全文获取类型
收费全文 | 2679篇 |
免费 | 231篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 95篇 |
妇产科学 | 90篇 |
基础医学 | 365篇 |
口腔科学 | 31篇 |
临床医学 | 367篇 |
内科学 | 489篇 |
皮肤病学 | 28篇 |
神经病学 | 271篇 |
特种医学 | 53篇 |
外科学 | 274篇 |
综合类 | 35篇 |
一般理论 | 22篇 |
预防医学 | 350篇 |
眼科学 | 50篇 |
药学 | 193篇 |
中国医学 | 1篇 |
肿瘤学 | 189篇 |
出版年
2023年 | 45篇 |
2022年 | 54篇 |
2021年 | 113篇 |
2020年 | 67篇 |
2019年 | 89篇 |
2018年 | 76篇 |
2017年 | 70篇 |
2016年 | 80篇 |
2015年 | 79篇 |
2014年 | 106篇 |
2013年 | 138篇 |
2012年 | 188篇 |
2011年 | 172篇 |
2010年 | 93篇 |
2009年 | 104篇 |
2008年 | 157篇 |
2007年 | 191篇 |
2006年 | 159篇 |
2005年 | 186篇 |
2004年 | 145篇 |
2003年 | 132篇 |
2002年 | 110篇 |
2001年 | 17篇 |
2000年 | 17篇 |
1999年 | 27篇 |
1998年 | 27篇 |
1997年 | 18篇 |
1996年 | 14篇 |
1995年 | 16篇 |
1994年 | 14篇 |
1992年 | 6篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1988年 | 14篇 |
1987年 | 8篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 6篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1980年 | 6篇 |
1979年 | 7篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1973年 | 5篇 |
1970年 | 4篇 |
1955年 | 5篇 |
1947年 | 4篇 |
排序方式: 共有2918条查询结果,搜索用时 15 毫秒
41.
Kirsten Ebbert Josephine Chow Jennifer Krempien Mina Matsuda‐Abedini Janis Dionne 《Pediatric transplantation》2015,19(5):492-498
Vitamin D deficiency is prevalent in the pediatric CKD population. Recognizing that renal transplant recipients have CKD, we assessed the prevalence of vitamin D insufficiency and deficiency in pediatric renal transplant recipients, compared to a healthy pediatric population. We prospectively studied 25(OH)D levels in 29 pediatric renal transplant recipients and 45 control patients over one yr. The overall prevalence of vitamin D insufficiency and deficiency was common in both populations, at 76% (95% CI: 61, 87%) in the pediatric renal transplant recipients and 91% (95% CI: 80, 98%) in the control group. In the paired renal transplant samples, the mean 25(OH)D level was 52.3 ± 17.9 nmol/L in the winter and 65.6 ± 18.8 nmol/L in the summer (95% CI diff.: 3.9, 22.7), in keeping with a significant seasonal difference. The mean dietary intake of vitamin D in the renal transplant recipients, assessed by three‐day dietary record, was 5.7 μg/day, with a vitamin D intake below the EAR in the majority. We did not find an association between vitamin D intake and 25(OH)D levels in this study, likely due to the low dietary intake of vitamin D within the transplant population, identifying a potential area for intervention and improvement. 相似文献
42.
Candido R Forbes JM Thomas MC Thallas V Dean RG Burns WC Tikellis C Ritchie RH Twigg SM Cooper ME Burrell LM 《Circulation research》2003,92(7):785-792
The formation of advanced glycation end products (AGEs) on extracellular matrix components leads to accelerated increases in collagen cross linking that contributes to myocardial stiffness in diabetes. This study determined the effect of the crosslink breaker, ALT-711 on diabetes-induced cardiac disease. Streptozotocin diabetes was induced in Sprague-Dawley rats for 32 weeks. Treatment with ALT-711 (10 mg/kg) was initiated at week 16. Diabetic hearts were characterized by increased left ventricular (LV) mass and brain natriuretic peptide (BNP) expression, decreased LV collagen solubility, and increased collagen III gene and protein expression. Diabetic hearts had significant increases in AGEs and increased expression of the AGE receptors, RAGE and AGE-R3, in association with increases in gene and protein expression of connective tissue growth factor (CTGF). ALT-711 treatment restored LV collagen solubility and cardiac BNP in association with reduced cardiac AGE levels and abrogated the increase in RAGE, AGE-R3, CTGF, and collagen III expression. The present study suggests that AGEs play a central role in many of the alterations observed in the diabetic heart and that cleavage of preformed AGE crosslinks with ALT-711 leads to attenuation of diabetes-associated cardiac abnormalities in rats. This provides a potential new therapeutic approach for cardiovascular disease in human diabetes. 相似文献
43.
44.
45.
46.
Sahin Serdar Gundogdu Aycan Nalbantoglu Ufuk Kadioglu Pinar Karaca Zuleyha Hacioglu Aysa Urhan Muhammed Emre Unluhizarci Kursad Demir Ahmet Numan Hora Mehmet Durcan Emre Elbüken Gülsah Dokmetas Hatice Sebile Zuhur Sayid Shafi Kelestimur Fahrettin 《Pituitary》2022,25(3):520-530
Pituitary - Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Oral and fecal... 相似文献
47.
48.
49.
50.
Gary Mierau E.J. Wills Josephine Wyatt–Ashmead Edward Hoffenberg Ernest Cutz 《Ultrastructural pathology》2013,37(6):517-521
Microvillous inclusion disease is a rare lethal disorder characterized by intractable, severe, watery diarrhea beginning in early infancy. The underlying defect is thought to be an autosomal recessive genetic abnormality resulting in defective brush-border assembly and differentiation. Normally, this diagnosis is easily established through the electron microscopic demonstration of characteristic microvilli-lined inclusions lying within the apical cytoplasm of surface enterocytes. In a small number of patients appearing to have microvillous inclusion disease it has not proven possible to demonstrate the typical inclusions. The existence of another entity, termed intestinal microvillous dystrophy, has been proposed to account for such occurrences. This assertion was founded in large part upon the observation that the few subjects studied all displayed a slightly atypical clinical presentation. The case now being presented exhibited the morphologic features ascribed to intestinal microvillous dystrophy but had a clinical presentation that was entirely typical of microvillous inclusion disease. It serves thus to conceptually unite intestinal microvillous dystrophy with microvillous inclusion disease. 相似文献