Concentration of Immunreactive FSH, LH and Prolactin in Seminal Fluid Following i.v. Application of LH-RH and TRH

Konzentration von immunreaktivem FSH, LH und Prolactin im Ejakulat nach der i.v.-Injektion von LH-RH und TRH
Immunreaktives FSH, LH und Prolactin werden im Ejakulat nach der i.v.-lnjektion von LH-RH und TRH neben den Serumspiegeln gemessen. Die Konzentrationen der entsprechenden Hormone im Serum und Ejakulat korrelieren nicht miteinander. Nur für LH, nicht aber für FSH und PRL wird eine Abhängigkeit der Ejakulatkonzentration von dem zeitlichen Abstand zwischen Injektion des Releasing-Hormons und der Ejakulation gefunden.
Verdünnungskurven und Säulenchromatographie von Ejakulat-LH deuten darauf hin, daß es nicht identisch ist mit dem des Serums. Da im Hoden eine HCG-immunreaktive Substanz beschrieben wurde, ist es wahrscheinlich, daß sie einen Teil der gefundenen LH-Konzentrationen im Ejakulat bildet.     

A case of acanthosis nigricans—an investigative approach

A patient with acanthosis nigricans secondary to a metastatic jejunal adenocarcinoma is described. An attempt was made to define the basic epidermal defect and to examine such possible influences as somatotrophin, epidermal growth factor, intestinal peptides and insulin receptors. No evidence to support a hyperproliferative epidermal mechanism was found and the hormonal profile was normal. However, there was an increase in circulating α-MSH and this may have contributed to the pigmentation seen in this patient.     

Treatment of idiopathic oligozoospermia with tamoxifen — a randomized controlled study

There is no conclusive evidence of the usefulness of tamoxifen in the treatment of idiopathic oligozoospermia (OAT-syndrome), as it has been used mostly in uncontrolled studies. We herein report on the controlled treatment of OAT-syndrome with tamoxifen versus placebo following a randomized design. Seventy-six men with sperm counts of 2-20 x 10(6) ml-1, sperm motility of 20-50%, and sperm morphology (abnormal cells) between 50 and 80% were involved in the study. Patients with varicocele, a history of testicular maldescent or genital inflammation were excluded. Thirty-nine patients received tamoxifen (30 mg daily), 37 patients placebo. There was a statistically significant increase in the mean serum testosterone level after treatment in the tamoxifen-treated group (from 4.9 +/- 1.9 to 7.9 +/- 3.6 ng ml-1) in comparison to the placebo group (5.3 +/- 2.0 and 5.6 +/- 2.0 ng ml-1). Serum FSH levels increased slightly in the tamoxifen group (from 6.8 +/- 4.1 to 7.3 +/- 4.8 mU ml-1), but this was not statistically significant in comparison to the placebo group (from 5.9 +/- 3.9 to 5.2 +/- 3.5 mU ml-1). Serum levels of LH did not show any differences between groups. The sperm count increased during treatment from 9.3 +/- 11.7 to 11.4 +/- 13.7 x 10(6) ml-1 in the tamoxifen group and from 9.1 +/- 7.1 to 9.3 +/- 8.8 x 10(6) ml-1 in the placebo group; this difference did not reach statistical significance. The percentage of motile and abnormal sperm was not different between the two treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)     

Nekrozoospermia in Mosaic Klinefelter''s Syndrome

A patient with nekrozoospermia is presented. His clinical, andrological and endocrinological data are described. Cytogenetically a complex chromosomal mosaic of 46,XX; 46,XY; 47,XXY and 48,XXXY was found.     

Untersuchungen zur Anwendbarkeit der Sonographie in der veterinär-andrologischen Diagnostik

Zusammenfassung: Die Ultraschalltechnik kann auch in der veterinärmedizinischen Andrologie bei Bullen und Ebern wertvolle Befunde liefern und die Möglichkeiten der klini-schen Diagnostik an den äußren und inneren Geschlechtsorganen erweitern. Um das Ver-fahren bei wertvollen Vatertieren ohne Risiko für die Samenqualität einsetzen zu können, wurden mittels eines handelsüblichen Ultraschallgerätes 30 bis 120 Minuten lang beschallte Proben aus Ejakulaten von Bullen und Ebern hinsichtlich Bewegungsaktivität und mor-phologischer Integrität untersucht; es ergaben sich keine Unterschiede beim Vergleich der Ergebnisse von beschallten und unbehandelten Proben.
Summary: Practicability of the ultrasound technique for investigations of male genital organs
It is possible to use the ultrasound technique in the veterinary andrology. Important results of that method may increase the evidence of the clinical examination of the male genital organs. To make sure that no harm may effect the sperm cells, ejaculates of bulls and boars were exposed to pulsed ultrasound (5 MHz/0,140 mW) up to 120 minutes. It was confirmed that this technique has no influence on sperm cell motility and morphology.     

Primary cutaneous cryptococcosis in an immunocompromized pigeon keeper

Summary We report the case of a pigeon keeper with CD4 lymphopenia, not associated with human immunodeficiency virus infection, who developed primary cutaneous cryptococcosis at the site of a pigeon peck.