全文获取类型
收费全文 | 277篇 |
免费 | 12篇 |
专业分类
儿科学 | 9篇 |
妇产科学 | 1篇 |
基础医学 | 30篇 |
口腔科学 | 4篇 |
临床医学 | 72篇 |
内科学 | 89篇 |
皮肤病学 | 2篇 |
神经病学 | 13篇 |
特种医学 | 3篇 |
外科学 | 20篇 |
综合类 | 1篇 |
预防医学 | 5篇 |
眼科学 | 18篇 |
药学 | 17篇 |
肿瘤学 | 5篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 6篇 |
2014年 | 9篇 |
2013年 | 10篇 |
2012年 | 17篇 |
2011年 | 18篇 |
2010年 | 7篇 |
2009年 | 8篇 |
2008年 | 10篇 |
2007年 | 9篇 |
2006年 | 12篇 |
2005年 | 26篇 |
2004年 | 24篇 |
2003年 | 15篇 |
2002年 | 18篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 8篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有289条查询结果,搜索用时 15 毫秒
81.
Combined pars plana phacofragmentation, vitrectomy, and Artisan lens implantation for traumatic subluxated cataracts 总被引:2,自引:0,他引:2
Kodjikian L Beby F Spire M Gambrelle J Hubert I Burillon C Grange JD Garweg JG 《Retina (Philadelphia, Pa.)》2006,26(8):909-916
PURPOSE: To report on the outcome of combined pars plana phacofragmentation, vitrectomy, and Artisan lens implantation in the management of subluxated cataracts. METHODS: This prospective, interventional, nonrandomized case series included nine eyes of seven consecutive adult patients with traumatic lens subluxation. Pre- and postoperative data (complete manifest refraction, best spectacle-corrected visual acuity, slit-lamp examination findings, intraocular pressure, fundus status, numerical density of endothelial cells, corneal thickness, and complications) were collected prospectively for all patients. RESULTS: After a median postoperative follow-up of 12 months (range, 8-18 months), a mean spherical equivalent of -0.50 +/- 0.87 diopter (range, +1 to -1.50 diopter) was achieved. The mean logarithm of the minimum angle of resolution visual acuity improved from 1 (preoperatively) to 0.1 (postoperatively) (P = 0.007, Wilcoxon test). Median endothelial cell losses of 15 +/- 8% (P = 0.008) and 14 +/- 16% (P = 0.011) were registered at follow-ups of 1 month and 12 months, respectively. Postoperative complications included chronic intraocular inflammation and superior corectopia. CONCLUSIONS: Our procedure appears to be a safe, accurate, stable, and efficacious option for the management of traumatic subluxated cataracts in adults. However, longer-term data are needed to evaluate the corneal endothelium. 相似文献
82.
Abraham JD Himoudi N Kien F Berland JL Codran A Bartosch B Baumert T Paranhos-Baccala G Schuster C Inchauspé G Kieny MP 《Vaccine》2004,22(29-30):3917-3928
We have evaluated in C57/Bl6 and HLA-A2.1 transgenic mice the immunogenicity of three MVA vectors expressing either native HCV E1E2 polyprotein, truncated and secreted E1 (E'1(311)) and E2 (E'2(661)) proteins, or a chimeric E1E2 heterodimer presented at the plasma membrane. Immunization induced mainly a Th1 response in HLA-A2.1 transgenic mice while a Th2-type response was detected in C57/Bl6 mice. Comparison of the three vectors shows an increase in the humoral response when antigens are secreted or membrane bound, and slightly in the cellular response when antigens are exposed on the cell surface. 相似文献
83.
Laurent?KodjikianEmail author Justus?G.?Garweg Jacques?Fleury Fran?ois?Rocher Carole?Burillon Jean-Daniel?Grange 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2004,242(6):523-526
Purpose To report an unusual case of almost simultaneous bilateral rhegmatogenous retinal detachment in the context of external-beam radiotherapy for a tumor at a non-ocular target site and in the absence of pre-existing ocular pathology.Methods Observational case report with review of corresponding literature.Results A 63-year-old man was referred for bilateral retinal detachment which was associated with many horseshoe tears and proliferative vitreoretinopathy. He had undergone surgery for a carcinoma of the left maxillary sinus 4 months prior to the presentation and had then received external-beam radiotherapy for 3 months. There was no familial history of retinal detachment and/or eye trauma in this hyperopic patient with clear native lenses. No chorioretinal pathology was apparent that could have predisposed the retinas to tearing.Conclusions Simultaneous bilateral retinal detachment is exceptional, especially in a patient with no risk factors. The effect of radiotherapy on the vitreoretinal interface is discussed in the light of existing data and may have been responsible for our patients retinal detachment.This study received no funding, and the authors had no financial or proprietary interest in itLaurent Kodjikian had full access to all available data and takes full responsibility for their integrity and for the accuracy of the analysisStudy previously presented at the meeting of the French Ophthalmologic Society on 10 May 2003 in Paris, France 相似文献
84.
Prognostic factors of liver metastases from uveal melanoma 总被引:4,自引:0,他引:4
Laurent?KodjikianEmail author Jean-Daniel?Grange Stéphano?Baldo Stéphanie?Baillif Justus?G.?Garweg Michel?Rivoire 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2005,243(10):985-993
Objectives This study was designed to assess survival and identify prognostic factors for liver metastases diagnosed by systematic screening
in uveal melanoma patients.
Methods Among 602 consecutive patients treated over 10 years for uveal melanoma and followed by systematic semi-annual hepatic screening
(abdominal ultrasonography), 63 (10.5%) developed liver metastases; these patients form the basis of this study. Factors including
patient demographics, characteristics of the uveal tumor, metastasis-free interval, severity of liver metastatic involvement,
and treatments of metastases were studied retrospectively regarding their prognostic value, using univariate (Kaplan-Meier
method) and multivariate (Cox model) analyses.
Results Thirty-five patients (55.6% of the metastatic population) received systemic chemotherapy or best supportive care only; 14
patients (22.2% of the metastatic population) diagnosed with diffuse liver involvement had cytoreductive surgery and intra-arterial
chemotherapy; 14 (22.2% of the metastatic population) had complete surgical removal of liver metastases followed by postoperative
intra-arterial chemotherapy. No significant surgical complications were experienced. The median overall survival after diagnosis
of liver metastases was 15 months. It reached 25 months for selected patients with complete resection (P=0.0002). In this cohort of 63 patients, ten or fewer preoperatively diagnosed metastases and primary uveal melanoma not involving
the ciliary body were independently associated with better prognosis.
Conclusions This study suggests that selected patients with screened liver metastases from uveal melanoma may benefit from aggressive
treatment, including surgery. The two independent favorable prognostic factors are fewer than ten metastases at screening
and the absence of ciliary body involvement.
Laurent Kodjikian had full access to all the data and takes responsibility for the integrity of the data in the study and
the accuracy of the data analysis
A summary of this work was presented at the 27th congress of the “Societa Italiana di Chirurgia Oncologica” (May 29–31, 2003)
and published as an abstract
This work was presented at the 24th Meeting of the Club Jules Gonin, September 2004, Athens (Greece) 相似文献
85.
Laurent?KodjikianEmail author Jean-Daniel?Grange Michel?Rivoire 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2005,243(6):622-624
Background To report the protracted 9-year survival of a patient after surgical management of multiple liver metastases from uveal melanoma.Design Interventional case report.Methods A 30-year-old patient, treated for choroidal melanoma by proton beam therapy, was semiannually followed by abdominal ultrasonography. Two years after initial treatment, a total body computed tomography scan suggested the diagnosis of isolated liver metastases.Results Multiple wedge resections and postoperative intra-arterial chemotherapy with fotemustine were performed. After 4 years, a metastatic nodule in the head of the pancreas was detected and surgically removed. Eighteen months later, metastases were progressively detected in other organs. The patient finally died of carcinomatous meningitis 9 years of first treatment of metastases.Conclusions In the present case, the surgical control of liver metastases associated with intra-arterial chemotherapy prolonged the quality and length of life with progressive disease extension to other organs.This study received no funding, and the authors had no financial or proprietary interest in it. Laurent Kodjikian and Michel Rivoire have full access to all available data and take full responsibility for its integrity and for the accuracy of the analysis. The authors agree to allow Graefes Archive for Clinical and Experimental Ophthalmology to review the data if requested. 相似文献
86.
Hecq JD Boitquin LP Vanbeckbergen DF Jamart J Galanti LM 《The Annals of pharmacotherapy》2005,39(10):1654-1658
BACKGROUND: Ketorolac tromethamine is a nonsteroidal agent with potent analgesic and moderate antiinflammatory activity. Advance preparation of intravenous solution could be useful to improve quality assurance, time management, and cost-savings of drug delivery. OBJECTIVE: To investigate the effect of freezing, long-term storage, and microwave thawing on the stability of ketorolac tromethamine in dextrose 5% infusion. METHODS: Five polyolefin bags of solution containing ketorolac tromethamine 20 mg per 100 mL of dextrose 5% were frozen for 3 months at -20 degrees C, thawed in a microwave oven with a validated cycle, and stored at 4 degrees C. The concentration of ketorolac was measured by HPLC. Visual inspection and pH measurement were also carried out. RESULTS: No color change or precipitation was observed. Ketorolac was stable for at least 60 days under refrigeration after freeze-thaw. Throughout this period, the lower confidence limit of the estimated regression line of the concentration-time profile remained >90% of the initial concentration, and the pH value decreased slightly without affecting chromatographic parameters. CONCLUSIONS: Within these limits, ketorolac tromethamine in dextrose 5% infusion may be prepared and frozen in advance by a centralized intravenous admixture service, then thawed before use in clinical units. 相似文献
87.
88.
89.
90.