Spurious hyperchloremia and decreased anion gap in a patient with dextromethorphan bromide.

Although cold syrup containing dextromethorpan bromide is widely administered, the bromism due to cold syrup has not been reported. We report a patient who had negative anion gap with hyperchloremia and conscious loss because of daily intake of cold complex syrup (containing dextromethorphan bromide 0.4 mg/ml, acetaminophen 8.33 mg/ml) for headache for 4-5 years. The bromide content in cold complex syrup resulted in serum levels of bromide that interfered with the automated analyzers for chloride content. When conscious change is due to bromism, hemodialysis instead of forced hydration and diuresis should be performed immediately. Therefore, patients with a markedly negative anion gap with hyperchloremia should be considered as having halide intoxication.     

从二尖瓣瓣环三维形态的研究探讨合理的瓣环成形术

观察１５个固定心脏标本、１２个非固定心脏标本二尖瓣瓣环三维形态，运用动态三维超声心动图重建了１１名健康成年人的二尖瓣瓣环。发现二尖瓣瓣环为非平面的“马鞍”形，在心动周期中二尖瓣瓣环始终保持着程度不同的“马鞍”形。结果认为用硬质人工二尖瓣瓣环作瓣环成形术后的某些并发症，可能与改变了二尖瓣瓣环的天然三维形态有关。     

Gd(一)台湾-客家型部分基因克隆化分离和鉴定

从两例萄糖一6一磷酸脱氢酶变异型——台湾客家型[Gd(-)Taiwan-Hakka]患者基因组DNA中,回收经EcORⅠ完全酶解的3～5 kb片段,与载体λgt10插入重组,用SMR10单菌种系统制备包装提取物,对重组的λgt10进行体外包装,构建成两个基因组基因文库。用~(32)P中标记的G6 PDcDNA成功地从文库中初选出12个阳性克隆,挑选其中4个阳性克隆再次杂交予以证实,提取其中2个克隆DNA,经限制酸酶切电泳及斑点杂交鉴定,分离到该变异型基因的插入片段,并将其克隆到M13 mP19噬菌体,完成Gd(-)Taiwan-Hakka型部价基因克隆化分离与鉴定,为DNA序列分析寻找突变部位打下基础。     

聚芳醚砜薄膜的气体透过行为

研究了一系列聚芳醚砜的Ｈ２、ＣＯ２、Ｏ２、Ｎ２和ＣＨ４气体透过性能，讨论了其气体透过的温度依赖性。与双酚Ａ聚砜（ＰＳＦ）相比，几种新型聚芳醚砜的气体透过系数和气体选择系数同时有所提高。通过聚合物的分子链段活动性和自由体积数据系列变化，讨论了气体透过速率与分子结构的关系。     

北京市房山区绝经前后妇女骨代谢情况报告

测定北京房山区１４４例绝经前后妇女桡骨骨密度值及４３例绝经妇女血清钙、雌激素、降钙素、甲状旁腺素值。结果表明：随着年龄和绝经年限的增加，骨密度值显著下降。血清钙各年龄组变化不大。雌激素、降钙素绝经后逐渐降低，甲状旁腺素明显增加，多因素回归分析提示，年龄、绝经年限、孕次、人工流产次数、服用营养补品、经济水平、雌激素、甲状旁腺素是影响骨密度的主要因素。     

Effects of Nephritis No.3 Recipe on Nitric Oxide,Nitric Oxide Synthase Secreted by Cultured Mesangial Cells in Rats and the Gene Expression of Inducible Nitric Oxide Synthase

Objective:To explore the effect of the Nephritis No.3(N-3)recipe on nitric oxide(NO),nitric oxide synthase(NOS)secreted by cultured mesangial cells(MC)and its gene expression of the in-ducible nitric oxide synthase(iNOS).Methods:The drug(nephritis No.3)-containing serum was preparedwith serum pharmacological technique,and then was applied to react on mesangial cells cultured In fetalcalf serum(FCS)and cells cultured in FCS plus lipopolysaccharide.To observe the secretion of NO andNOS and the gene expression of iNOS by means of RT-PCR.Results:Under the two kinds of culture con-ditions,the content of NO and NOS in the groups with drug-containing serum were higher than thosewithout drug-containing serum(P<0.05,P<0.01),and the expression of iNOS mRNA was up-regula-ted too.Conclusion:The N-3 could significantly promote the secretion of NO and NOS and the mRNA ex-pression of iNOS in rats.     

骨肉瘤增殖细胞核抗原（PCNA）表达及其与临床病理和预后的关系

应用单克隆抗体ＰＣ１０免疫组方法半定量分析了增殖细胞核抗原表达与５０例骨肉瘤患者预后的关系。ＰＣＮＡ阳性级者预后差，其中半定量分级与骨肉瘤术后生存期呈显著负相关。ＰＣＮＡ表达与骨肉瘤组织学分级及骨样组织分化程度相关。     

商陆属植物根有效成分含量比较

采用比色法测定并比较了国产４种商陆属ｐｈｙｔｏｌａｃｃａ植物中主要有效成分商陆总皂甙和商陆多糖的含量，结果表明多药商陆Ｐ．ｐｏｌｙａｎｄｒａ Ｂｔａ．总皂甙含量最高，达６．２４％；多糖以商陆Ｐ．ａｃｉｎｏｓａ Ｒｏｘｂ。最，１０．５７％。本实验结果为开发本属植物资提供了依据。     

性传播疾病危险人群乙型肝炎和丙型肝炎病毒感染的血清流行病学调查

通过对４３１名卖淫妇女和１０９名正常妇女ＨＢＶ和ＨＣＶ感染的血清学指标的检测、性传播有关因素的调查，发现卖淫妇女ＨＢＶ和ＨＣＶ感染中的抗－Ｈｋｃ为４３．１５％，抗－ＨＢｓ为３６．８９％，ＨＢｓＡｇ为１０．４４％，抗－ＨＣＶ为９．５１％，明显高于正常妇女；有性传播疾病者ＨＢＶ和ＨＣＶ的各项感染指标也明显高于正常妇女。卖淫妇女的抗－ＨＣＶ感染率有随年龄增长而增高的趋势，与卖淫时限长、卖淫次数多有明显差别，这表明卖淫妇女中有较严重的ＨＢＶ和ＨＣＶ感染。     

国人新生儿心脏的解剖学研究

本文对已固定的50例(男30.女20)新生儿心脏外径、重量、体积、内部结构等进行了观测,取得了有关心脏的大量数据,为年龄解剖学和临床提供资料。