全文获取类型
收费全文 | 6872篇 |
免费 | 532篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 166篇 |
妇产科学 | 158篇 |
基础医学 | 1157篇 |
口腔科学 | 212篇 |
临床医学 | 672篇 |
内科学 | 1426篇 |
皮肤病学 | 196篇 |
神经病学 | 712篇 |
特种医学 | 332篇 |
外国民族医学 | 2篇 |
外科学 | 666篇 |
综合类 | 84篇 |
一般理论 | 5篇 |
预防医学 | 624篇 |
眼科学 | 45篇 |
药学 | 445篇 |
中国医学 | 17篇 |
肿瘤学 | 460篇 |
出版年
2023年 | 31篇 |
2022年 | 52篇 |
2021年 | 113篇 |
2020年 | 90篇 |
2019年 | 109篇 |
2018年 | 152篇 |
2017年 | 107篇 |
2016年 | 138篇 |
2015年 | 145篇 |
2014年 | 181篇 |
2013年 | 263篇 |
2012年 | 361篇 |
2011年 | 356篇 |
2010年 | 224篇 |
2009年 | 204篇 |
2008年 | 307篇 |
2007年 | 309篇 |
2006年 | 289篇 |
2005年 | 313篇 |
2004年 | 270篇 |
2003年 | 264篇 |
2002年 | 266篇 |
2001年 | 228篇 |
2000年 | 252篇 |
1999年 | 209篇 |
1998年 | 118篇 |
1997年 | 95篇 |
1996年 | 112篇 |
1995年 | 72篇 |
1994年 | 64篇 |
1993年 | 72篇 |
1992年 | 126篇 |
1991年 | 145篇 |
1990年 | 149篇 |
1989年 | 128篇 |
1988年 | 113篇 |
1987年 | 99篇 |
1986年 | 97篇 |
1985年 | 106篇 |
1984年 | 101篇 |
1983年 | 58篇 |
1982年 | 40篇 |
1981年 | 36篇 |
1980年 | 31篇 |
1979年 | 37篇 |
1978年 | 33篇 |
1977年 | 36篇 |
1972年 | 28篇 |
1968年 | 31篇 |
1967年 | 28篇 |
排序方式: 共有7430条查询结果,搜索用时 15 毫秒
991.
Jette Jansen Erik Hansen Niels Hobolth Petrea Jacobsen Margareta Mikkelsen 《Clinical genetics》1976,9(2):163-168
A patient is described who in addition to having the 48, XXXY Klinefelter syndrome has the autosomal dominant nail-patella syndrome, inherited through his mother from the grandfather. Clinical signs of both syndromes were found. Chromosomal investigation with BUDR incorporation and acridine orange staining showed that one X chromosome stained intensively, while the other X chromosomes were elongated and weakly stained. Difference in degree of stretching of the supernumerary chromosomes was noted. The occurrence of the two rare syndromes in the same patient is assumed to be fortuitous. 相似文献
992.
993.
994.
Sixteen patients suffering from hemicranial attacks are reported. After many years of unsuccessful conservative treatment (mean = 12.4 years), the patients were treated surgically with good results. The radiological or electrophysiological examinations were non-specific or negative. Only vasoactive tests (provoking or relieving pain) or local anesthesia proved helpful in diagnosing and localizing the origin of pain. Intraoperatively, hemicranial attacks were found to be caused by vascular irritation or compression of the cervical nerve root C2. After decompression (n = 6) or dissection (n = 10) of the nerve root and the ganglion, 12 patients were relieved of their pain, 2 had improved relatively, 1 showed only a slight improvement, and in 1 patient no cause was found and no improvement was achieved. Two patients suffered recurrence of pain postoperatively; one had no further complaints after root extirpation following percutaneous thermorhizotomy. Electron microscopic examination of the nerve root and its ganglion revealed focal morphological changes, including proliferation of connective tissue in the endoneurium and the ganglion itself, the formation of onion-bulb-like structures around single axons, discrete signs of myelin damage and axonal degeneration. These morphological changes are possibly the result of a chronic vascular compression. 相似文献
995.
996.
997.
Invasive fungal infections (IFI) are frequent causes of mortality after allogeneic stem-cell transplantation (SCT). A very important risk factor for IFI is the use of steroids. We used a risk-based chemoprevention in an open-labelled pilot study. All patients received oral fluconazole or itraconazole (200-400 mg day(-1)) during their neutropenic episode. Starting on day +30, patients receiving prednisone > or =30 mg day(-1) were switched to twice weekly Amphotericin-B-lipid-complex (ABLC) in a dose of 4 mg kg(-1). Patients receiving lower steroid doses continued on the fluconazole/itraconazole prophylaxis. Between 1999 and 2002, 100 patients were enrolled and followed for IFI for 1 year. Seven patients were started on therapeutic daily ABLC treatment before day +30 because of documented or suspected IFI; four had definite or probable aspergillosis, and two had candidaemia. Thirty patients did not need prophylactic ABLC; only one developed candidaemia. Sixty-three patients received ABLC prophylaxis for a median of 52 days (range: 1-289). Seven of these patients developed IFI; one definite and two probable cases of aspergillosis, one case of probable Trichosporon beigelii infection, and three cases of candidaemia. The twice weekly ABLC was well tolerated. This risk-based chemoprevention appears to be effective and might diminish the role of steroids as risk factor for IFI after allogeneic SCT. The relatively high incidence of early IFI suggests that additional prophylaxis for IFI may be indicated for poor-risk patients prior to day +30. 相似文献
998.
999.
Parents often do not recognize overweight in their child, regardless of their socio-demographic background 总被引:1,自引:0,他引:1
To involve parents successfully in the treatment of overweight in their child, they first need to be aware of the problem and its accompanying health risks. Data on 1840 9-11 year olds from the Rotterdam Youth Health Monitor were analysed to investigate whether awareness of parents differs according to socio-demographic characteristics. In the case of overweight children, 50% of the parents do not recognize that their child is overweight. Except for age none of the investigated socio-demographic characteristics, including ethnicity and parental education, was associated with awareness. Parents of obese children show greater awareness than parents of overweight children. 相似文献
1000.
van der Sluijs KF van Elden LJ Xiao Y Arens R Nijhuis M Schuurman R Florquin S Jansen HM Lutter R van der Poll T 《Antiviral research》2006,70(2):75-84
T helper 1-driven immune responses have been implicated in protective immunity against viral infections. Interleukin (IL)-12 is a heterodimeric proinflammatory cytokine formed by a p35 and a p40 subunit that can induce differentiation of na?ve T cells towards a T helper 1-response. To determine the role of IL-12 in respiratory tract infection with influenza, p35 gene deficient (p35-/-) and normal wild type mice were intranasally infected with influenza A virus. IL-12 p35-/- mice displayed a transiently enhanced rather than an impaired viral clearance, as indicated by a 10-fold reduction in viral loads on day 8 after infection. Although interferon-gamma levels were significantly lower in the lungs of IL-12 p35-/- mice, their cellular immune responses were not altered, as reflected by similar T cell CD69 expression and influenza-specific T cell recruitment. Our data indicate that endogenous IL-12 impairs viral clearance during the late phase of influenza A virus infection in mice. 相似文献