肺源性心脏病急性发作期免疫功能的改变

目的:观察肺源性心脏病(简称肺心病)急性发作期患者免疫功能的变化。方法:选择南华大学附属第一医院2004-11/2006-01收治慢性肺心病急性发作期患者60例为肺心病组,于急性加重期入院第2天7:00,空腹抽取静脉血,采用流式细胞仪检测T细胞亚群CD3 、CD4 、CD8 及自然杀伤细胞活性,免疫浊度法检测体液免疫指标(IgG,IgM,IgA及补体C3)。以同期60例健康体检者为对照。结果:120例是否受试者均进入结果分析。①T细胞亚群:肺心病组CD3 ,CD4 水平低于对照组(0.52±0.06,0.62±0.04;0.32±0.06,0.41±0.06;P均<0.05),CD4 /CD8 高于对照组(1.96±0.26,1.84±0.78,P<0.05)。②免疫血清指标:肺心病组IgA、补体C3及自然杀伤细胞活性低于对照组[(1.26±0.74),(2.45±0.85)g/L;(6200±217),(9960±302)mg/L;0.34±0.08,0.57±0.07;P均<0.05]。结论:肺源性心脏病急性发作期患者的细胞免疫和体液免疫功能均受损,尤以细胞免疫功能受损更突出,且与病情呈平行关系。     

Glucophot BP-"M" analyzer for blood analysis

Miniature analyzer Glucophot BP-"M", intended for express measurements of glucose concentrations in capillary blood, was tested under clinical conditions. The reference method was the hexokinase method for glucose measurements on a Spectrum 11 biochemical analyzer (Abbott); in addition, glucose measurements were carried out on a One Touch-11 glucometer (Johnson-Johnson). The results evidence that the reproducibility and correctness of glucose analysis by the Glucophot BP-"M" analyzer both in health and disease met the requirements to laboratory measurements performed by "dry" chemical methods and demonstrated its high analytical reliability.