全文获取类型
收费全文 | 8117篇 |
免费 | 591篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 279篇 |
妇产科学 | 263篇 |
基础医学 | 1009篇 |
口腔科学 | 127篇 |
临床医学 | 1138篇 |
内科学 | 1408篇 |
皮肤病学 | 127篇 |
神经病学 | 737篇 |
特种医学 | 190篇 |
外科学 | 812篇 |
综合类 | 61篇 |
一般理论 | 16篇 |
预防医学 | 1104篇 |
眼科学 | 114篇 |
药学 | 602篇 |
中国医学 | 13篇 |
肿瘤学 | 667篇 |
出版年
2024年 | 23篇 |
2023年 | 113篇 |
2022年 | 124篇 |
2021年 | 230篇 |
2020年 | 198篇 |
2019年 | 244篇 |
2018年 | 257篇 |
2017年 | 211篇 |
2016年 | 258篇 |
2015年 | 253篇 |
2014年 | 309篇 |
2013年 | 462篇 |
2012年 | 660篇 |
2011年 | 732篇 |
2010年 | 361篇 |
2009年 | 295篇 |
2008年 | 550篇 |
2007年 | 536篇 |
2006年 | 535篇 |
2005年 | 491篇 |
2004年 | 368篇 |
2003年 | 404篇 |
2002年 | 355篇 |
2001年 | 69篇 |
2000年 | 41篇 |
1999年 | 60篇 |
1998年 | 64篇 |
1997年 | 45篇 |
1996年 | 46篇 |
1995年 | 35篇 |
1994年 | 41篇 |
1993年 | 31篇 |
1992年 | 36篇 |
1991年 | 16篇 |
1990年 | 29篇 |
1989年 | 20篇 |
1988年 | 15篇 |
1987年 | 14篇 |
1986年 | 18篇 |
1984年 | 9篇 |
1983年 | 16篇 |
1982年 | 14篇 |
1981年 | 13篇 |
1980年 | 9篇 |
1979年 | 15篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1975年 | 8篇 |
1974年 | 15篇 |
1973年 | 8篇 |
排序方式: 共有8729条查询结果,搜索用时 15 毫秒
41.
X. Artières J. Y. Jenny G. Jenny 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》1993,3(2):131-135
Résumé L'étude porte sur une série de 50 prothèses totales de genou GSB implantées entre 1981 et 1988 au Centre de Traumatologie et d'Orthopédie de Strasbourg. Cette prothèse entre dans la catégorie des prothèses à charnières cimentées, mais son pivot semi rigide diminue efficacement les contraintes exercées sur le ciment. Les résultats sont conformes à ceux retrouvés dans la littérature concernant les prothèses à charnière. L'accent a été mis plus particulièrement sur les complications spécifiques à ce type d'arthroplastie : infections, fractures, complications rotuliennes. Cependant le caractère semi rigide de la GSB a permis la disparition presque totale des descellements qui compliquaient d'ordinaire les prothèses à charnière. La prothèse GSB nous semble donc supérieure aux autres modèles de prothèse à charnière. 相似文献
42.
We studied the holding power during cut-out tests of 4 different screw fixation devices of the femoral head, correlated to head size and bone density, on 48 paired deep frozen proximal femurs of fresh gross specimens. We found no significant effect of the device on the holding power. There was a significantly higher maximal load at failure in large and dense heads. It seems then unnecessary to advocate more sophisticated but also more expensive devices to fix femoral neck fractures. 相似文献
43.
44.
45.
Shoshanna Sofaer Christine Crofton Elizabeth Goldstein Elizabeth Hoy Jenny Crabb 《Health services research》2005,40(6P2):2018-2036
46.
Rosie Ashbolt Jenny Barralet Robert Bell Dennis Bittisnich Andrew Black Barry Combs Christine Carson Scott Crerar Craig Dalton Joy Gregory Michelle Harlock Gillian Hall Geoff Hogg Martyn Kirk Karin Lalor Tony Merritt Sally Munnoch Jennie Musto Lillian Mwanri Leonie Neville Chris Oxenford Rhonda Owen Jane Raupach Cameron Sault Russell Stafford Barbara Telfer Hassan Vally Kefle Yohannes 《Communicable diseases intelligence》2005,29(1):85-88
47.
Ines Lessa Maria Jenny Araújo Lucélia Magalh?es Naomar de Almeida Filho Estela Aquino Maria Cecília R Costa 《Pan American journal of public health》2004,16(2):131-137
OBJECTIVE: To estimate the frequency of modifiable cardiovascular risk factors, with and without inclusion of arterial hypertension, occurring simultaneously in a racially-mixed population. METHOD: A cross-sectional study was carried out with 1,298 adults aged > or = 20 years in the city of Salvador, Brazil, in 2000. Eight modifiable cardiovascular risk factors were assessed, in any combination: total cholesterol > or = 240 mg/dL; high density-lipoprotein cholesterol (HDL-c) < 40 mg/dL; triglycerides > or = 200 mg/dL; glycemia > or = 126 mg/dL + well-controlled diabetes; body mass index > or = 25 kg/m2, waist > or = 102 cm for males and > or = 88 cm for females, smoking and alcoholism. The results were stratified according to the number of simultaneous risk factors (zero to five or more and two or more risk factors). The data were analyzed in terms of estimated proportions and 95% confidence intervals (95%CI), with and without the inclusion of arterial hypertension (VI Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [JNC-VI], United States of America), ratio of proportions and chi-square for proportions as a measure of association. RESULTS: Among men (41.4% of participants), 7.5% (95%CI: 2.5 to 9.7) did not present risk factors; 68.8% (95%CI: 65.0 to 72.8) presented two or more risk factors, not including hypertension. After inclusion of hypertension, 73.4% (95%CI: 69.7 to 77.1) presented two or more risk factors. Among women, 11.6% did not present risk factors. The presence of two or more risk factors, not including hypertension, was observed in 67.7% (95%CI: 64.8 to 71.4). After inclusion of hypertension, 71.7% (95%CI: 68.5 to 74.9) of the women presented two or more risk factors. Significant differences were observed for the presence of two or more risk factors in men with not more than 4 years of schooling vs. 5 to less than 11 years of schooling (P < 0.05); in women with not more than 4 years of schooling vs. 5 to less than 11 years of schooling; in women with not more than 4 years of schooling vs. 11 or more years of schooling (P < 0.01); and in black vs. white women (P < 0.01). CONCLUSIONS: The high proportion of clustering cardiovascular risk factors in Salvador, with or without hypertension, especially in the population with little schooling and in black individuals, suggests the need for broad social strategies to reduce social inequality, promote health, and facilitate the treatment of cardiovascular risk factors. 相似文献
48.
Caroline C Dong Xuejun J Yin Jane Y C Ma Lyndell Millecchia Mark W Barger Jenny R Roberts Xing-Dong Zhang James M Antonini Joseph K H Ma 《Toxicological sciences》2005,88(1):150-160
Exposure to diesel exhaust particles (DEP) during the sensitization process has been shown to increase antigen-specific IgE production and aggravate allergic airway inflammation in human and animal models. In this study, we evaluated the effect of short-term DEP exposure on ovalbumin (OVA)-mediated responses using a post-sensitization model. Brown Norway rats were first exposed to filtered air or DEP (20.6 +/- 2.7 mg/m3) for 4 h/day for five consecutive days. One day after the final air or DEP exposure (day 1), rats were sensitized with aerosolized OVA (40.5 +/- 6.3 mg/m3), and then again on days 8 and 15, challenged with OVA on day 29, and sacrificed on days 9 or 30, 24 h after the second OVA exposure or the final OVA challenge, respectively. Control animals received aerosolized saline instead of OVA. DEP were shown to elicit an adjuvant effect on the production of antigen-specific IgE and IgG on day 30. At both time points, no significant airway inflammatory responses and lung injury were found for DEP exposure alone. However, the OVA-induced inflammatory cell infiltration, acellular lactate dehydrogenase activity and albumin content in bronchoalveolar lavage (BAL) fluid, and numbers of T cells and their CD4+ and CD8+ subsets in lung-draining lymph nodes were markedly reduced by DEP on day 30 compared with the air-plus-OVA exposure group. The OVA-induced nitric oxide (NO) in the BAL fluid and production of NO, interleukin (IL)-10, and IL-12 by alveolar macrophages (AM) were also significantly lowered by DEP on day 30 as well as day 9. DEP or OVA alone decreased intracellular glutathione (GSH) in AM and lymphocytes on days 9 and 30. The combined DEP and OVA exposure resulted in further depletion of GSH in both cell types. These results show that short-term DEP exposure prior to sensitization had a delayed effect on enhancement of the sensitization in terms of allergen-specific IgE and IgG production, but caused an attenuation of the allergen-induced airway inflammatory responses. 相似文献
49.
50.
Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients. 总被引:8,自引:0,他引:8
Jenny C Chang Eric C Wooten Anna Tsimelzon Susan G Hilsenbeck M Carolina Gutierrez Yee-Lu Tham Mamta Kalidas Richard Elledge Syed Mohsin C Kent Osborne Gary C Chamness D Craig Allred Michael T Lewis Helen Wong Peter O'Connell 《Journal of clinical oncology》2005,23(6):1169-1177
PURPOSE: Chemotherapy for operable breast cancer decreases the risk of death. Docetaxel is one of the most active agents in breast cancer, but resistance or incomplete response is frequent. PATIENTS AND METHODS: Core biopsies from 24 patients were obtained before treatment with neoadjuvant docetaxel (four cycles, 100 mg/m(2) every 3 weeks), and response was assessed after chemotherapy. After 3 months of neoadjuvant chemotherapy, surgical specimens (n = 13) were obtained, and laser capture microdissection (LCM; n = 8) was performed to enrich for tumor cells. From each core, surgical, and LCM specimen, sufficient total RNA (3 to 6 microg) was extracted for cDNA array analysis using the Affymetrix HgU95-Av2 GeneChip (Affymetrix, Santa Clara, CA). RESULTS: From the initial core biopsies, differential patterns of expression of 92 genes correlated with docetaxel response (P = .001). However, the molecular patterns of the residual cancers after 3 months of docetaxel treatment were strikingly similar, independent of initial sensitivity or resistance. This relative genetic homogeneity after treatment was observed in both LCM and non-LCM surgical specimens. The residual tumor after treatment in tumors that were initially sensitive indicates selection of a residual and resistant subpopulation of cells. The gene expression pattern was populated by genes involved in cell cycle arrest at G(2)M (eg, mitotic cyclins and cdc2) and survival pathways involving the mammalian target of rapamycin. CONCLUSION: A specific and consistent gene expression pattern was found in residual tumors after docetaxel treatment. These profiles provide therapeutic targets that could lead to improved treatment. 相似文献