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51.
Minoru Imoto Masayoshi Kinoshita Masahiko Nishigaki 《Macromolecular chemistry and physics.》1966,94(1):238-247
The radical mutual copolymerization of p-substituted styrenes, such as p-methoxy-, p-chloro-, p-bromo-, p-cyanostyrene, and styrene was carried out with one another at 30°C. in the dark. As initiator, azobisisobutyronitrile was used. The plots of the copolymerization rates against HAMMETT 's σ values showed no linear relationships and the concave curves were obtained therefrom. The relative reactivities of p-substituted styrenes with a definite p-substituted polystyryl radical, which were shown by the reciprocal of monomer reactivity ratio r1, were plotted against σ values and concave curves were also obtained. The relative reactivities of p-substituted polystyryl radicals with p-substituted styrene were calculated from the ratios r2 and the propagation rate constants in homopolymerization. the plots of them against σ values gave straight lines with different ρ values, according to the polarity of substituents. These results suggest that polar structures in transition state affected markedly the copolymerization rates. The effect of substituents on resonance stabilization was also quantitatively estimated. 相似文献
52.
Kazuo Sugiyama Hideo Hatanaka Tadao Nakaya Minoru Imoto 《Macromolecular chemistry and physics.》1973,165(1):163-171
A study was made of the polymerization of acrylonitrile in dimethylformamide (DMF) initiated by the binary systems of tetramethyltetrazene (TMT) and p-substituted benzyl chlorides. The polymerization rate increased linearly with the σ-constants of substituents as electron-releasing groups were introduced to the phenyl ring of benzyl chloride. In order to elucidate the initiation mechanism of the polymerization, a kinetic investigation was also undertaken of the decomposition of TMT in the presence of p-substituted benzyl chlorides in DMF. The decomposition rate was first-order in TMT and first-order in p-substituents benzyl chloride. The decomposition rate also increased with the σ constants of substituents as electron-releasing groups were introduced. On the basis of the results, the initiation mechanism for the polymerization was discussed. 相似文献
53.
Rieko Nishimura Takahiro Hasebe Shigeru Imoto K. Mukai 《Virchows Archiv : an international journal of pathology》1998,432(1):89-93
A malignant phyllodes tumour with a noninvasive ductal carcinoma component is reported. The patient was an 80-year-old Japanese
woman with a breast tumour detected by routine physical examination. A simple mastectomy was performed. The excised tumour
was 10.5×9.4×5.4 cm in size and bulged into the skin with ulceration. The macroscopic appearance was that of a phyllodes tumour.
Histologically the tumour consisted mainly of stromal components with a leaf-like structure lined by atypical ductal epithelium.
The epithelial component showed gradual evolution to intraductal papillary carcinoma in a few areas. The stromal component
was composed mainly of fibrosarcoma with areas of osteosarcoma and rhabdomyosarcoma. Neither stromal invasion of intraductal
carcinoma nor transition between the stromal and epithelial elements was seen. Three months after the operation, death occurred,
with multiple pulmonary and subcutaneous metastases. This case probably represents malignant change in both the stromal and
the epithelial components of a phyllodes tumour. Since the two elements were independent, the possibility that a phyllodes
tumour may be one of the origins of true carcinosarcoma is raised.
Received: 11 March 1997 / Accepted: 5 May 1997 相似文献
54.
Katsuhiro Komase Takeshi Haga Yasuhiro Yoshikawa Takeshi A. Sato Kazuya Yamanouchi 《Virus genes》1990,4(2):163-172
The full-length cDNA corresponding to the mRNA for the hemagglutinin (H) protein of the Yamagata-1 strain of the subacute sclerosing panencephalitis (SSPE) virus was cloned and the nucleotide sequence was determined. The mRNA corresponding to the H protein was composed of 1952 nucleotides and contained a single large open reading frame, which encoded 620 amino acids with a predicted molecular weight of 69,723. This cDNA clone expressed the H protein in Cos 7 cells, and the transfected cells showed hemadsorption. The nucleotide and amino-acid sequence homology with the Edmonston strain of MV were 98.0% and 96.6%, respectively. The deduced amino acid sequence had a single hydrophobic domain near the N-terminus that was long enough to serve as an anchor in the membrane. Five potential glycosylation sites were found on the H protein at identical positions as in the H protein of MV. Cysteine and proline were located at almost identical positions as those of the H protein of MV. In addition, monoclonal antibody study revealed that three epitopes, including the domains that were involved in the biological activities of the H protein of MV, were conserved on the Yamagata-1 strain. These results suggested that the H protein of the Yamagata-1 strain of defective SSPE virus is structurally and functionally similar to that of the Edmonston strain of MV. 相似文献
55.
Dr. H. Ogawa T. Imoto T. Hayama 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1984,54(2):349-358
Summary A total of 311 units, responsive to natural stimulation of the oral cavity, were isolated from the rostral part of the solitary tract nucleus (NTS) of rats. Of these, 169 taste neurons, activated by taste stimulation, and 142 mechanoreceptive units, exclusively sensitive to mechanical stimulation of the oral cavity, were found. Most taste units (62.3%) were also excited by mechanical stimulation. Forty-three (34.1%) of the 126 taste units examined were identified as solitario-parabrachial relay (SP) neurons by antidromic stimulation from the ipsilateral dorsal pons, while only eleven (12.6%) of the 87 mechanoreceptive units were SP neurons. Taste SP neurons could be divided into two subgroups according to their antidromic latency; the fast SP units with an antidromic latency shorter than 9 ms and slow SP units with a longer antidromic latency. These two subgroups were not differentiated in any physiological properties except that the fast SP neurons were frequently excited by sucrose. Taste neurons were classified according to the best stimulus of the four basic taste solutions to produce the largest number of discharges in each neuron. All types of taste neurons were found among the SP and non-SP neurons, but only a small number of quinine-best neurons (n = 2) were found in the SP neuron group compared to the number of quinine-best neurons in the non-SP neuron group (n = 10). A histological examination of the recording sites revealed that taste relay neurons were found at the central or dorsal part of the nucleus but mechanoreceptive relay neurons were found at the peripheral part, although relay and non-relay neurons of either class were intermingled in the nucleus.Supported by a Grant from the Ministry of Education, Science and Culture of Japan (No. 58106008) 相似文献
56.
Kazuya Kusama Mayuko Miyagawa Koichiro Ota Naoko Kuwabara Kaori Saeki Yuki Ohnishi Yasuhiro Kumaki Tomoyasu Aizawa Toyokazu Nakasone Shigemi Okamatsu Hiroaki Miyaoka Kazuhiro Tamura 《Nutrients》2021,13(1)
The androgens testosterone and dihydrotestosterone (DHT) are essential for a variety of systemic functions in mature males. Alteration of these hormones results in late-onset hypogonadism (LOH) and benign prostate hyperplasia (BPH). The fruit bodies of fungi of the genus Cordyceps have been regarded as folk medicine or health food with tonic and antifatigue effects. The extract from the fruit body of Cordyceps militaris parasitizing Samia cynthia ricini (CM) was evaluated as a novel-candidate natural product for ameliorating male andropause symptoms. To explore the effects of CM on LOH and BPH, CM was applied to rat models and cultured testicular cells and prostate cells. The concentrations of androgens in the serum and culture media were determined by ELISA. Expression of steroidogenic enzymes and androgen-related genes was evaluated by qPCR, and prostatic cell proliferation was assessed with the cell-viability assay. CM maintained the serum levels of testosterone and DHT, but inhibited testosterone-induced prostate hypertrophy. CM also increased the secretion of testosterone and DHT by primary testicular cells, with no changes in the mRNA expression of steroidogenic enzymes, but decreased the growth of prostatic cell lines. Our data suggest that CM could improve both LOH and BPH in males. 相似文献
57.
Mishima K Sawada S Tanigawa N Okuda Y Kobayashi M Koyama T 《Cardiovascular and interventional radiology》1999,22(2):155-158
Four patients were treated by placement of an expandable metallic stent (two Gianturco Z-stents, two Ultraflex stents) for malignant colorectal strictures. All four patients were able to defecate after stent placement. Stent migration was recognized in one patient. Two patients suffered from tenesmus after stent placement. 相似文献
58.
Revascularization of the hypogastric artery often tends to be neglected in aortoiliac reconstructive surgery; however, its
incomplete revascularization can result in unfavorable complications such as buttock claudication or necrosis, vascular impotence,
and colonic ischemia. Multiple vascular lesions in the abdominal aorta and bilateral iliac arteries were reconstructed using
a newly designed double bifurcated graft in five male patients. All five patients demonstrated excellent graft limb patency
and postoperative improvement of the ankle-brachial pressure index without any clinical signs of ischemia in regions of the
hypogastric artery. Thus, we conclude that an aggressive approach toward hypogastric circulation maintenance is essential
in aortoiliac reconstructive surgery. By using this double bifurcated graft, rapid and safe revascularization of the bilateral
hypogastric arteries concomitant with the external iliac or femoral arteries can be performed. 相似文献
59.
When the diaphragm is excised so wiely that the defect cannot be closed directly during an operation on either thoracic or
epigastric tumors, a reconstruction of the defect is necessary. We used harvested autologous fascia lata to reconstruct the
diaphragm in a patient undergoing a pleuropneumonectomy with a partial diaphragmatic resection for malignant mesothelioma. 相似文献