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71.
S Julius A Mejia K Jones L Krause N Schork C van de Ven E Johnson J Petrin M A Sekkarie S E Kjeldsen 《Hypertension》1990,16(6):617-623
During a survey of young subjects not receiving treatment for hypertension in Tecumseh, Michigan, clinic and self-monitored blood pressures taken at home (14 readings in 7 days) were obtained in 737 subjects (387 men, 350 women, average age 31.5 years). Hypertension in the clinic was diagnosed if the clinic blood pressure exceeded 140 mm Hg systolic or 90 mm Hg diastolic. In the absence of firm criteria for what constitutes hypertension at home, subjects whose average home blood pressure was in the upper decile of the whole population were considered to have hypertension at home. By these criteria, 7.1% of the whole population had "white coat" hypertension (i.e., high clinic but not elevated home readings). The prevalence of "sustained" hypertension (i.e., high readings in the clinic and at home) was 5.1%. Subjects with white coat and sustained borderline hypertension in Tecumseh were very similar. Both groups showed, at previous examinations (at ages 5, 8, 21, and 23 years), significantly higher blood pressure readings than the normotensive subjects. As young adults (average age 33.3 years), the parents of both hypertensive groups had significantly higher blood pressure readings than the parents of normotensive subjects. Both hypertensive groups had faster heart rates, higher systemic vascular resistance, and higher minimal forearm vascular resistance. Both hypertensive groups were more overweight, had higher plasma triglycerides, insulin, and insulin/glucose ratios than normotensive subjects. The white coat hypertensive group also had lower values of high density lipoprotein than the normotensive group. White coat hypertension is a frequent condition.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
72.
Primary linitis plastica of the rectum 总被引:2,自引:0,他引:2
Dr. Julius C. Bonello M.D. Stuart H. Q. Quan M.D. Stephen S. Sternberg M.D. 《Diseases of the colon and rectum》1980,23(5):337-342
Five cases of primary linitis plastica of the rectum are presented. The clinical, radiologic, and pathologic features of the
disease are described with emphasis on the difficulty in establishing a correct preoperative diagnosis. Because the histologic
features of primary and secondary linitis plastica are indistinguishable and because secondary involvement is twice as common
as primary, it is mandatory that other sites of origin are excluded and that both the proximal and distal margins of the resected
area be free of tumor.
Read at the joint meeting of the American Society of Colon and Rectal Surgeons and the Royal Society of Medicine, London,
England, June 18 to 20, 1979. 相似文献
73.
Julius J. Friedman 《Microvascular research》1976,12(3):275-290
The effect of elevating venous pressure (ΔPv) on the transcapillary escape of albumin (QT) in control and papverinized gracilis muscles perfused at constant flow was determined by means of direct monitoring of the rate of accumulation of tissue 125I-labeled albumin radioactivity. Simultaneously, transcapillary fluid movement (FM) was assessed volumetrically. Under control isovolumetric conditions, QT = 2.25 mg/min · 100 g. In addition to causing an FM of 0.03 ml/min · 100 g · mm Hg, increasing Pv enhanced QT by 0.06 mg/min · 100 g · mm Hg. Papverinization itself decreased QT to 2.0 mg/min · 100 g and affected FM only slightly. However, the superposition of Pv elevation caused a FM of 0.008 ml/min · 100 g · mm Hg and resulted in QT increasing by 0.29 mg/min · 100 g · mm Hg. The results of this study indicate that QT is sensitive to changes in microvascular hemodynamics, and thus changes in microvascular pressure may affect FM in two ways, first by increasing the transcapillary pressure gradient and second by augmenting QT which may superimpose an oncotic adjunct to FM. 相似文献
74.
Kamsirah Jim Shamsudin Chin-Soon Phan Julius Kulip Kishio Hatai Charles Santhanaraju Vairappan 《Journal of Asian natural products research》2019,21(5):435-441
The medicinal plant, Syzygium leucoxylon or commonly known as Obah found in North Borneo was considered as traditional medicine by local committee. Two new phenolics, leucoxenols A (1) and B (2) were isolated and identified as major secondary metabolites from the leaves of S. leucoxylon. Their chemical structures were elucidated based on spectroscopic data such as NMR and HRESIMS. Furthermore, these compounds were active against selected strains of fungi. 相似文献
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Mats Julius Stensrud Maja Puchades Vidar Gundersen 《Brain structure & function》2014,219(6):1901-1912
Recently, electrophysiological evidence was given for inhibitory postsynaptic responses at dopaminergic striatal synapses. These responses were independent of the vesicular GABA transporter, VGAT, but dependent on the vesicular dopamine transporter VMAT2. The identity and the exact source of the released molecule, as well as the presence of the putative inhibitory transmitter in VMAT2 containing synaptic vesicles remain to be shown. To clarify this, in particular to determine whether GABA is responsible for the inhibitory response at dopaminergic synapses, we used the electron microscopic immunogold method to label in vivo perfusion fixed striatal tissue with antibodies recognising GABA, VGAT, VMAT2 and tyrosine hydroxylase. We show that about 13 % of tyrosine hydroxylase positive and 11 % of VMAT2 axonal terminals in the caudo-putamen contain significant labelling for GABA. Immunogold signals for tyrosine hydroxylase and VGAT was totally segregated into different pools of nerve terminals. Quantitative analyses of the distance between gold particles signalling GABA and synaptic vesicles showed that GABA was as closely associated with synaptic vesicles in tyrosine hydroxylase positive as in tyrosine hydroxylase negative nerve terminals. Likewise, in dopaminergic terminals GABA and VMAT2 immunogold particles showed a close spatial localization, strongly suggesting the presence of GABA in VMAT2 positive synaptic vesicles. Our results suggest that GABA is exocytosed together with dopamine from dopaminergic nerve terminals in the caudo-putamen through VGAT negative and VMAT2 positive synaptic vesicles. 相似文献
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