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101.
102.
Christopher J. Collins Fan Yi Remwilyn Dayuha Phi Duong Simon Horslen Michelle Camarata Ayse K. Coskun Roderick H.J. Houwen Tudor L. Pop Heinz Zoller Han-wook Yoo Sung Won Jung Karl H. Weiss Michael L. Schilsky Peter Ferenci Si Houn Hahn 《Gastroenterology》2021,160(7):2367-2382.e1
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103.
Emre A Ucer E Yesilcimen K Bilsel T Oz D Sayar N Terzi S Akbulut T Ersek B 《Cardiology》2006,106(4):264-269
BACKGROUND/AIMS: The timing of GpIIb/IIIa inhibitor administration may be important in achieving early epicardial and myocardial reperfusion. We evaluated the effect of early tirofiban on myocardial salvage and cardiovascular outcome in patients with acute myocardial infarction (AMI) undergoing infarct-related artery stenting. METHODS: Patients (n = 66) with a first AMI presenting <6 h from onset of symptoms were randomized to either early administration of tirofiban in the emergency room (n = 32) or later administration in the catheterization laboratory (n = 34) (tirofiban bolus dose of 10 microg/kg, followed by 0.15 microg/kg for 24 h). The primary end-point was the degree of myocardial salvage, determined by means of serial scintigraphic studies with technetium-99m sestamibi. Thirty-day major adverse cardiac events were also assessed. RESULTS: There were no significant differences in patient characteristics or in their presentation. The mean door-to-balloon time was similar in both groups (43 +/- 12 and 53 +/- 9 min, p = 0.08). The early and late treatment groups received tirofiban 18 +/- 4 and 52 +/- 10 min after admission, respectively. Angiographic analysis revealed a higher initial frequency of TIMI grade 3 flow in the early group (31% vs. 12%, p = 0.04). Procedural success was achieved in all patients. Myocardial risk area were comparable between early and late treatment groups (35.6 +/- 12.2% vs. 39.3 +/- 14.0%, p = 0.6). Scintigraphic outcomes demonstrated a significant reduction in the final infarction size (11.8 +/- 5.2% vs. 22.4 +/- 6.2%, p = 0.01), and improvement in salvage index (0.68 +/- 0.22 vs. 0.44 +/- 0.18, p = 0.003) in favor of the early tirofiban group. The thirty-day composite end-point of death, recurrent MI or rehospitalization also favored the early group (6% early, 15% late, p = 0.06). CONCLUSION: Early tirofiban administration enhanced the degree of myocardial salvage and clinical outcome in patients with AMI undergoing infarct-related artery stenting. 相似文献
104.
Kadir Desdicioglu Mehmet Ali Malas Selen Bahceci Fatma Simsek Ayse Gizem Polat 《Journal of the Anatomical Society of India》2017,66(1):37-42
Introduction
In our study, the aim was to anatomically and histologically investigate the morphometric structures of the branches involved in the sural nerve and sural nerve formation.Method
The study was conducted on 46 lower extremities of 23 fetuses which were obtained from Izmir Katip Çelebi University, Atatürk Training and Research Hospital, with ages from 18 and 32 gestational weeks, without any external pathology or anomaly. During the study period, the posterior-side skin dissection of the lower extremity was performed with the aid of a surgical dissection microscope initially, and the structures forming the sural nerve and the sural nerve were exposed and made visible. Afterwards, sections were taken from these structures for morphometric measurements and histological examination.Results
The mean values and standard deviations of morphometric measurements obtained were determined. Separately, it was determined that there was no statistical difference between right-left sides and genders in morphometric measurements (p > 0.05). The sural nerve was determined to be differentiated into 4 types as A, B, C and D according to the way the nerve branches forming sural nerve join. In addition, differing characteristics pertaining to the sural nerve and branches were determined.Discussion
We are of the opinion that the data obtained in our study will be of use to neurologists, orthopedists and clinicians engaged in this region during interventional procedures. 相似文献105.
106.
Erhan Simsek Bulent Haydardedeoglu Servet Ozden Hacivelioglu Tayfun Cok Ayse Parlakgumus Tayfun Bagis 《International journal of gynaecology and obstetrics》2008,103(2):136-139
Objective
To determine whether cervical mucus aspiration before intrauterine insemination (IUI) has any effect on clinical pregnancy rates.Method
The outcomes of 186 IUI cycles in 95 consecutive patients in whom mucus was aspired prior to IUI were compared retrospectively with those of 1057 IUI cycles in 505 women.Results
The pregnancy rate was 15.1% (28 pregnancies for 186 cycles) in the cervical mucus aspiration group and 9.9% (105 pregnancies for 1057 cycles) in the control group (P = 0.05). Mucus aspiration led to significantly increased pregnancy rates for women with unexplained infertility (24% in the aspiration group vs 9.5% in the control group; P = 0.04).Conclusion
Cervical mucus aspiration before IUI might improve clinical pregnancy rates by yet-to-be-defined mechanisms. 相似文献107.
108.
Ayse Tosun Gul Serdaroglu Muzaffer Polat Hasan Tekgul Sarenur Gokben 《Indian journal of pediatrics》2009,76(5):547-550
Objective We aimed to describe the epidemiologic, clinical, laboratory features, neuroimaging, treatment, and outcome of children with
acute disseminated encephalomyelitis in a cohort study.
Methods In this study, twelve children who were diagnosed as acute disseminated encephalomyelitis were reviewed retrospectively. All
of the cases were reevaluated with systemic and neurological examinations, serologic tests, cerebrospinal fluid investigations,
magnetic resonance imaging.
Result Their age ranged between 2.5 and 16 years. Five of the cases had initial infections. Patients presented most often with motor
deficits (75%), secondly with loss of conscious (33%), and seizures (33%). Spinal fluid abnormalities occurred in 41.6%. Cranial,
and spinal magnetic resonance imaging (MRI) revealed hyperintense signal changes mainly in basal ganglia and thalamus (58%),
cortical and subcortical areas (33) in T2 weighted images. Myelitis was determined in two cases. Six patients were treated
with steroid, and 3 were treated with intravenous immunoglobulin. Ten patients recovered completely. We observed relapse in
one case and recurrence in two cases. These cases responded well to high dose intravenous prednisolone followed by oral prednisolone
for 6 months.
Conclusion Outlook recovery is generally good in acute disseminated encephalomyelitis. Recurrence and neurological deficits are rarely
seen. Early treatment of prednisolone is one of the most important factors to determine the prognosis in this disease. 相似文献
109.
Fatih Kose Ayberk Besen Saime Paydas Mustafa Balal Gulfiliz Gonlusen Tamer Inal Ayse Dogan Mustafa Kibar 《Clinical and experimental nephrology》2010,14(1):22-27
Background
Nonsteroidal anti-inflammatory drugs act by inhibiting the rate-limiting enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2), which are important in prostanoid formation. The aim of this experimental study was to examine the effects of selective Cox-2 inhibitor, rofecoxib, with or without furosemide, on urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA), and Cox-2 expression in the renal cortex. 相似文献110.