全文获取类型
收费全文 | 9897篇 |
免费 | 821篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 67篇 |
儿科学 | 383篇 |
妇产科学 | 290篇 |
基础医学 | 1352篇 |
口腔科学 | 72篇 |
临床医学 | 1362篇 |
内科学 | 1736篇 |
皮肤病学 | 113篇 |
神经病学 | 1121篇 |
特种医学 | 188篇 |
外科学 | 917篇 |
综合类 | 96篇 |
一般理论 | 15篇 |
预防医学 | 1650篇 |
眼科学 | 99篇 |
药学 | 750篇 |
中国医学 | 3篇 |
肿瘤学 | 534篇 |
出版年
2024年 | 24篇 |
2023年 | 146篇 |
2022年 | 174篇 |
2021年 | 338篇 |
2020年 | 255篇 |
2019年 | 380篇 |
2018年 | 391篇 |
2017年 | 333篇 |
2016年 | 363篇 |
2015年 | 326篇 |
2014年 | 434篇 |
2013年 | 608篇 |
2012年 | 838篇 |
2011年 | 869篇 |
2010年 | 443篇 |
2009年 | 337篇 |
2008年 | 613篇 |
2007年 | 635篇 |
2006年 | 545篇 |
2005年 | 479篇 |
2004年 | 457篇 |
2003年 | 398篇 |
2002年 | 376篇 |
2001年 | 86篇 |
2000年 | 61篇 |
1999年 | 74篇 |
1998年 | 66篇 |
1997年 | 45篇 |
1996年 | 58篇 |
1995年 | 40篇 |
1994年 | 34篇 |
1993年 | 41篇 |
1992年 | 43篇 |
1991年 | 39篇 |
1990年 | 43篇 |
1989年 | 34篇 |
1988年 | 31篇 |
1987年 | 24篇 |
1986年 | 22篇 |
1985年 | 22篇 |
1984年 | 24篇 |
1983年 | 15篇 |
1979年 | 15篇 |
1978年 | 11篇 |
1976年 | 12篇 |
1975年 | 17篇 |
1974年 | 13篇 |
1973年 | 10篇 |
1972年 | 16篇 |
1970年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
BackgroundThe Bowel Screening Wales complex polyp removal service was introduced to address variations in surgery rates for screen‐detected complex benign colorectal polyps, to improve the quality of the screening service and to make management of these polyps more equitable across Wales. Little is known about patient experiences and the potential impact on quality of life when undergoing complex polyp removal. This study is part of a wider research programme evaluating the decision‐making, pathways and outcomes from complex polyp removal.ObjectiveThis study aimed to understand experiences of having a complex polyp removed and how this may influence quality of life.DesignSemi‐structured telephone interviews were conducted, and a thematic approach was used for data analysis.Setting and ParticipantsAll participants had a complex polyp removed after a positive stool test and review by Bowel Screening Wales'' Network Multi‐Disciplinary Team.ResultsTwenty‐one participants were interviewed. Most participants had their complex polyps removed endoscopically and reported no or minor problems or negative outcomes following their procedure. For a small minority, worse problems (e.g., pain, bowel dysfunction) and negative outcomes (e.g., cancer) followed their procedures. Most participants felt supported and reassured throughout their procedures. Any physical and emotional changes to quality of life were mainly linked to procedure outcomes.DiscussionExperiences of complex polyp removal were generally positive, with minimal changes in quality of life.ConclusionsWhile most people had a positive experience of having a complex polyp removed, support initiatives, such as counselling or signposting to coping strategies, may be helpful to reduce any potential negative effects of procedures on quality of life.Patient or Public ContributionFour patient and public involvement partners provided feedback on participant materials. 相似文献
92.
Kate Wingrove Mark A. Lawrence Priscila Machado Lena D. Stephens Sarah A. McNaughton 《Nutrients》2022,14(20)
Dietary guidelines should be underpinned by high-quality evidence. Quality assessment methods that reflect traditional evidence hierarchies prioritise evidence from randomised controlled trials (RCTs). The Hierarchies of Evidence Applied to Lifestyle Medicine (HEALM) approach is an alternative quality assessment method for research questions that for practical and/or ethical reasons, cannot be answered using RCTs. The aim of this study was to investigate how the HEALM approach could be used to assess the strength of evidence on associations between dietary patterns and all-cause mortality (a research question that is difficult to answer using RCTs). Two data sources were used: an existing systematic review of dietary patterns and all-cause mortality that synthesised evidence from observational studies; and an overview of reviews that was conducted to summarise relevant evidence from mechanistic and intervention studies. A set of four criteria were developed and used in the application of HEALM. Using different datasets in combination, the strength of evidence was rated as ‘Grade B: moderate/suggestive’ or ‘Grade C: insufficient/inconclusive’. HEALM is a novel approach for integrating and assessing the strength of evidence from mechanistic, intervention, and observational studies. Further research is needed to address the practical challenges that were identified in the application of HEALM. 相似文献
93.
Supriya Sharma Anahita Kate Pragnya Rao Donthineni Sayan Basu Swapna S Shanbhag 《Indian journal of ophthalmology》2022,70(9):3203
Of the various manifestations of ocular chemical burns (OCBs), ischemia of the limbus and the peri-limbal sclera indicates poor prognosis and in severe cases threaten the integrity of the globe. Tenonplasty is a surgical procedure which involves advancing the Tenon’s capsule over the ischemic areas to provide a vascular supply and to enable migration of the conjunctival epithelium. This review aims to provide an overview of the diagnosis of limbal ischemia and its management with Tenonplasty. A literature review was conducted using the keywords “Tenonplasty,” “Tenon’s capsule,” “ocular chemical injury,” “ocular thermal injury,” “Tenon advancement,” “scleral ischemia,” and “limbal ischemia,” and outcomes were studied from seven selected articles. In addition to clinical evaluation, in vivo imaging techniques such as anterior segment optical coherence tomography angiography can provide an objective method of measuring and monitoring the ischemia and re-perfusion of the peri-limbal vasculature. Tenonplasty can be performed in eyes with acute OCBs with scleral or limbal ischemia by dissecting the Tenon’s layer from the orbit and securing it to the limbus. The indications, mechanism of action, peri-operative considerations, surgical technique, and post-operative care of Tenonplasty are discussed in detail. The average time for post-operative re-epithelization ranges from 1 to 6 months with the formation of a symblepharon being the most common complication. In conclusion, Tenonplasty is a globe-salvaging procedure in cases with severe limbal and scleral ischemia because of OCBs and has good anatomical outcomes priming the globe for subsequent re-constructive and vision-restoring surgeries. 相似文献
94.
Kate Thomson Cindy Karouta Faran Sabeti Nicola Anstice Myra Leung Tina Jong Ted Maddess Ian G. Morgan Jeremy Game Regan Ashby 《CTS Clinical and Translational Science》2022,15(11):2673
Myopia is the leading cause of low vision worldwide and can lead to significant pathological complications. Therefore, to improve patient outcomes, the field continues to develop novel interventions for this visual disorder. Accordingly, this first‐in‐human study reports on the safety profile of a novel dopamine‐based ophthalmic treatment for myopia, levodopa/carbidopa eye drops. This phase I, first‐in‐human, monocenter, placebo‐controlled, double‐blind, paired‐eye, multidose, randomized clinical trial was undertaken in healthy adult males aged 18–30 years (mean age 24.9 ± 2.7) at the University of Canberra Eye Clinic, Australia. Participants were randomly assigned to receive either a low (1.4 levodopa:0.34 carbidopa [μmoles/day], n = 14) or standard dose (2.7 levodopa:0.68 carbidopa [μmoles/day], n = 15) of levodopa/carbidopa eye drops in one eye and placebo in the fellow eye once daily for 4 weeks (28 days). Over this 4‐week trial, and after a 4‐month follow‐up visit, levodopa/carbidopa treatment had no significant effect on ocular tolerability and anterior surface integrity, visual function, ocular health, refraction/ocular biometry, and did not induce any non‐ocular adverse events. These results indicate that topical levodopa/carbidopa is safe and tolerable to the eye, paving the way for future studies on the efficacy of this novel ophthalmic formulation in the treatment of human myopia. The findings of this study have implications not only for the treatment of myopia, but in a number of other visual disorders (i.e., amblyopia, diabetic retinopathy, and age‐related macular degeneration) in which levodopa has been identified as a potential clinical intervention.Study Highlights
- WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC?
- WHAT QUESTION DID THIS STUDY ADDRESS?
- WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE?
- HOW MIGHT THIS CHANGE CLINICAL PHARMACOLOGY OR TRANSLATIONAL SCIENCE?
95.
Bennett CL Stinson TJ Lane D Amylon M Land VJ Laver JH 《Medical and pediatric oncology》2000,34(2):92-96
BACKGROUND: Growth factor use has been shown to ameliorate chemotherapy-induced neutropenia, leading to shorter hospital stays and lower use of parenteral antibiotics, two costly areas of cancer treatment. Prior reports on pediatric patients have shown evidence of cost savings in some studies, but no such evidence in others. In this study a retrospective analysis compared the costs of inpatient supportive care for pediatric patients with T-cell leukemia and advanced lymphoblastic lymphoma enrolled in a Pediatric Oncology Group trial. PROCEDURE: Patients 1-22 years of age were randomized to receive either granulocyte colony-stimulating factor (G-CSF; n = 45) or no G-CSF (n = 43) following induction and two cycles of maintenance therapy. There were no significant differences in neutropenia-related outcomes during the induction phase. During maintenance therapy, G-CSF patients had significantly fewer days to an ANC >500 cells/microl and a trend towards fewer days of hospitalization. Data on resource utilization were tabulated from case report forms. Costs were imputed from national data on hospitalization costs, average wholesale prices of pharmaceuticals, and patient billing information from a single institution. RESULTS: Total median costs of supportive care were $34,190 for patients receiving G-CSF and $28,653 for patients not receiving G-CSF (P > 0. 05 for the cost difference). Sensitivity analyses demonstrated that the total cost difference was not statistically significant, even in scenarios that included reasonable variations in estimates of the range of the length of stay, antibiotic regimen, and dosage and cost of G-CSF. CONCLUSIONS: In the setting of pediatric leukemia, the cost of growth factor may offset potential savings from shorter hospital stays or lower antibiotic use, a finding consistent with that from the Children's Cancer Study Group. 相似文献
96.
A phase 2 trial of lenvatinib (E7080) in advanced,progressive, radioiodine‐refractory,differentiated thyroid cancer: A clinical outcomes and biomarker assessment 下载免费PDF全文
Maria E. Cabanillas MD Martin Schlumberger MD Barbara Jarzab MD PhD Renato G. Martins MD Furio Pacini MD Bruce Robinson MD Judith C. McCaffrey MD Manisha H. Shah MD Donald L. Bodenner MD Duncan Topliss MD Corina Andresen MD James P. O'Brien MD Min Ren PhD Yasuhiro Funahashi PhD Roger Allison MD Rossella Elisei MD Kate Newbold MD Lisa F. Licitra MD Steven I. Sherman MD Douglas W. Ball MD 《Cancer》2015,121(16):2749-2756
97.
Kate Keenan Debra Boeldt Diane Chen Claire Coyne Radiah Donald Jeanne Duax Katherine Hart Jennifer Perrott Jennifer Strickland Barbara Danis Carri Hill Shante Davis Smita Kampani Marisha Humphries 《Journal of child psychology and psychiatry, and allied disciplines》2011,52(1):47-55
Background: Diagnostic validity of oppositional defiant and conduct disorders (ODD and CD) for preschoolers has been questioned based on concerns regarding the ability to differentiate normative, transient disruptive behavior from clinical symptoms. Data on concurrent validity have accumulated, but predictive validity is limited. Predictive validity is critical to refuting the hypothesis that diagnosing ODD and CD in young children leads to pathologizing normal behavior. ODD and CD have emerged as gateway disorders to many forms of adult psychopathology. Establishing how early we can identify symptoms and disorders that herald poor prognosis is one of the most important goals for research on etiology and prevention. Methods: Subjects were 3–5‐year‐old consecutive referrals to a child psychiatry clinic (n = 123) and demographically matched children from a pediatric clinic (n = 100). A diagnostic interview was used to assess DSM‐IV ODD and CD in a prospective follow‐up design from preschool to school age. Stability of ODD and CD diagnoses and level of impairment were tested as a function of preschool diagnosis. Results: Over 80% of preschoolers diagnosed with ODD and approximately 60% of preschoolers diagnosed with CD met criteria for the same disorder during follow‐up. Impairment over time varied significantly as a function of stability of diagnosis across three years. Conclusions: These results provide the first evidence of the predictive validity of DSM‐IV ODD and CD in clinically referred preschool children. The findings challenge the assumption that symptoms of disruptive behavior disorders that occur during the preschool period tend to be transient. 相似文献
98.
99.
Detection of HBV-DNA in liver biopsy and serum: its significance in the selection of hepatitis B patients for antiviral therapy 总被引:1,自引:0,他引:1
We have characterized the hepatitis B virus state in liver and serum of 38 HBsAg-positive chronic hepatitis patients (chronic active hepatitis (CAH), 19; chronic persistent hepatitis (CPH), 7; cirrhosis, 11; 'normal' carrier, 1) and 21 HBsAg-negative patients. Episomal HBV-DNA in liver, without detectable integrated HBV-DNA sequences, concomitant with HBV-DNA in serum was found in 19 HBeAg-positive patients (CAH, 16; CPH, 1; cirrhosis, 2). Integrated sequences were detected in 13 HBsAg-positive HBeAg-negative patients (CAH, 1; CPH, 5; cirrhosis, 7) and in 1 HBsAg-negative patient. Episomal HBV-DNA and integrated HBV-DNA sequences were observed simultaneously in 1 HBsAg-positive HBeAg-negative CPH patient and in 4 HBsAg-positive cirrhosis patients (2 HBeAg-positive, 2 HBeAg-negative). The presence of HBcAg immunofluorescence corresponded well with that of episomal HBV-DNA. Antiviral therapy is advised for HBsAg-positive chronic hepatitis patients with episomal HBV-DNA, irrespective of the presence of integrated sequences. Since the presence of episomal HBV-DNA in liver is not always accompanied by the presence of serum HBV-DNA, procedures for the selection and evaluation of patients for antiviral therapy should be extended by characterization of the HBV-DNA state in liver biopsies. 相似文献
100.
Kelly Kohut MSc Kate Morton PhD Karen Hurley PhD Lesley Turner The CanGene-CanVar Patient Reference Panel Caroline Dale Susan Eastbrook Rochelle Gold Kate Henwood Sonia Patton Reshma Punjabi Helen White Charlene Young Julie Young Elizabeth Bancroft PhD Lily Barnett MSc Sarah Cable MSc Gaya Connolly Beth Coad MSc Andrea Forman MSc Helen Hanson MBBS MD Grace Kavanaugh MSc Katherine Sahan DPhil Katie Snape MBBS PhD Bethany Torr MSc Rosalind Way Elizabeth Winchester MSc Alice Youngs MSc The International Lynch Decision Aid Stakeholder Panel Diana Eccles MB ChB MD FRCP Claire Foster PhD MSc BSc 《Health expectations》2024,27(1):e13844