全文获取类型
收费全文 | 185596篇 |
免费 | 8682篇 |
国内免费 | 491篇 |
专业分类
耳鼻咽喉 | 2500篇 |
儿科学 | 6006篇 |
妇产科学 | 5235篇 |
基础医学 | 25456篇 |
口腔科学 | 4866篇 |
临床医学 | 14320篇 |
内科学 | 41560篇 |
皮肤病学 | 5625篇 |
神经病学 | 15525篇 |
特种医学 | 4113篇 |
外国民族医学 | 31篇 |
外科学 | 22589篇 |
综合类 | 1111篇 |
一般理论 | 69篇 |
预防医学 | 19861篇 |
眼科学 | 3537篇 |
药学 | 13030篇 |
中国医学 | 539篇 |
肿瘤学 | 8796篇 |
出版年
2023年 | 985篇 |
2022年 | 1651篇 |
2021年 | 3925篇 |
2020年 | 2092篇 |
2019年 | 3914篇 |
2018年 | 5237篇 |
2017年 | 3355篇 |
2016年 | 3437篇 |
2015年 | 3807篇 |
2014年 | 5060篇 |
2013年 | 7563篇 |
2012年 | 11320篇 |
2011年 | 11609篇 |
2010年 | 6428篇 |
2009年 | 5608篇 |
2008年 | 9745篇 |
2007年 | 10154篇 |
2006年 | 9954篇 |
2005年 | 10003篇 |
2004年 | 9365篇 |
2003年 | 8766篇 |
2002年 | 8435篇 |
2001年 | 5387篇 |
2000年 | 5534篇 |
1999年 | 4668篇 |
1998年 | 1498篇 |
1997年 | 1104篇 |
1996年 | 1019篇 |
1995年 | 904篇 |
1994年 | 773篇 |
1993年 | 710篇 |
1992年 | 2375篇 |
1991年 | 2255篇 |
1990年 | 2095篇 |
1989年 | 1859篇 |
1988年 | 1706篇 |
1987年 | 1675篇 |
1986年 | 1532篇 |
1985年 | 1478篇 |
1984年 | 1149篇 |
1983年 | 972篇 |
1979年 | 1057篇 |
1978年 | 728篇 |
1975年 | 704篇 |
1974年 | 918篇 |
1973年 | 879篇 |
1972年 | 764篇 |
1971年 | 718篇 |
1970年 | 761篇 |
1969年 | 718篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
101.
OBJECTIVES: The objectives of this randomised controlled study were to determine if pre-admission patient education affects post-operative pain levels, domiciliary self-care capacity and patient recall following a laparoscopic cholecystectomy (LC). Participants were randomised to receive the standard preadmission program (SP) or an individualised, education intervention (El). DESIGN: A pre-operative questionnaire was administered in the pre-admission clinic to determine participants' knowledge of LC and post-operative management. Telephone follow-up and post-operative questionnaire were conducted approximately 14 days post discharge. SETTING: Preadmission clinic of a Sydney, Australia, tertiary referral hospital. SAMPLE: Ninety-three elective LC patients. RESULTS: EI participants experienced lower pain levels and had significantly greater recall of provided information. However, no significant differences were found between the control and intervention groups for domiciliary self-care. CONCLUSION: Pre-admission education intervention helps reduce post-operative pain levels following LC and significantly increases patients' knowledge of self-care and complication management. 相似文献
102.
103.
Hyper-IgM syndrome with CHARGE association 总被引:1,自引:0,他引:1
Pilar Bahillo Teresa Cantero Pilar Solís Paz Aragón Samuel Gómez Rosario Cambronero 《Pediatric allergy and immunology》2003,14(6):487-489
A girl with coloboma of the iris, sensorineural deafness, growth delay, distinctive face, and cranial nerve dysfunction was diagnosed of CHARGE association in the first year of life. She presented with repeated otitis. At 3 yr of age, the patient suffered a septicemia ( Streptococcus pneumoniae , Corynebacterium sp.). The immunoglobulin G (IgG) and IgA serum levels were decreased, IgM increased and cellular immunity parameters were normal, supporting the diagnosis of hyper-IgM (HIM) syndrome. The sequence of CD40 ligand and cytidine deaminase genes were normal. From then on, she was receiving immunoglobulin intravenously with an excellent outcome . Here, we report the first case of CHARGE association and HIM syndrome in the same patient. Although the cause could not be identified, a non-random link is likely. 相似文献
104.
Jose M. Fernández-Cebrián Peter Vorwald Kuborn Mar Pardo de Lama Alfonso Sanjuanbenito Dehesa Manuel Nevado Santos Pedro A. Pacheco Martínez Beatriz Fernández-Escudero 《Clinical & translational oncology》2005,7(3):101-109
Colorectal cancer is one of the best studied of all malignant diseases interms of genetics and/or molecular prognostic factors. These factors, and relationships with prognosis, may have important implications especially in the design of surgical and adjuvant chemo-radiotherapy options. However, the true prognostic significance of all known factors has yet to be realised. We have reviewed the literature with specific focus on the role of molecular markers involved in prognosis and the prediction of response to adjuvant treatment. 相似文献
105.
Robert B. Forbes David J. Murray Judith B. Dillman David L. Dull 《Journal canadien d'anesthésie》1989,36(2):160-164
Plasma methohexitone concentrations were determined in 60 children, aged one to six years, following administration of 15 mg.kg-1, 20 mg.kg-1, 25 mg.kg-1 or 30 mg.kg-1 two per cent rectal methohexitone. Time to the onset of sleep was determined by a blinded observer and venous blood samples obtained 15, 30, 45 and 120 minutes following drug administration. Fifty of 60 children were asleep within 15 minutes. Nine of the ten children that did not fall asleep were sedate and could be separated easily from their parents to undergo inhalational induction of anesthesia. Time to the onset of sleep was inversely related to the dose of rectal methohexitone administered. Sleep was achieved more reliably following the use of 25 to 30 mg.kg-1 rectal methohexitone. In addition, plasma methohexitone concentrations following 30 mg.kg-1 rectal methohexitone were significantly higher for up to 120 minutes following drug administration than the plasma concentrations achieved after 15 mg.kg-1 or 20 mg.kg-1 methohexitone. There was no difference in the incidence of complications. The authors recommend that clinical circumstances be carefully considered and the dose of rectal methohexitone administered be individualized to meet the specific anaesthetic requirements of each child. 相似文献
106.
The present study was performed in order to follow the response of astroglial cells in the rat hippocampus to chronic low-level lead exposure. The experiments combined immunohistochemistry using anti-glial fibrillary acidic protein (GFAP) antibody and conventional transmission electron microscopy (EM). Chronic administration with drinking water [1 g% w/v (subclinical dose) of lead acetate dissolved in distilled water] was started through the mother's milk when pups were 7 days old. Following weaning, experimental offspring were treated for 3 months with the same concentration of adulterated water. The group of intoxicated animals and their controls were sacrificed by perfusion-fixation at 30, 60, and 90 days of exposure. After 60 days of lead treatment, staining of GFAP-positive cells demonstrated an astroglial transformation from the quiescent to the reactive state, characterized by an increase in GFAP. In control rats no changes in GFAP immunostaining were observed. The intensity of the astroglial response was enhanced after 90 days of lead intoxication, showing an increment of GFAP immunoreactivity. Quantification of these changes was made by computerized image analysis, confirming that the sectional areas of the astroglia in lead-exposed animals were larger than those in controls. These results are consistent with the ultrastructural alterations. Simultaneously with the increment in gliofilaments, intranuclear inclusions were seen in some astrocytes. The mechanisms by which lead affects astrocytes are unknown. Probably the astroglial changes induced by lead intoxication produce microenvironmental modifications that may disturb the neuronal function. 相似文献
107.
R Mollà J M Garcia-Verdugo C López-Garcia V Martín-Perez 《Journal für Hirnforschung》1986,27(6):625-637
The neuronal morphological development of the avian telencephalic cortex (DMC) is studied in Golgi-stained brain sections. The neuronal types at embryonic days 10, 13, 16, as well as of newborn chick are identified. The immature neurons are characterized by the presence of hair-like processes, growth cones and dendritic varicosities. These characteristics are absent in neuronal types of newborn chick. There are five patterns of differentiation, which produce six neuronal types in the newborn chick: horizontal neurons, pyramidal neurons, bipyramidal neurons, short axon multipolar neurons, long axon multipolar neurons and periventricular neurons. The morphological features of migrating embryonic cells are described. The dendritic spines appear in 16-day embryos in the majority of neuronal types. 相似文献
108.
Carmen Guillén Ponce María Pilar Garrido López María José Molina Garrido Gema Muñoz Molina Alfredo Carrato 《Clinical & translational oncology》2007,9(1):53-55
Pituitary metastases of solid tumours are infrequent, specially as a first manifestation. When they happen, they are usually
due to breast or lung cancer and are asymptomatic or produce diabetes insipidus. It is very strange that they produce hormonal
deficiency.
We present a case report of a bronchogenic adenocarcinoma in a 65-year-old man which began with panhypopituitarism, diabetes
insipidus and visual alterations. Magnetic resonance imaging revealed a large sellar mass, with clivus infiltration and invading
the right cavernous sinus. The biopsy result was adenocarcinoma metastases from lung cancer. 相似文献
109.
Dónal P O'Mathúna 《BMC medical ethics》2006,7(1):2-12
Background
The justification for Nazi programs involving involuntary euthanasia, forced sterilisation, eugenics and human experimentation were strongly influenced by views about human dignity. The historical development of these views should be examined today because discussions of human worth and value are integral to medical ethics and bioethics. We should learn lessons from how human dignity came to be so distorted to avoid repetition of similar distortions. 相似文献110.