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191.
Abstract: An 83-year-old male was admitted to our hospital complaining of hematochezia and anal pain. He was an active homosexual. His physical examination was normal except for anal pain and bloody stool which were discovered on digital examination. Serum samples showed positive antibodies to Chlamydia trachomatis (C. trachomatis) by EIA. Stool cultures were negative for pathogenic bacteria and parasites. A colonoscopy revealed multiple aphthous erosions in the rectosigmoid and ileocecal regions. The histological findings were non-granulomatous colitis with inflammatory cell infiltration and atrophy of the glands. An immunohistological staining of biopsy specimens was positive for C. trachomatis. Antibiotic therapy was an effective treatment for the symptoms. This case appears to be a nonlymphogranuloma type C. trachomatis infection to the large bowel. Ileocecal lesions have not been reported in non-lymphogranuloma type C. trachomatis colitis.  相似文献   
192.
Eosinophilic cytoplasmic inclusion bodies were observed in the midbrain, pons, medulla and spinal cord of beef cattle (Japanese Brown). The inclusion bodies, observed in 14 of 20 cases exhibiting neurological signs and in one of nine healthy cases, differed in morphology and/or staining properties from previously reported inclusion bodies in humans and animals.  相似文献   
193.
The numbers of beta-adrenergic receptors on lymphocytes in normal subjects and asthmatic patients were measured by the use of [125I]hydroxybenzylpindolol. The numbers of beta-adrenergic receptors per lymphocyte in normal subjects, drug-free asthmatics and patients taking beta-stimulants were 1146 +/- 98, 845 +/- 114 and 582 +/- 47 sites/cell (mean +/- SE), respectively. The differences were statistically significant (P less than 0.05) among these groups, while no statistically significant differences were found in dissociation constants. A 42% decrease in the number of beta-adrenergic receptors per lymphocyte after administration of 6 mg/day of terbutaline for 7 days was noted in four volunteers. There was significant correlation (r = 0.68, P less than 0.01) between the number of beta-adrenergic receptors per lymphocyte and the percentage increase in blood sugar 20 min after subcutaneous injection of 4 micrograms/kg epinephrine. There was also significant correlation (r = 0.78, P less than 0.005) between the number of beta-adrenergic receptors per lymphocyte and the respiratory threshold for acetylcholine. These results suggest that beta-blockade and bronchial hypersensitivity in asthmatic patients may in part be due to a decreased number of beta-adrenergic receptors.  相似文献   
194.
A total of 30 episodes of documented septicemia in 25 patientswith acute leukemia have been analysed to evaluate the efficacyof granulocyte transfusion therapy. Almost 90% of the septicemiawas caused by gram-negative bacteria such as Pseudomonas aeruginosa,Escherichia coli and Klebsiella pneumoniae. The results showedthat in six out of 23 episodes (26.0%) patients treated withcombination antibiotic therapy alone responded, whereas in sixout of seven episodes (85.7%) patients given granulocyte transfusionplus combination antibiotic therapy responded. The differencewas statistically significant (p < 0.05). Granulocyte transfusionwas most effective in patients with aplastic or hypoplasticmarrows who failed to recover. The infecting organisms thatdemonstrated in vitro sensitivity to none or only one of theoriginal antibiotics were not eliminated by the antibiotic therapy,while 50% of the patients who were treated with more than twoantibiotics to which the infecting organisms were sensitivewere cured. More responses were observed in the transfusiongroup. Bone marrow status, appropriate antimicrobial agents,and early initiation of transfusion appear to be very importantin producing a beneficial clinical response.  相似文献   
195.
BACKGROUND: Cyclosporin A (CyA) can suppress relapses and reduce proteinuria in frequent-relapse nephrotic syndrome (FRNS) and steroid-resistant nephrotic syndrome (SRNS). However, some patients remain resistant to CyA therapy. The purpose of the present paper was to evaluate mycophenolate mofetil (MMF) treatment in pediatric patients with CyA-resistant intractable nephrotic syndrome. METHODS: MMF therapy was given to 11 patients with FRNS who had relapse despite CyA therapy, and one patient with SRNS who had been receiving combined therapy using steroid and CyA until immediately before the start of MMF. MMF was administered at a daily dose of 750-1000 mg/m(2) in two divided doses. RESULTS: Ten of the 11 patients with FRNS were able to maintain remission. Among them, seven patients remained relapse free for 1 year, and two patients had a decrease in the frequency of relapse after initiation of MMF therapy. One patient, however, had repeated cycles of remission and relapse, and was considered resistant to MMF therapy. The total prednisolone dose during the period from month 6 to month 12 after the start of MMF therapy was significantly lower than that during the 6 month period before the start of MMF therapy. The patient with SRNS, who had not achieved remission despite CyA administration, had complete remission on MMF. No serious adverse effects were seen in any of the present patients. CONCLUSION: MMF could be useful in CyA-treatment-refractory FRNS and CyA-resistant SRNS.  相似文献   
196.
The authors present an extremely rare case of a 48-year-old female who developed repeated perianeurysmal edema at 2, 9, and 16 weeks after endovascular coil embolization for the ruptured intracranial aneurysm. Interestingly, the mechanism for this edema could be different at each time point in this case; acute thrombosis formation, chemical inflammation, and aneurysm recanalization. We have to be aware of this potential complication in the long term after endovascular coil embolization for the intracranial aneurysm, especially with large size or buried into the brain parenchyma. The clinical implications of this case are discussed with a review of the literature.  相似文献   
197.
The purpose of this study was to determine levels of leucocyte elastase and cathepsin G in the plasma of patients in various pathological states, in which plasma increases or decreases in coagulation and fibrinolytic factors were seen. Simple methods were developed to measure the leucocyte proteinases and the results were correlated with conventional assays of coagulation and fibrinolytic factors. The total number of patients and total number of plasma samples examined were 340 and 1292, respectively. No correlation was observed between the plasma levels of elastase and cathepsin G, and plasminogen, fibrinogen and leucocyte counts. There was a weak overall correlation, however, between the leucocyte proteinases and each of the four parameters: D-dimer. thrombomodulin, antithrombin III and platelet count. There was a strong correlation between leucocyte proteinases and D-dimer and thrombomodulin in those patients with plasminogen levels within the normal range. Increased D-dimer levels, as well as plasmin, may suggest that elevated leucocyte proteinases contribute to elevated fibrinolytic mechanisms in these instances.  相似文献   
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