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Jiuhui Jiang Jiuxiang Lin Changrong Ji 《American journal of orthodontics and dentofacial orthopedics》2005,128(4):520-527
A patient with skeletal Class III malocclusion was treated in 2 phases during the early permanent dentition. In phase 1, maxillary protraction was combined with rapid palatal expansion; in phase 2, fixed appliances were placed. The results were good posttreatment, and, 1 year later, a favorable growth tendency could be observed. This report shows that treatment for a patient with skeletal Class III malocclusion can be started in the early permanent dentition, with very good final results. 相似文献
23.
Lei Wang Moyi Sun Yuegui Jiang Lianjia Yang Delin Lei Chao Lu Yinghua Zhao Pu Zhang Yaowu Yang Jianhu Li 《Journal of oral and maxillofacial surgery》2006,64(4):636-641
PURPOSE: Perineural invasion is a frequent occurrence in salivary adenoid cystic carcinoma (ACC) and may prevent complete surgical resection. Studies have indicated that nerve growth factor (NGF) and its high-affinity receptor tyrosine kinase A (TrkA) may play a role in perineural invasion in several malignancies in which perineural invasion is observed. The present study was conducted to investigate the expression of NGF and TrkA in salivary ACC and to examine the effects of NGF on adhesion, migration and invasion capacities of a salivary ACC cell line (SACC-83) in vitro. PATIENTS AND METHODS: Expression of NGF and TrkA was explored using immunohistochemistry in paraffin-embedded tissues of 32 cases of salivary ACC. The effects of NGF on in vitro adhesion, migration, and invasion capacities of the SACC-83 cell line were examined using an MTT assay and a modified Boyden chamber assay respectively. RESULTS: In ACC specimens, 31 (96.9%) and 32 (100%) tumors showed immunoreactivity for NGF and TrkA respectively. Significant correlations were found between NGF/TrkA expression levels and perineural invasion (P < .05). In cell adhesion assay, the percent adherences of SACC-83 cells co-cultured with 25 ng/ml NGF at 1.5 hours and 5, 25 ng/ml NGF at 6 hours were significantly higher than that co-cultured with 0 ng/ml NGF (P < .05). However, high concentration of NGF (500 ng/ml) resulted in a significant inhibition of invasion (P < .05). CONCLUSION: Overexpression of NGF and TrkA in human salivary ACC tissues may constitute a reason for perineural invasion in salivary ACC. 相似文献
24.
我们用麻醉的正常血压大鼠,大鼠的自体灌液后肢分别研究了美哌隆的降压作用强度、部位、维持时间和对心率的影响。实验结果提示:美哌隆降低动脉血压的作用除依赖于它对外周α_1受体的选择性阻滞外,还依赖于它对外周阻力血管的直接扩张作用。美哌隆在降压的同时也减慢心率,其降压作用和负性频率作用与剂量有关。 相似文献
25.
组织扩张术皮肤胶原的代谢改变 总被引:4,自引:0,他引:4
目的:研究常规扩张(ITE)和持续快速扩张(CTE)对皮肤胶原代谢的影响。方法用白色小家猪制作组织扩张术动物模型,用Gordeladze法测定血清和扩张组织的羟脯氨酸(HP)含量,藻酸盐印模材膜片法测量标记区面积;光镜测量真皮厚度。结果:ITE组血清HP含量升高,0.8倍,CTE组升高1.2倍,ITE和CTE组皮肤含量与正常皮肤相同,组织中HP总量均明显升高,持续扩张皮瓣组(CTEF)术后4wk皮 相似文献
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红细胞不同温度长期冻存后形态和免疫功能的变化及其临床意义 总被引:1,自引:0,他引:1
目的 探讨一种简便、有效的红细胞长期保存的方法。方法 红细胞在-40℃、80℃及-196℃(液氮)不同温度下长期保存18个月后,分别测定冻存前后红细胞平均体积(MCV)、红细胞渗透脆性(RFT)及红细胞免疫功能(RBC-C3bRR、ERPN)。结果 红细胞-40℃长期冻存后,MCV和RFT较冻存前显著提高(P<0.05),RBC-C3bRRt ERPN较冻存前显著降低(P<0.05)。红细胞-80℃、-196℃长期冻存后,MCV、RFT、RBC-C3bRR及ERPN较冻存前无明显改变(P>0.05)。结论 红细胞经-80℃、-196℃长期冻存后,其形态、结构和免疫功能保存良好。-80℃低温冻存是一种简便、有效的红细胞长期保存的方法。 相似文献
28.
Objective. To study the characteristics of changes of LDH enzyme patterns of mice under slight hypoxia.Methods. Mice treated with artificial hypoxia, various tissues were made for the test of LDH enzymatic activity by the specific staining technique. LDH (1 -5) relative percentage enzymatic activity (RPEA) were measured with CS-910 dual-wavelength thin layer chromatography scanner.Results. The RPEA of LDH isozymes of various tissues after slight hypoxia shifted to the isozymes LDH1 and LDH2, whose principal subunits are H subunits, and the RPEA of LDH,(H4), LDH2(H3M) increased, while RPEA of LDH5(M4) in various tissues decreased prominently except the cardiac muscle, and that of LDH4(HM3) decreased as well. After polyacrylamide gel electrophoresis (PAGE) of the hypoxia treated cardiac muscle specimen was made, activity subbands originated regularly in the isozyme patterns of LDH, with the regularity of LDH1 (0 subband), LDH2 (0-1 subbands), LDH3 (0-2 subbands), LDH4 (1-3 subbands), LDH5 (2-4 subbands). 相似文献
29.
高职高专院校生物化学教学体会 总被引:1,自引:0,他引:1
生物化学这门课程理论性强,内容复杂、抽象、难学难记,教学过程中如果采用灵活多样的教学手段,注意调动学生学习的主动性和积极性,即可克服学生的畏难情绪,从而提高学习效率。 相似文献
30.
Objective To study the protective effects of adenovirus-mediated human beta-nerve growth factor gene (hNGFβ) transfer combined with iron fortified nutrition on blast hearing damage in guinea pigs. Methods Deafness was induced by blast (172dB SPL) in 35 healthy guinea pigs. Seven days after noise exposure, 10 guinea pigs were inoculated with adenovirus-mediated hNGFβ (Ad-hNGFβ) into the perilymphatic space (the gene group), another 10 guinea pigs were given hNGFβ combined with iron fortified nutritional diet (the combination group), still another 10 guinea pigs were inoculated with artificial perilymphatic fluid (APF), and 5 guinea pigs served as control, given neither medicine nor noise exposure. Auditory brainstem response (ABR) threshold shifts were monitored in the guinea pigs before blast exposure and after gene transfer. Changes in cochlear morphology were examined with immunohistochemical and HE staining. Results One week after successful inoculation of hNGFβ, it was noted that Ad-hNGFβ protein was expressed in each turn of the cochlea, and its intensity was almost equal. After gene transfer in the combination group and the gene group, ABR threshold shifts at week 1 and 4 were significantly smaller than those of the APF group. HE staining showed that the number of the spiral ganglion cells in the combination group and the Ad-hNGFβ group was significantly higher than that of the control group after 4 weeks (P<0.01). Conclusions Ad-hNGFβ combined with iron fortified nutritional diet was effective in the prevention and treatment of blast hearing damage of cochlear hair cells. 相似文献