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972.
Luke J. Peppone Mary E. Reid Kirsten B. Moysich Gary R. Morrow Pascal Jean-Pierre Supriya G. Mohile Tom V. Darling Andrew Hyland 《Cancer causes & control : CCC》2010,21(8):1247-1255
Background
Studies published prior to 1980 failed to find an association between smoking and colorectal cancer, while subsequent studies reported an association after accounting for a three to four decade initiation period. The aims of this study were to determine the effect of accounting for secondhand smoke (SHS) exposure on the association between smoking and colorectal cancer and to determine the association between SHS and colorectal cancer. 相似文献973.
Background
The anticipated extent of antiviral use during an influenza pandemic can have adverse consequences for the development of drug resistance and rationing of limited stockpiles. The strategic use of drugs is therefore a major public health concern in planning for effective pandemic responses. 相似文献974.
976.
Jean Jacques Lefrere Anne-Marie Courouce Robert Girot Yves Bertrand† Jean-Pierre Soulier 《British journal of haematology》1986,62(4):653-658
Recent research has shown that the human parvovirus is a causative agent of aplastic crisis in hereditary haemolytic anaemias. We report six cases--four children and two adults--of hereditary spherocytosis revealed by aplastic crisis due to human parvovirus infection. 相似文献
977.
Jean-Pierre Monthard Bernard Boinon Belabbas Benayad Jamal Brigui Marcel Camps 《Macromolecular chemistry and physics.》1990,191(3):505-516
Four enol esters with a styrene skeleton ( 3a – d ) were synthesized in two steps from commercial products and polymerized or copolymerized with styrene as a comonomer. The polymers and copolymers ( 7 and 8 ) were characterized. They are stable up to 140°C and lose acetic acid upon heating. Chemical modifications, such as nucleophilic substitutions with cyanide ions or nucleophilic addition of butyllithium, were studied. 相似文献
978.
979.
V Westeel S Julien C De Champs J C Polio F Mauny R Gibey J J Laplante J M Aiache A Depierre J C Dalphin 《The European respiratory journal》2000,16(5):886-892
An impairment of respiratory function has been demonstrated in dairy farmers. The objective of this study was to evaluate the relationship of allergy to respiratory function in dairy farmers in a longitudinal study conducted in the Doubs (France). A cohort of male dairy farmers constituted in 1990 was re-evalued in 1995. Subjects completed a medical and occupational questionnaire, and a spirometry test in both 1990 and 1995, in 1995 they were also subjected to immunological tests. Relationships between immunological variables and respiratory function were studied by a multiple linear regression model adjusted for age, smoking status, respiratory symptoms, altitude and occupational exposure. Amongst the 394 subjects of the initial cohort, 330 were included in the longitudinal study and 320 had immunological tests. Log immunoglobulin (Ig) E was negatively correlated with the 1995 respiratory function parameters (p<0.05 for forced expiratory volume in one second (FEV1) and FEV1/vital capacity (VC). Immunoglobulin (Ig) G response to Aspergillus fumigatus detected by enzyme-linked immunosorbent assay (ELISA) was negatively correlated to 1995 respiratory function parameters (VC: p<0.01; FEV1: p<0.001; FEV1/VC: p<0.01). There was a positive relationship between IgG antibodies against Aspergillus fumigatus and the mean annual decline in FEV1 (p<0.01) and FEV1/VC (p<0.01). To conclude, allergy may play a role in the impairment of respiratory function in dairy farmers of the Doubs and sensitization to Aspergillus fumigatus seems to constitute an independent risk factor for the development of airflow obstruction in this occupational setting. 相似文献
980.
René Martin Chantal Frigon Angelo Chrétien Jean-Pierre Tétrault 《Journal canadien d'anesthésie》2000,47(1):43-46
PURPOSE: To compare isobaric with hyperbaric 9.75 mg bupivacaine injected intrathecally, and to evaluate the effects of subsequent injection of lidocaine 2% into the epidural space. METHODS: Patients in group 1 (n = 30) received isobaric 9.75 mg bupivacaine and in group 2 (n = 30) hyperbaric 9.75 mg bupivacaine injected into the subarachnoid space in a combined spinal-epidural technique. They were undergoing urological, gynecological, orthopedic, gastro-intestinal or vascular surgery. Using a double blind technique, the followings parameters were measured: cutaneous analgesia to pinprick, motor blockade, time for two segment regression, time for complete regression of the motor block, quality of anesthesia. In 12 patients the effect of epidural injections of 3 ml lidocaine 2% was observed. RESULTS: Motor and sensory block developed more rapidly (five minutes) in the isobaric group (P<0.05). Maximum upper level (T7+/-2), two-segment regression (52 min in both groups), motor recovery (160 vs. 157 min), and quality of anesthesia did not differ between the two groups. Thirty nine epidural injections of 3 ml lidocaine 2% were given in 12 patients 10 min after spinal injection, 28 were in the hyperbaric group (P<0.05). Twenty six of the epidural injections produced an increase in sensory block of 0 or 1 dermatome, and 13, of 2 or more. CONCLUSION: The block developed more rapidly in the isobaric group, but both isobaric and hyperbaric 9.75 mg bupivacaine produced adequate upper levels of analgesia for surgery. The effect of epidural injections of 3 ml lidocaine 2% was usually minimal. 相似文献