2012年 | 483篇 |
2011年 | 543篇 |
2010年 | 345篇 |
2009年 | 282篇 |
2008年 | 440篇 |
2007年 | 468篇 |
2006年 | 484篇 |
2005年 | 522篇 |
2004年 | 506篇 |
2003年 | 444篇 |
2002年 | 432篇 |
2001年 | 71篇 |
2000年 | 67篇 |
1999年 | 72篇 |
1998年 | 86篇 |
1997年 | 66篇 |
1996年 | 61篇 |
1995年 | 50篇 |
1994年 | 45篇 |
1993年 | 42篇 |
1992年 | 27篇 |
1991年 | 33篇 |
1990年 | 35篇 |
1989年 | 41篇 |
1988年 | 31篇 |
1987年 | 21篇 |
1986年 | 15篇 |
1985年 | 16篇 |
1984年 | 18篇 |
1983年 | 15篇 |
1982年 | 29篇 |
1981年 | 17篇 |
1980年 | 12篇 |
1979年 | 9篇 |
1978年 | 10篇 |
1977年 | 16篇 |
1975年 | 5篇 |
1972年 | 5篇 |
1967年 | 4篇 |
排序方式: 共有7860条查询结果,搜索用时 12 毫秒
101.
Case of chronic-phase chronic myelogenous leukemia with an abdominal hematopoietic tumor of leukemic clone origin 总被引:2,自引:0,他引:2
Sakakura M Ohishi K Nomura K Katayama N Nishii K Masuya M Nakase K Shiku H 《American journal of hematology》2004,77(2):167-170
We report a 59-year-old man with chronic myelogenous leukemia (CML) in chronic phase who presented with a large abdominal tumor. Biopsy revealed proliferation of granulocytic-, erythroid-, and megakaryocytic-lineage cells in a retroperitoneal lymph node. The BCR/ABL fusion gene was detected on a paraffin-embedded tissue section of the lymph node by double-color fluorescence in situ hybridization, indicating an extramedullary hematopoietic tumor of CML origin. This patient has achieved a complete cytogenetic response for 19 months with imatinib mesylate (STI571; Gleevec), in association with the regression of the tumor. However, the development of an extramedullary tumor in chronic-phase CML generally indicates a poor prognosis, because it commonly consists of blast proliferation and is followed by blast crisis in the marrow within a few months. This case, therefore, points to the importance of histological examination of extramedullary tumors in CML for evaluation of disease status and for therapeutic decisions. 相似文献
102.
Imazeki F Yokosuka O Fukai K Hiraide A Saisho H 《Digestive diseases and sciences》2003,48(9):1786-1792
To clarify the clinical significance of prior hepatitis B virus (HBV) infection in the development of C-viral hepatocellular carcinoma (HCC), we conducted two studies: (1) Two hundred thirty-four patients with C-viral HCC and 320 patients with C-viral chronic liver disease without HCC admitted to our hospital between 1990 and 1994 were analyzed for the association of hepatitis B core antibody (HBcAb) positivity with HCC by multivariate logistic regression analysis, and this revealed HBcAb positivity as an independent risk factor for development of HCC adjusted for age and sex. (2) Four hundred fifty-nine patients with biopsy-proven hepatitis C virus-related chronic liver disease between 1986 and 1998 were enrolled in the cohort study and followed for the development of HCC. During an average follow-up of 6.6 ± 3.3 years, HCC developed in 63 patients, 37 of 160 patients positive for HBcAb and 26 of 299 patients negative for HBcAb. Multivariate Cox proportional regression analysis showed that the incidence of HCC increased by age, advanced stage of liver fibrosis, mean alanine aminotransferase value of more than 80 IU/liter, and positivity of HBcAb. Sustained virological responders after interferon therapy revealed a reduced risk for HCC development. In conclusion, prior HBV infection was shown to be one of the independent risk factors for development of HCC in C-viral chronic liver disease. 相似文献
103.
Fuyuki Aida Souske Yamaguchi Yohei Takatori Kentaro Nagamatsu Daichi Kiyokawa Kenichi Oyaizu Hiroyuki Nishide 《Macromolecular chemistry and physics.》2015,216(18):1850-1855
A newly established catalyst system for oxygen‐oxidative polymerization of diphenyl disulfide is reported. Combination of vanadyl compounds (e.g., VO(acac)2) and triphenylmethylium tetrakis(pentafluorophenyl)borate (TrB(C6F5)4) proceeds the polymerization to give poly(1,4‐phenylene sulfide) (PPS) at 100 °C. When triphenylmethylium tetrafluoroborate (TrBF4) is applied with vanadyl tetraphenylporphyrin (VO(TPP)) or N,N′‐(ethylenebis(salicylideneaminato))oxovanadium (VO(salen)), PPS is also given via polymerization under conditions near 160 °C. Combination of the vanadyl complex and the borate affords the first protic‐acid‐free catalytic system for the polymerization of the disulfide, suggesting the overall reaction to produce PPS and H2O from O2 and protons that are eliminated from the monomer.
104.
Hypoxia‐inducible factor‐3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE‐cadherin gene 下载免费PDF全文
105.
Koh Okamoto Shuji Hatakeyama Chise Sugita Kenichi Ogura Reiko Ueda Hiroko Kouda Junko Nakata 《Journal of infection and chemotherapy》2018,24(9):759-762
Toxigenic strains of Corynebacterium diphtheriae cause the majority of respiratory diphtheria cases. However, nontoxigenic strains of C. diphtheriae can also cause diseases, and have become increasingly common. Infection that is limited to the anterior nares (nasal diphtheria) is a well-described but rare condition, even for toxigenic C. diphtheriae. We report a case involving chronic carriage of nasal diphtheria caused by nontoxigenic C. diphtheriae, as well as a review of other reported nontoxigenic C. diphtheriae cases in Japan. Mild or asymptomatic nasal diphtheria involving nontoxigenic strains, which can be the source of transmission, may be underrecognized. Our case highlights the importance of awareness regarding nontoxigenic diphtheria among clinicians, especially in the era of improved diphtheria vaccination coverage. 相似文献
106.
Kanako Terakawa Naoki Sawa Hiroki Mizuno Akinari Sekine Noriko Hayami Daisuke Ikuma Masahiro Kawada Rikako Hiramatsu Keiichi Sumida Masayuki Yamanouchi Eiko Hasegawa Tatsuya Suwabe Junichi Hoshino Keiichi Kinowaki Kenichi Ohashi Takeshi Fujii Yoshifumi Ubara 《Internal medicine (Tokyo, Japan)》2021,60(8):1237
A 74-year-old Japanese woman diagnosed with autosomal dominant polycystic kidney disease (ADPKD) was admitted to our institute for the further examination of right-side groin pain developing in the past week. The patient was diagnosed with polymyositis (PM). Diagnostic imaging showed a mass lesion measuring 8 cm and a renal stone in the right kidney. Immediately following surgical resection of the right kidney, the patient''s serum CK decreased to the normal range. A histopathological analysis showed well-differentiated squamous cell carcinoma. In conclusion, this case showed a close relationship between the occurrence of squamous cell carcinoma and the development of PM in an ADPKD patient. 相似文献
107.
Hino Hitoshi Shiomi Akio Hatakeyama Keiichi Kagawa Hiroyasu Manabe Shoichi Yamaoka Yusuke Nagashima Takeshi Ohshima Keiichi Urakami Kenichi Akiyama Yasuto Yamaguchi Ken 《Journal of gastroenterology》2022,57(7):476-485
Journal of Gastroenterology - In clinical practice, rectal cancer (RC) is classified according to tumor location. However, RC’s genetic characteristics according to tumor location remain... 相似文献
108.
Kohki Nakamura MD PhD Takehito Sasaki MD Yutaka Take MD PhD Kentaro Minami MD Mitsuho Inoue MD Chisa Asahina MD Wataru Sasaki MD Shohei Kishi MD Shingo Yoshimura MD Yoshinori Okazaki MD Hiroyuki Motoda MD PhD Katsura Niijima MD PhD Yuko Miki MD PhD Koji Goto MD PhD Kenichi Kaseno MD PhD Eiji Yamashita MD PhD Keiko Koyama MD PhD Nobusada Funabashi MD PhD Shigeto Naito MD PhD 《Journal of cardiovascular electrophysiology》2021,32(1):16-26
109.
110.
Nobuaki Hoshino Suguru Hasegawa Koya Hida Kenji Kawada Kenichi Sugihara Yoshiharu Sakai 《International journal of colorectal disease》2016,31(7):1307-1313