Reversible Photo-, Thermal-, and pH-Responsive Functionalized Wood with Fluorescence Emission

A reversible photo-, thermal-, and pH-responsive high-performance functional wood with fluorescence has been prepared. The properties, structure, multi-response, fluorescence, water resistance, and corrosion resistance of original wood (ORW) and functional wood (FUW) were investigated with an X-ray photoelectron spectroscopy (XPS) spectrometer, a Fourier-transform infrared (FTIR) spectrometer, a N₂ adsorption–desorption analyzer, an atomic force microscope (AFM), tensile tests, a scanning electron microscope (SEM), an ultraviolet–visible (UV–Vis) spectrophotometer, a fluorescence spectrometer, the equilibrium swelling ratio (ESR), and corrosion tests. The results of XPS, FTIR, N₂ adsorption–desorption, and AFM exhibited that FUW was successfully prepared. Additionally, the results of the tensile test and SEM revealed that FUW had better mechanical properties than ORW, due to the filling of epoxy resin in the pores of the wood. Moreover, the UV–Vis and fluorescence spectra demonstrated that the introduction of epoxy resin induced multi-response and fluorescence functions to FUW. Furthermore, the data of ESR and corrosion test showed that the introduction of epoxy resin greatly improved the water and corrosion resistance of wood. This study provides ideas and methods for preparing novel high-performance multi-response FUW.     

血清Eotaxin及LTB4的表达水平与直肠癌围术期输血患者发生相关不良反应的关系

目的 探讨嗜酸性粒细胞趋化因子(Eotaxin)和白三烯B4(LTB4)对直肠癌围术期输血患者发生不良反应的影响.方法 研究对象为2016年6月至2019年6月确诊直肠癌并入住我院的患者,均采取输血治疗,选择发生输血反应的66例纳入观察组,同期选择未发生输血反应60例纳入对照组,总共126例,所有患者的血清Eotaxi...     

手法整复闭合穿针内固定配合外敷促愈膏治疗尺桡骨骨折

目的：观察尺桡骨骨折采用手法整复,闭合穿针内固定,配合外敷促愈膏的疗效。方法：手法整复,闭合穿针内固定配合外敷促愈膏。结果：治疗不稳定性尺桡骨骨折28例,愈后良好占88.5%。结论：此方法操作简单,创伤小,费用低,疗效好。     

Acute Kidney Injury in the Modern Era of Allogeneic Hematopoietic Stem Cell Transplantation

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原发颅内恶性畸胎瘤34例分析

目的:总结颅内恶性畸胎瘤的临床特点,探讨其诊断方法和外科治疗效果。方法：34例原发颅内恶性畸胎瘤均经手术切除和病理证实。根据患者的临床表现和神经影像学检查,确定肿瘤的生长方式;结合手术效果对临床资料进行回顾性分析。结果：34例中,有6例术前诊断为畸胎瘤;行肿瘤全切除14例,手术死亡率为32．4％。23例肿瘤呈侵袭性生长,其术后存活时间与非侵袭性生长者比较,差异有显著性（P＜0．05）。结论：颅内恶性畸胎瘤术前不易诊断,尤其是位于鞍区者;肿瘤的侵袭性生物学行为是手术治疗效果不良的主要原因;保护下丘脑、脑干功能和解除脑积水是外科治疗的关键;全面的组织病理学检查、血清及脑脊液肿瘤标志物检测是诊断和治疗的重要依据。     

Microsurgical management of primary jugular foramen meningiomas: a series of 22 cases and review of the literature

This study summarized clinical manifestations, surgical management, histological grading, and long-term outcome of jugular foramen meningiomas (JFMs). Retrospective study was performed in 22 consecutive patients with primary JFMs from January 2004 to October 2010, enrolling 10 men and 12 women with average age of 39.4 (14–57 years). The most common initial symptom is hearing disorder, followed by lower cranial nerve dysfunctions. The tumor was classified into type I (intracranial) in 1, type II (intracranial) in 15, type IV (intracranial-extracranial) in 6, and none type III (extracranial). Surgical approaches mainly included retrosigmoid in 7, far lateral in 10, and juxtacondylar in 5, with some variations. The gross total resection was achieved in 15 cases and subtotal resection in 7. Fourteen patients (63.6 %) developed new or worse neurological deficits immediately after operation, of whom 11 (78.6 %) got alleviation. Postoperatively, keeping airway patency and prevention from aspiration pneumonia is very important. Nasotracheal intubation is much more tolerated than orotracheal intubation for postoperative patient management. WHO grade 2 was found in four cases (18.2 %) and grade 3 in one. During the average time of follow-up in 83.2 months, only one (grade 3) died of tumor regrowth 20 months after surgery and radiosurgery. Five of 17 patients of grade 1 developed tumor regrowth. Radiosurgery provides a good tumor control for tumor regrowth in grade 1, or postoperative grade 2 tumor. In conclusion, JFMs has a favorable long-term overall survival; however, neurological preservation is still challenging, especially low cranial nerves.     

Upregulation of Periostin expression in the pathogenesis of ameloblastoma

Ameloblastoma(AB) is an aggressive and slow-growing tumor with high recurrence rate, which arises from odontogenic epithelium. AB mostly shows osteolytic growth, but the specific pathogenesis is not yet clear. Periostin is a considered a prominent oncogene, which was mainly produced by osteoblasts and their precursors cells, it have been proved that Periostin play an important role in bone lysis. However, the precise role of Periostin in AB progression remains unknown. In this article, the surgical specimens from cases of AB were collected, and the Periostin expression was tested and the results were analyzed for possible correlations with clinical characteristics. In addition, the proliferation、cell cycle and migration of AM-1 cells were evaluated after transfection of siPeriostin. The results showed that Periostin levels were significantly higher in patients with AB than in controls. Moreover, Periostin levels in patients with AB were significantly associated with the number of disease. Furthermore, the results suggested that Periostin expression significantly promoted the proliferation and migration, in addition to cell cycle progression of AM-1 cells. The present study demonstrated that Periostin may be important in the pathogenesis and progression of AB and indicated its potential therapeutic value.     

Aberrant alteration of vascular endothelial growth factor-family signaling in human tubal ectopic pregnancy: what is known and unknown?

More than 98% of ectopic pregnancies occur in the Fallopian tube. Because many facets of tubal ectopic pregnancy remain unclear, prediction, prevention and treatment of tubal ectopic pregnancy are still a major clinical challenge. Compelling evidence suggests that angiogenic growth factors are involved in normal and abnormal implantation. While acknowledging the importance of an intrauterine pregnancy requires the development of a local blood supply and angiogenesis, we hypothesize that the hypoxic- and estrogen-dependent regulation of vascular endothelial growth factor/placental growth factor expression, secretion, and signaling pathways that are possibly involved in the pathophysiology of tubal ectopic pregnancy. Our hypothesis may also lead to a new therapeutic strategy for women with tubal ectopic pregnancy.     

Clinical outcomes and natural history of pediatric brainstem tumors: with 33 cases follow-ups

The purpose of this study is to investigate the patient characteristics and clinical outcomes of children with pediatric brainstem glioma. Between 2004 and 2009, a total of 42 children were diagnosed with brainstem gliomas at the Neurosurgical Center of Beijing Tiantan Hospital, China. A retrospective study including the 33 patients of this cohort with complete follow-up was conducted in an attempt to better understand clinical outcomes following multidisciplinary treatment modalities for pediatric brainstem gliomas. Investigational variables including clinical presentations, anatomical distribution, radiological findings, and clinical outcomes were analyzed. Survival time difference was computed using a Kaplan–Meier method with a log-rank test between groups. The Cox proportional hazards regression model was utilized in the multivariate analysis to determine the independent prognostic factors. Overall median survival of the entire series of patients was 11 months with a 1-year actuarial survival rate of 43.6 %. In nine patients who received no treatment after diagnosis, all patients expired within 8 months with a median time of 3.5 months. On univariate analysis, the following variables including older age at diagnosis, higher Karnofsky Performance Status score at diagnosis, the lower pathological grade, surgical resection modality, increasing diagnostic latency, and focal growth pattern were associated with better survival. On multivariate analysis, only the last two variables were associated with survival advantage. Focal pediatric brainstem gliomas amenable to a surgical resection are likely to achieve a prolonged survival. Clinical trials on larger number of patients are of importance in further understanding this spectrum of devastating diseases.