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991.
You Chul Kim In Hyuk Chung Woo Kyung Yoo Jin-Suck Suh Sung Jae Kim Chang Il Park 《Clinical anatomy (New York, N.Y.)》1997,10(6):397-404
The purpose of the present study was to provide detailed information of the morphological and radiological characteristics of the posterolateral structures of the knee. Muscles and ligaments of the posterolateral part of the knee were studied by dissections of 50 adult cadaver knees and by Magnetic Resonance Imaging (MRI) before and after dissections for comparisons. Diverse morphological characteristics of the arcuate ligament were found. The fabellofibular ligament was present in 42.1% of the knees dissected, whereas the popliteofibular ligament was found in 37.5%. A ligamentous structure, which could be called the posterior tibial ligament, was found in 31.6% of the cases that originated from the lateral part of the capsule proximally and inserted distally on the mid portion of the proximal tibia. By comparing the cross sections and the dissections of the cadaver knees, the popliteus muscle, the arcuate ligament, the fibular collateral ligament, the popliteofibular ligament, and the fabellofibular ligament could be identified in MRI. Comprehensive understanding of the posterolateral anatomy of the knee and improved identification of the structures in MRI will help clinicians to make a more accurate and noninvasive diagnosis of posterolateral instability. Clin. Anat. 10:397–404, 1997. © 1997 Wiley-Liss, Inc. 相似文献
992.
Won Gun Choi Wonsuk Choi Tae Jung Oh Hye-Na Cha Inseon Hwang Yun Kyung Lee Seung Yeon Lee Hyemi Shin Ajin Lim Dongryeol Ryu Jae Myoung Suh So-Young Park Sung Hee Choi Hail Kim 《The Journal of clinical investigation》2021,131(23)
Insulin resistance is a cornerstone of obesity-related complications such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. A high rate of lipolysis is known to be associated with insulin resistance, and inhibiting adipose tissue lipolysis improves obesity-related insulin resistance. Here, we demonstrate that inhibition of serotonin (5-hydroxytryptamine [5-HT]) signaling through serotonin receptor 2B (HTR2B) in adipose tissues ameliorates insulin resistance by reducing lipolysis in visceral adipocytes. Chronic high-fat diet (HFD) feeding increased Htr2b expression in epididymal white adipose tissue, resulting in increased HTR2B signaling in visceral white adipose tissue. Moreover, HTR2B expression in white adipose tissue was increased in obese humans and positively correlated with metabolic parameters. We further found that adipocyte-specific Htr2b-knockout mice are resistant to HFD-induced insulin resistance, visceral adipose tissue inflammation, and hepatic steatosis. Enhanced 5-HT signaling through HTR2B directly activated lipolysis through phosphorylation of hormone-sensitive lipase in visceral adipocytes. Moreover, treatment with a selective HTR2B antagonist attenuated HFD-induced insulin resistance, visceral adipose tissue inflammation, and hepatic steatosis. Thus, adipose HTR2B signaling could be a potential therapeutic target for treatment of obesity-related insulin resistance. 相似文献
993.
Ji-Yeon Kim Eunjin Lee Kyunghee Park Hae Hyun Jung Woong-Yang Park Kyung-Hun Lee Joohyuk Sohn Keun Seok Lee Kyung Hae Jung Jee Hyun Kim Ki Hyeong Lee Seock-Ah Im Yeon Hee Park 《International journal of cancer. Journal international du cancer》2019,145(6):1669-1678
We aimed to investigate the impact of genetic alterations on the efficacy of poziotinib in a phase II clinical trial of patients with heavily treated HER2-positive metastatic breast cancer (BC). We performed targeted ultra-deep sequencing with a customized cancer gene panel and RNA expression assay using BC specimens. Of 106 patients, biomarker data were available for 85. Copy number (CN) amplifications of HER2 were observed in 72 patients (85%), and CN >8 in 50 (59%). Single nucleotide variants (SNVs) of HER2 were found in 16 patients (19%). Genetic alterations of PIK3CA pathway were found in 40 patients (47%). Median progression free survival (PFS) of the biomarker analysis group was 3.61 months. In terms of PFS, HER2 with CN >8 prolonged (hazard ratio (HR) 0.61, 95% CI: 0.38, 0.97, p = 0.037) and alteration of PIK3CA pathway shortened the duration of survival (HR 2.25, 95% CI: 1.39, 3.63, p = 0.001). SNVs of HER2 increased survival duration, but the effect was not significant (HR: 0.58, 95% CI: 0.31, 1.08, p = 0.085). In addition, SNVs in the ERBB3 cytoplasmic domain decreased poziotinib response (HR: 4.58, 95% CI: 2.02, 10.37, p < 0.001). In multigene analysis, BC with HER2 CN >8 and intact PIK3CA pathway had significantly longer PFS compared to others (HR: 0.37, 95% CI: 0.21, 0.66, p = 0.001), while SNVs in the ERBB3 cytoplasmic domain predicted poor prognosis (HR: 4.28, 95% CI: 1.71, 10.71, p < 0.001). In conclusion, HER2 CN amplification, PIK3CA pathway alteration, and ERBB3 cytoplasmic mutation showed predictive roles on clinical outcomes of HER2-positive MBC treated with poziotinib. 相似文献
994.
Farshad Forouzandeh Jon Suh Eric Stahl Yi-An Ko Suegene Lee Udit Joshi Nitin Sabharwal Zakaria Almuwaqqat Rounak Gandhi Hee Su Lee Sung Gyun Ahn Bill D. Gogas John S. Douglas Gregory Robertson Wissam Jaber Dimitri Karmpaliotis Emmanouil S. Brilakis William J. Nicholson Habib Samady 《The American journal of cardiology》2018,121(1):14-20
995.
Dayong Lee Seul Ki Kim Kidong Kim Jung Ryeol Lee Chang Suk Suh Seok Hyun Kim 《Journal of minimally invasive gynecology》2018,25(1):124-132
Study Objective
To compare operative outcomes of single-port laparoscopic myomectomy (SP-LM) vs conventional laparoscopic myomectomy (CLM), including subjective and objective cosmetic aspects.Design
Prospective randomized controlled trial (Canadian Task Force classification I).Setting
University hospital.Patients
Women with uterine myoma scheduled for laparoscopic myomectomy.Interventions
Sixty-six women were assigned at random to either the SP-LM or CLM group. Surgical outcomes, including patient and observer scar assessments, were evaluated between the groups according to the intention-to-treat principle.Measurements and Main Results
There were no significant differences in demographic characteristics and properties of myomectomy between the groups. There also were no differences in surgical outcomes, such as operation time, estimated blood loss, and complications, between the 2 groups. The mean total score of the Observer Scar Assessment Scale was lower in the SP-LM group at 1 week (13.0?±?3.2 vs 18.3?±?4.8; p?<?.001) and 8 weeks (9.9?±?3.2 vs 14.3?±?3.8; p?<?.001) after discharge. Similar results were obtained for the Patient Scar Assessment Scale at 1 week (11.6?±?7.2 vs 18.5?±?12.8; p?=?.024) and 8 weeks (9.5?±?6.0 vs 18.8?±?9.1; p?<?.001) after discharge. Postoperative pain and analgesic consumption did not differ between the groups, except in patient-controlled analgesia consumption at 6 hours after operation, which was lower in the SP-LM group (12.7?±?6.3?mL vs 16.4?±?6.2?mL; p?=?.039). Operative outcomes were similar in the 2 groups.Conclusion
SP-LM is associated with more favorable cosmetic outcomes and better patient satisfaction compared with CLM. There were no differences in operative outcomes and complications between the 2 modalities. 相似文献996.
997.
J.-S. Kim J.-K. Cha H.W. Nah M.-J. Kang D.-H. Kim H.-S. Park J.-H. Choi H.-K. Suh 《Journal of stroke and cerebrovascular diseases》2018,27(11):3266-3271
Recent studies demonstrated that modified thrombolysis in cerebral infarction (TICI) 3 reperfusion have better functional outcomes than modified TICI 2b after mechanical thrombectomy in acute ischemic stroke with large vessel occlusion. The purpose of this study was to determine significant factors to forecast the presence of complete reperfusion after mechanical thrombectomy based on multimodal magnetic resonance imaging (MRI). We investigated 96 consecutive patients with acute large intracranial artery occlusion of anterior circulation who based on multimodal MRI. Also, we compared clinical and radiologic parameters between patients with modified TICI 3 and those with modified TICI 0-2b. Among 96 eligible subjects received mechanical thrombectomy, 39 patients (40.6%) showed complete reperfusion and 57 partial or nonreperfusion (mTICI 2b-26, mTICI 2a-9, mTICI 1-8, and mTICI 0-14) after mechanical thrombectomy. Patients with mTICI 3 had significantly smaller initial Diffusion weighted images (DWI) lesion volume (P < .01) and much shorter time interval from onset to reperfusion (P < .01) than those patients with mTICI (0-2b). In multivariate analysis, smaller initial DWI volume (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.23-2.57; P < .01) and faster reperfusion time (OR, 1.07; 95% CI 1.01-1.14; P = .015) had an independence significance for complete reperfusion after mechanical thrombectomy. In this study, the ischemic lesion volume on DWI and faster processing time are critical factor to predict the state of complete reperfusion after mechanical thrombectomy. 相似文献
998.
Chang Ki Jang E-Wook Jang Kwang-Chun Cho Sang Hyun Suh Joonho Chung Yong Bae Kim Chang-Ki Hong Jin-Yang Joo 《Neurological sciences》2018,39(10):1735-1740
Background
Proximal A1 segment aneurysms of the anterior cerebral artery (ACA) radiologically resemble internal carotid artery bifurcation (ICBIF) aneurysms because of their anatomical proximity. However, proximal A1 aneurysms exhibit distinguishing features, relative to ICBIF aneurysms. We report our experience of managing proximal A1 aneurysms, then compare them to ICBIF aneurysms.Methods
Among 2191 aneurysms treated between 2000 and 2016 in a single institution, we retrospectively reviewed 100 cases categorized as ICBIF or A1 aneurysms. We included aneurysms originating from the ICBIF and ACA, proximal to the anterior communicating artery (A1 segment) and divided them into two groups: proximal A1 (n?=?32) and ICBIF (n?=?50). If any portion of the aneurysm involved the ICBIF, it was classified as ICBIF. Aneurysms wholly located in the A1 segment were classified as proximal A1. Patient factors and angiographic factors were evaluated and compared.Results
The proximal A1 group exhibited differences in aneurysm size (p?=?0.013), posterior aneurysm direction (p?=?0.001), and A1 perforators as incorporating vessels (p?=?0.001). The proximal A1 group tended to rupture more frequently when the aneurysm was smaller (p?=?0.046). One case of morbidity occurred in the proximal A1 group.Conclusion
Compared to ICBIF aneurysms, proximal A1 aneurysms were smaller and directed posteriorly, with incorporating perforators. Because of these characteristics, it may be difficult to perform clipping with 360° view in microsurgical field. Therefore, when planning to treat proximal A1 aneurysms, different treatment strategies may be necessary, relative to those used for ICBIF aneurysms.999.
1000.
Factors associated with quality of life and functional disability among rheumatoid arthritis patients treated with disease‐modifying anti‐rheumatic drugs for at least 6 months
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Sang‐Cheol Bae Soo‐Kyung Cho Soyoung Won Hye‐Soon Lee Sang‐Heon Lee Young Mo Kang Sang‐Hoon Lee Yeon‐Ah Lee Jung‐Yoon Choe Won‐Tae Chung Chang‐Hee Suh Seung‐Cheol Shim Jisoo Lee Bo Young Yoon Dong‐Wook Kim Shin‐Seok Lee Wan‐Hee Yoo Jin‐Seok Kim Young‐Ok Jung Seong‐Su Nah Choong‐Ki Lee Gwan‐Gyu Song Sung Jae Choi Chung‐Il Joung Hyein Koh Young‐Joo Kim 《International journal of rheumatic diseases》2018,21(5):1001-1009