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101.
Ee-Rah Sung Wooju Jeong Sung Yul Park Won Sik Ham Young Deuk Choi Sung Joon Hong Koon Ho Rha 《Journal of robotic surgery》2009,3(1):57-60
Acquisition of the da Vinci surgical system (Intuitive Surgical, Mountain View, USA) has enabled robot-assisted surgery to
become an acceptable alternative to open radical prostatectomy (ORP). Implementation of robotics at a single institution in
Korea induced a gradual increase in the number of performances of robot-assisted laparoscopic radical prostatectomy (RALP)
to surgically treat localized prostate cancer. We analyzed the impact of robotic instrumentation on practice patterns among
urologists and explain the change in value in ORP and RALP—the standard treatment and the new approach or innovation of robotic
technology. The overall number of prostatectomies has increased over time because the number of RALPs has grown drastically
whereas the number of OPRs did not decrease during the period of evaluation. Our experience emphasizes the potential of RALP
to become the gold standard in the treatment of localized prostate cancer in various parts of the world. 相似文献
102.
103.
Suh SY Kim JW Choi CU Kim EJ Rha SW Park CG Seo HS Oh DJ 《International journal of cardiology》2007,115(2):e78-e79
Spontaneous coronary dissection is a rare cause of myocardial ischemia, myocardial infarction and sudden cardiac death. Idiopathic spontaneous coronary artery dissection (SCAD) occurs in patient without risk factors for coronary artery disease and without underlying pregnancy. We describe a case of idiopathic spontaneous coronary dissection after sleep deprivation presenting with acute myocardial infarction. A 40 year old woman presented to an emergency department with squeezing substernal chest pain lasting 1 hour following 72 h sleep deprivation due to overtime work. On admission, ECG showed no significant ST change. But the level of CK-MB and Troponin T were increased up to 77.54 ng/ml and 1.62 ng/ml, respectively. Emergent coronary angiography demonstrated a longitudinal dissection of the middle portion in the diagonal artery with TIMI III flow to the distal part of the vessel. Because the dissected vessel was too small to pass the intravascular ultrasound (IVUS) and deploy the stent, angioplasty was not performed. Under medical treatment with aspirin, clopidogrel and unfractionated heparin, conservative management was proposed; she remained free of symptom and discharged free of chest pain and in good condition. 相似文献
104.
Kim SH Kim EJ Suh SY Choi CU Kim JW Rha SW Park CG Seo HS Oh DJ 《International journal of cardiology》2007,120(3):423-425
Stent thrombosis is a feared complication of percutaneous coronary intervention, although there is a low incidence of thrombotic events following drug-eluting stent implantation. We report a case with cardiogenic shock complicated by acute myocardial infarction due to simultaneous subacute stent thrombosis occurring 3 days after implantation of two sirolimus-eluting stents in the proximal left anterior descending artery (LAD) and in the proximal right coronary artery (RCA). 相似文献
105.
Lee MS Oh YT Han WK Rha KH Choi YD Hong SJ Yang SC Kim KW 《AJR. American journal of roentgenology》2007,189(5):W264-W271
OBJECTIVE: The purpose of this article is to show the CT findings of the various postoperative changes, surgical complications, and tumor recurrence after nephron-sparing surgery for the treatment of renal tumors. CONCLUSION: Familiarity with the various postoperative changes after nephron-sparing surgery may help radiologists in differentiating these changes from tumor recurrence or surgical complications. 相似文献
106.
Joo-Hyun O Kyung-Sool Jang Ie-Ryung Yoo Sung-Hoon Kim Soo-Kyo Chung Hyung-Sun Sohn Hyung-Kyun Rha Hae-Kwan Park Yong-An Chung Jaeseung Jeong 《Korean journal of radiology》2007,8(6):458-465
Objective
The purpose of this study was to objectively assess the efficacy of superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery using Technetium (Tc)-99m-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients who underwent STA-MCA bypass surgery.Materials and Methods
Brain perfusion SPECT images obtained at baseline and after the administration of acetazolamide were reconstructed using statistical parametric mapping in 23 patients, both before and after STA-MCA bypass surgery. The clinical outcomes of the surgery were also recorded and compared with the hemodynamic changes. A voxel with an uncorrected p-value of less than 0.001 was considered to be statistically significant.Results
SPECT images of the territory supplied by the bypass graft showed an increase in both cerebrovascular flow and reserve at baseline, and the increase was significantly higher following the administration of acetazolamide. All patients showed improvement of clinical symptoms and increased blood flow to the left temporal, parietal, and frontal cortices as well as the thalamus.Conclusion
Brain SPECT effectively and objectively demonstrated the improved outcomes of STA-MCA bypass surgery, and thus may be used in postoperative analyses. 相似文献107.
Jin Soo Choi Seong-Rim Kim Yang-Whan Jeon Kweon-Haeng Lee Hyoung Kyun Rha 《Journal of clinical neuroscience》2009,16(2):295-301
We aimed to use array comparative genomic hybridization (CGH) to identify chromosomal loci that contribute to the pathogenesis of ruptured intracranial aneurysms (IAs) in a Korean population and to confirm the results using real-time polymerase chain reaction (PCR). Twenty-three patients with ruptured IAs were enrolled in this study. Array CGH revealed copy number aberrations in 19 chromosomal regions. Chromosomal gains were identified at a high frequency in regions 1p12, 4q24, 5p15.31, 5p15.33, 6p12.2, 6q22.33, 7p21.1, 9q22.1, 10q24.32, 10q26.3, 12q13.13, 17p12, 18q12.3, 18q23, 19p13.3, 20q13.33, 21q11.2, and 21q22.3, whereas chromosomal losses were identified at 15q11.2 and 22q11.21. Real-time PCR confirmed the results of the array CGH studies of the COL6A2, GRIN3B, MUC17, and PRODH genes. This is the first study to identify candidate regions by array CGH in patients with IAs. The identification of genes that may predispose an individual to the development of IAs may lead to a better understanding of the mechanism of IA formation. Multicenter studies comparing cohorts of patients of different ethnicities are needed to better understand the mechanism of IA formation. 相似文献
108.
HT Syyong HHC Yang G Trinh C Cheung KH Kuo C van Breemen 《British journal of pharmacology》2009,156(4):587-600
Background and purpose:
Uridine 5''-triphosphate (UTP) is a potent vasoconstrictor of cerebral arteries and induces Ca2+ waves in vascular smooth muscle cells (VSMCs). This study aimed to determine the mechanisms underlying UTP-induced Ca2+ waves in VSMCs of the rat basilar artery.Experimental approach:
Isometric force and intracellular Ca2+ ([Ca2+]i) were measured in endothelium-denuded rat basilar artery using wire myography and confocal microscopy respectively.Key results:
Uridine 5''-triphosphate (0.1–1000 µmol·L−1) concentration-dependently induced tonic contraction (pEC50 = 4.34 ± 0.13), associated with sustained repetitive oscillations in [Ca2+]i propagating along the length of the VSMCs as asynchronized Ca2+ waves. Inhibition of Ca2+ reuptake in sarcoplasmic reticulum (SR) by cyclopiazonic acid abolished the Ca2+ waves and resulted in a dramatic drop in tonic contraction. Nifedipine reduced the frequency of Ca2+ waves by 40% and tonic contraction by 52%, and the nifedipine-insensitive component was abolished by SKF-96365, an inhibitor of receptor- and store-operated channels, and KB-R7943, an inhibitor of reverse-mode Na+/Ca2+ exchange. Ongoing Ca2+ waves and tonic contraction were also abolished after blockade of inositol-1,4,5-triphosphate-sensitive receptors by 2-aminoethoxydiphenylborate, but not by high concentrations of ryanodine or tetracaine. However, depletion of ryanodine-sensitive SR Ca2+ stores prior to UTP stimulation prevented Ca2+ waves.Conclusions and implications:
Uridine 5''-triphosphate-induced Ca2+ waves may underlie tonic contraction and appear to be produced by repetitive cycles of regenerative Ca2+ release from the SR through inositol-1,4,5-triphosphate-sensitive receptors. Maintenance of Ca2+ waves requires SR Ca2+ reuptake from Ca2+ entry across the plasma membrane via L-type Ca2+ channels, receptor- and store-operated channels, and reverse-mode Na+/Ca2+ exchange. 相似文献109.
Denise A Castronovo Kenneth KH Chui Elena N Naumova 《Environmental health : a global access science source》2009,8(1):61
Background
Epidemiologic studies are often confounded by the human and environmental interactions that are complex and dynamic spatio-temporal processes. Hence, it is difficult to discover nuances in the data and generate pertinent hypotheses. Dynamic mapping, a method to simultaneously visualize temporal and spatial information, was introduced to elucidate such complexities. A conceptual framework for dynamic mapping regarding principles and implementation methods was proposed. 相似文献110.
Kang-Yin Chen Seung-Woon Rha Yong-Jian Li Kanhaiya L Poddar Zhe Jin Yoshiyasu Minami Lin Wang Guang-Ping Li Shigeru Saito Jae-Hyoung Park Jin-Oh Na Cheol Ung Choi Hong-Euy Lim Jin-Won Kim Eung-Ju Kim Chang-Gyu Park Hong-Seog Seo Dong-Joo Oh 《Clinical and experimental pharmacology & physiology》2009,36(11):e78-e82
1. Both peripheral arterial disease (PAD) and coronary artery spasm (CAS) are associated with endothelial dysfunction. Thus, a higher incidence of CAS may be expected in patients with PAD. In the present study, we evaluated the incidence and characteristics of CAS in patients with PAD.
2. A total of 78 patients with PAD and 241 age- and gender-matched patients without PAD who had chest pain with normal coronary appearance on coronary angiograms underwent intracoronary acetylcholine (ACh) provocation test. Acetylcholine was injected into the left coronary artery in incremental doses of 20, 50 and 100 μg/min. Significant CAS was defined as a transient > 70% luminal narrowing with concurrent chest pain and/or ST segment changes.
3. Patients with PAD had a significantly higher incidence of ACh-induced significant CAS than those without PAD (60.3 vs 34.0%, respectively P < 0.001), as well as chest pain and ST segment changes during the ACh provocation test. Patients with PAD were more sensitive to lower doses of ACh and had a higher incidence of multivessel spasm than those without PAD. Multivariable logistic analysis showed that age, current smoking, PAD and myocardial bridge were independent predictors of ACh-induced significant CAS. Moreover, of these factors, PAD was the strongest independent predictor (odds ratio 4.25; confidence interval 1.33–13.54; P = 0.014).
4. In patients with chest pain, the presence of arterial disease at another site should still push the clinician towards treating the chest pain as angina, even if the coronary anatomy is normal on a coronary angiogram. 相似文献
2. A total of 78 patients with PAD and 241 age- and gender-matched patients without PAD who had chest pain with normal coronary appearance on coronary angiograms underwent intracoronary acetylcholine (ACh) provocation test. Acetylcholine was injected into the left coronary artery in incremental doses of 20, 50 and 100 μg/min. Significant CAS was defined as a transient > 70% luminal narrowing with concurrent chest pain and/or ST segment changes.
3. Patients with PAD had a significantly higher incidence of ACh-induced significant CAS than those without PAD (60.3 vs 34.0%, respectively P < 0.001), as well as chest pain and ST segment changes during the ACh provocation test. Patients with PAD were more sensitive to lower doses of ACh and had a higher incidence of multivessel spasm than those without PAD. Multivariable logistic analysis showed that age, current smoking, PAD and myocardial bridge were independent predictors of ACh-induced significant CAS. Moreover, of these factors, PAD was the strongest independent predictor (odds ratio 4.25; confidence interval 1.33–13.54; P = 0.014).
4. In patients with chest pain, the presence of arterial disease at another site should still push the clinician towards treating the chest pain as angina, even if the coronary anatomy is normal on a coronary angiogram. 相似文献