全文获取类型
收费全文 | 1568篇 |
免费 | 43篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 30篇 |
妇产科学 | 32篇 |
基础医学 | 170篇 |
口腔科学 | 33篇 |
临床医学 | 159篇 |
内科学 | 452篇 |
皮肤病学 | 6篇 |
神经病学 | 143篇 |
特种医学 | 90篇 |
外科学 | 160篇 |
综合类 | 4篇 |
预防医学 | 109篇 |
眼科学 | 33篇 |
药学 | 70篇 |
肿瘤学 | 88篇 |
出版年
2023年 | 5篇 |
2022年 | 13篇 |
2021年 | 18篇 |
2020年 | 9篇 |
2019年 | 21篇 |
2018年 | 23篇 |
2017年 | 19篇 |
2016年 | 28篇 |
2015年 | 7篇 |
2014年 | 33篇 |
2013年 | 56篇 |
2012年 | 72篇 |
2011年 | 62篇 |
2010年 | 38篇 |
2009年 | 38篇 |
2008年 | 78篇 |
2007年 | 88篇 |
2006年 | 89篇 |
2005年 | 107篇 |
2004年 | 95篇 |
2003年 | 104篇 |
2002年 | 101篇 |
2001年 | 34篇 |
2000年 | 33篇 |
1999年 | 29篇 |
1998年 | 25篇 |
1997年 | 33篇 |
1996年 | 20篇 |
1995年 | 24篇 |
1994年 | 18篇 |
1993年 | 15篇 |
1992年 | 28篇 |
1991年 | 24篇 |
1990年 | 14篇 |
1989年 | 15篇 |
1988年 | 12篇 |
1987年 | 16篇 |
1986年 | 15篇 |
1985年 | 23篇 |
1984年 | 21篇 |
1983年 | 13篇 |
1982年 | 14篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1979年 | 8篇 |
1978年 | 12篇 |
1977年 | 17篇 |
1975年 | 8篇 |
1974年 | 6篇 |
1973年 | 5篇 |
排序方式: 共有1617条查询结果,搜索用时 15 毫秒
41.
42.
Fausto Biancari Tomas Gudbjartsson Jouni Heikkinen Vesa Anttila Timo Mäkikallio Anders Jeppsson Linda Thimour-Bergström Carmelo Mignosa Antonino S. Rubino Kari Kuttila Jarmo Gunn Jan-Ola Wistbacka Kari Teittinen Kari Korpilahti Francesco Onorati Giuseppe Faggian Giulia Vinco Corrado Vassanelli Flavio Ribichini Tatu Juvonen Tomas A. Axelsson Axel F. Sigurdsson Pasi P. Karjalainen Ari Mennander Olli Kajander Markku Eskola Erkki Ilveskoski Veronica D'Oria Marisa De Feo Tuomas Kiviniemi K.E. Juhani Airaksinen 《The American journal of cardiology》2014
43.
Kirsti Kähärä Ulla Tulisalo Juhani Grönlund Kari J. Mattila 《Community mental health journal》2014,50(7):800-810
We examined the reactions of population, social and health care professionals and local politicians in the context of a narrative case of a newborn and her mother evincing postpartal mental symptoms. The results of this postal questionnaire study indicated that in assessing the urgent need for support, a significant positive association prevailed in the resident cohort with female gender, age over 50 years or being a parent. Professionals and politicians estimated that appropriate care and access to care would be obtained in the maternity and child health clinic in the local health centre. Residents would contact relatives rather than social and health care professionals. A future challenge is to promote the knowledge and sensitivity of the general population in recognizing mental symptoms in mothers with small children. Adequate information is also called for regarding local services and means of access to care. 相似文献
44.
Olli Hartiala Costan G. Magnussen Sami Kajander Juhani Knuuti Heikki Ukkonen Antti Saraste Irina Rinta-Kiikka Sakari Kainulainen Mika Kähönen Nina Hutri-Kähönen Tomi Laitinen Terho Lehtimäki Jorma S.A. Viikari Jaakko Hartiala Markus Juonala Olli T. Raitakari 《Journal of the American College of Cardiology》2012
45.
Avoranta ST Korkeila EA Syrjänen KJ Pyrhönen SO Sundström JT 《World journal of gastroenterology : WJG》2012,18(33):4549-4556
AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer.METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were analyzed.RESULTS: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as “front-positive” and in 41% as “front-negative”. The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the “front-positive” tumors.CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease. 相似文献
46.
Sanna H. Rantakömi Jari A. Laukkanen Juhani Sivenius Jussi Kauhanen Sudhir Kurl 《Journal of neurology》2013,260(2):534-539
High blood pressure and overweight are risk factors for stroke. The aim of the present study was to examine the association between alcohol consumption and the risk of stroke according to the level of blood pressure and body weight. This study is a population-based sample of men with an average follow-up of 14.9 years from eastern Finland. A total of 2,599 men with no history of stroke at baseline participated. During the follow-up period, 224 strokes occurred, of which 181 were ischemic strokes. After adjustment for age, year of examination, socioeconomic status, serum LDL cholesterol, body mass index, smoking and energy expenditure of physical activity (kcal/day), there was a significant trend of an increased risk for any and ischemic stroke among hypertensive men. Hypertensive (blood pressure of over 140/90 mm Hg) men, who did not consume alcohol had a 1.72-fold (95 % CI 1.12–2.66; p = 0.014) relative risk (RR) for any stroke and a 1.90-fold (95 % CI 1.15–3.13; p = 0.012) RR for ischemic stroke. Among hypertensive men who consumed alcohol RR was 1.86-fold (95 % CI 1.20–2.89; p = 0.005) for any stroke and 2.02-fold (95 % CI 1.21–3.35; p = 0.007) for ischemic stroke. Men who did not consume alcohol with elevated BMI (≥26.4 kg/m2) had a 1.63-fold RR (95 % CI 1.11–2.40; p = 0.013) for any stroke and a 1.33-fold RR (95 % CI 0.87–2.04; p = 0.199) for ischemic stroke after adjusting for risk factors. Overweight men (≥26.4 kg/m2) who consumed alcohol had a 1.73-fold RR (95 % CI 1.18–2.54; p = 0.005) for any stroke and a 1.71-fold RR (95 % CI 1.14–2.57; p = 0.010) for ischemic stroke after being adjusted for risk factors. In conclusion, this population-based prospective study shows that hypertensive and overweight men who consumed alcohol had an increased risk for stroke. 相似文献
47.
Juhani Ojala Jukka Vanhanen Hanna Harno Pantelis Lioumis Selja Vaalto Mari A. Kaunisto Jukka Putaala Marko Kangasniemi Erika Kirveskari Jyrki P. Mäkelä Eija Kalso 《Neuromodulation》2022,25(4):538-548
ObjectivesCentral poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2), for CPSP treatment.Materials and MethodsThis prospective, randomized, double-blind, sham-controlled three-arm crossover trial assessed navigated rTMS (nrTMS) targeted to M1 and S2 (10 sessions, 5050 pulses per session at 10 Hz). Participants were evaluated for pain, depression, anxiety, health-related quality of life, upper limb function, and three plasticity-related gene polymorphisms including Dopamine D2 Receptor (DRD2). We monitored pain intensity and interference before and during stimulations and at one month. A conditioned pain modulation test was performed using the cold pressor test. This assessed the efficacy of the descending inhibitory system, which may transmit TMS effects in pain control.ResultsWe prescreened 73 patients, screened 29, and included 21, of whom 17 completed the trial. NrTMS targeted to S2 resulted in long-term (from baseline to one-month follow-up) pain intensity reduction of ≥30% in 18% (3/17) of participants. All stimulations showed a short-term effect on pain (17–20% pain relief), with no difference between M1, S2, or sham stimulations, indicating a strong placebo effect. Only nrTMS targeted to S2 resulted in a significant long-term pain intensity reduction (15% pain relief). The cold pressor test reduced CPSP pain intensity significantly (p = 0.001), indicating functioning descending inhibitory controls. The homozygous DRD2 T/T genotype is associated with the M1 stimulation response.ConclusionsS2 is a promising nrTMS target in the treatment of CPSP. The DRD2 T/T genotype might be a biomarker for M1 nrTMS response, but this needs confirmation from a larger study. 相似文献
48.
S.P. Singh PhD Ola Ibrahim MSc Hugh J. Byrne PhD Jopi W. Mikkonen MSc Arto P. Koistinen PhD Arja M. Kullaa PhD Fiona M. Lyng PhD 《Head & neck》2016,38(Z1):E2403-E2411
Optical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed, and cost, and these label‐free, noninvasive methods have the potential to change the future workflow of cancer management. The oral cavity is particularly accessible and, thus, such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. After an introduction to the epidemiology and etiological factors associated with oral cancers currently used, diagnostic methods and their limitations are presented. A thorough review of fluorescence, infrared absorption, and Raman spectroscopic methods in oral cancer diagnosis is presented. The applicability of minimally invasive methods based on serum/saliva is also discussed. The review concludes with a discussion on future demands and scope of developments from a clinical point of view. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E2403–E2411, 2016 相似文献
49.
Pukkila M Kosunen A Ropponen K Virtaniemi J Kellokoski J Kumpulainen E Pirinen R Nuutinen J Johansson R Kosma VM 《Journal of clinical pathology》2007,60(3):267-272
BACKGROUND: Versican, an extracellular matrix proteoglycan, has been noted to be expressed in several malignant tumours and has been suggested to play an important role in cancer development and tumour growth. AIMS: To investigate whether the versican expression level in the peritumoural stromal tissue of primary oral squamous cell carcinoma (OSCC) predicts relapse-free or disease-specific survival. Also, to study the associations between versican expression and several other clinicopathological variables, as well as tumour cell proliferation. METHODS: Immunohistochemistry was used to study the expression of versican and tumour cell proliferative activity in 139 OSCCs. All pertinent clinical data were collected retrospectively from the hospital records. RESULTS: In this cohort, versican expression did not correlate with the clinicopathological factors or tumour cell proliferation. In univariate analyses, higher risk for disease recurrence was associated with higher stromal versican expression score (p = 0.02), positive neck node status (p = 0.02), lower Karnofsky performance status (p = 0.03) and higher tumour cell proliferation index (p = 0.04). Increased disease-specific risk of death was associated with high stromal versican expression score (p = 0.005) higher T class (p = 0.002), positive neck node status (p<0.001), higher stage (p<0.001), poorer histological differentiation (p = 0.005), worse general condition of the patient (p = 0.049) and increased tumour cell proliferative index (p = 0.02). In multivariate disease-specific survival analysis, high stromal versican expression score (p = 0.048), poorer histological differentiation (p = 0.047) and higher stage (p = 0.002) independently predicted poorer disease outcome. CONCLUSIONS: In this cohort, increased stromal versican expression correlated with both increased risk for disease recurrence and shortened survival. High stromal versican expression may thus be considered an independent and adverse prognostic marker in OSCC. 相似文献
50.
Jussi Nikkola Irina Rinta-Kiikka Sari Räty Johanna Laukkarinen Riitta Lappalainen-Lehto Satu Järvinen Hanna Seppänen Isto Nordback Juhani Sand 《Journal of gastrointestinal surgery》2014,18(1):164-171