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排序方式: 共有542条查询结果,搜索用时 15 毫秒
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As vasopressin receptors are found in many different tissues, vasopressin antagonists may benefit the treatment of numerous disorders. Effects of vasopressin via V1(a) and V2 receptors are closely implicated in a variety of water-retaining diseases and cardiovascular diseases, including heart failure, hyponatremia, hypertension, renal diseases, syndrome of inappropriate antidiuretic hormone secretion, cirrhosis, and ocular hypertension. Furthermore, V1(a) vasopressin antagonists might be useful in cerebral ischemia and stroke, Raynaud's disease, dysmenorrhoea and tocolytic treatment. V1(b) selective vasopressin antagonists are discussed in terms of their usefulness in the treatment of emotional and psychiatric disorders. The vaptans are vasopressin receptor antagonists with V1(a) (relcovaptan) or V2 (tolvaptan, lixivaptan, satavaptan) selectivity or non-selective activity (conivaptan). Conivaptan is the first vaptan which has been approved by the FDA for the treatment of euvolemic hyponatremia. For further indications such as congenital heart failure, studies are going on. 相似文献
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Ricks J Molnar MZ Kovesdy CP Shah A Nissenson AR Williams M Kalantar-Zadeh K 《Diabetes》2012,61(3):708-715
Previous observational studies using differing methodologies have yielded inconsistent results regarding the association between glycemic control and outcomes in diabetic patients receiving maintenance hemodialysis (MHD). We examined mortality predictability of A1C and random serum glucose over time in a contemporary cohort of 54,757 diabetic MHD patients (age 63 ± 13 years, 51% men, 30% African Americans, 19% Hispanics). Adjusted all-cause death hazard ratio (HR) for baseline A1C increments of 8.0-8.9, 9.0-9.9, and ≥10%, compared with 7.0-7.9% (reference), was 1.06 (95% CI 1.01-1.12), 1.05 (0.99-1.12), and 1.19 (1.12-1.28), respectively, and for time-averaged A1C was 1.11 (1.05-1.16), 1.36 (1.27-1.45), and 1.59 (1.46-1.72). A symmetric increase in mortality also occurred with time-averaged A1C levels in the low range (6.0-6.9%, HR 1.05 [95% CI 1.01-1.08]; 5.0-5.9%, 1.08 [1.04-1.11], and ≤5%, 1.35 [1.29-1.42]) compared with 7.0-7.9% in fully adjusted models. Adjusted all-cause death HR for time-averaged blood glucose 175-199, 200-249, 250-299, and ≥300 mg/dL, compared with 150-175 mg/dL (reference), was 1.03 (95% CI 0.99-1.07), 1.14 (1.10-1.19), 1.30 (1.23-1.37), and 1.66 (1.56-1.76), respectively. Hence, poor glycemic control (A1C ≥8% or serum glucose ≥200 mg/dL) appears to be associated with high all-cause and cardiovascular death in MHD patients. Very low glycemic levels are also associated with high mortality risk. 相似文献
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Lucas SM Sundaram CP Wolf JS Leveillee RJ Bird VG Aziz M Pautler SE Luke P Erdeljan P Baldwin DD Ebrahimi K Nadler RB Rebuck D Thomas R Lee BR Boylu U Figenshau RS Munver R Averch TD Gayed B Shalhav AL Gundeti MS Castle EP Anderson JK Duffey BG Landman J Okhunov Z Wong C Strom KH 《The Journal of urology》2012,187(2):522-527
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Ali E. Oskouei Ghadam Ali Talebi Seyed Kazem Shakouri Kamyar Ghabili 《Journal of Physical Therapy Science》2014,26(7):1017-1022
[Purpose] The aim of this study was to investigate the efficacy of neuromobilization
combined with routine physiotherapy in patients with carpal tunnel syndrome through
subjective, physical, and electrophysiological studies. [Subjects and Methods] Twenty
patients with carpal tunnel syndrome (totally 32 hands) were assigned two groups:
treatment and control groups. In both groups, patients received the routine physiotherapy.
In addition to the routine physiotherapy, patients in the treatment group received
neuromobilization. The symptoms severity scale, visual analogue scale, functional status
scale, Phalen’s sign, median nerve tension test, and median nerve distal sensory and motor
latency were assessed. [Results] There were significant improvements in the symptoms
severity scale, visual analogue scale, median nerve tension test, and Phalen’s sign in
both groups. However, the functional status scale and median nerve distal motor latency
were significantly improved only in the treatment group. [Conclusion] Neuromobilization in
combination with routine physiotherapy improves some clinical findings more effectively
than routine physiotherapy. Therefore, this combination can be used as an alternative
effective non-invasive treatment for patients with carpal tunnel syndrome.Key words: Carpal tunnel syndrome, Neuromobilization, Electrophysiological measures 相似文献
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