全文获取类型
收费全文 | 6890篇 |
免费 | 514篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 166篇 |
妇产科学 | 158篇 |
基础医学 | 1157篇 |
口腔科学 | 212篇 |
临床医学 | 672篇 |
内科学 | 1426篇 |
皮肤病学 | 196篇 |
神经病学 | 712篇 |
特种医学 | 332篇 |
外国民族医学 | 2篇 |
外科学 | 666篇 |
综合类 | 84篇 |
一般理论 | 5篇 |
预防医学 | 624篇 |
眼科学 | 45篇 |
药学 | 445篇 |
中国医学 | 17篇 |
肿瘤学 | 460篇 |
出版年
2023年 | 31篇 |
2022年 | 52篇 |
2021年 | 113篇 |
2020年 | 90篇 |
2019年 | 109篇 |
2018年 | 152篇 |
2017年 | 107篇 |
2016年 | 138篇 |
2015年 | 145篇 |
2014年 | 181篇 |
2013年 | 263篇 |
2012年 | 361篇 |
2011年 | 356篇 |
2010年 | 224篇 |
2009年 | 204篇 |
2008年 | 307篇 |
2007年 | 309篇 |
2006年 | 289篇 |
2005年 | 313篇 |
2004年 | 270篇 |
2003年 | 264篇 |
2002年 | 266篇 |
2001年 | 228篇 |
2000年 | 252篇 |
1999年 | 209篇 |
1998年 | 118篇 |
1997年 | 95篇 |
1996年 | 112篇 |
1995年 | 72篇 |
1994年 | 64篇 |
1993年 | 72篇 |
1992年 | 126篇 |
1991年 | 145篇 |
1990年 | 149篇 |
1989年 | 128篇 |
1988年 | 113篇 |
1987年 | 99篇 |
1986年 | 97篇 |
1985年 | 106篇 |
1984年 | 101篇 |
1983年 | 58篇 |
1982年 | 40篇 |
1981年 | 36篇 |
1980年 | 31篇 |
1979年 | 37篇 |
1978年 | 33篇 |
1977年 | 36篇 |
1972年 | 28篇 |
1968年 | 31篇 |
1967年 | 28篇 |
排序方式: 共有7430条查询结果,搜索用时 0 毫秒
91.
Background
Pulmonary dysfunction following cardiac surgery is believed to be caused, at least in part, by a lung vascular injury and/or atelectasis following cardiopulmonary bypass (CPB) perfusion and collapse of non-ventilated lungs. 相似文献92.
An evaluation of cardiac output by five arterial pulse contour techniques during cardiac surgery 总被引:2,自引:0,他引:2
The bias, precision and tracking ability of five different pulse contour methods were evaluated by simultaneous comparison of cardiac output values from the conventional thermodilution technique (COtd). The five different pulse contour methods included in this study were: Wesseling's method (cZ); the Modelflow method; the LiDCO system; the PiCCO system and a recently developed Hemac method. We studied 24 cardiac surgery patients undergoing uncomplicated coronary artery bypass grafting. In each patient, the first series of COtd was used to calibrate the five pulse contour methods. In all, 199 series of measurements were accepted by all methods and included in the study. COtd ranged from 2.14 to 7.55 l.min(-1), with a mean of 4.81 l.min(-1). Bland-Altman analysis showed the following bias and limits of agreement: cZ, 0.23 and - 0.80 to 1.26 l.min(-1); Modelflow, 0.00 and - 0.74 to 0.74 l.min(-1); LiDCO, - 0.17 and - 1.55 to 1.20 l.min(-1); PiCCO, 0.14 and - 1.60 to 1.89 l.min(-1); and Hemac, 0.06 and - 0.81 to 0.93 l.min(-1). Changes in cardiac output larger than 0.5 l.min(-1) (10%) were correctly followed by the Modelflow and the Hemac method in 96% of cases. In this group of subjects, without congestive heart failure, with normal heart rhythm and reasonable peripheral circulation, the best results in absolute values as well as in tracking changes in cardiac output were measured using the Modelflow and Hemac pulse contour methods, based on non-linear three-element Windkessel models. 相似文献
93.
Jurriën Stiekema MD Anouk K. Trip MD Edwin P. M. Jansen MD PhD Henk Boot MD PhD Annemieke Cats MD PhD Olga Balague Ponz MD PhD Marcel Verheij MD PhD Johanna W. van Sandick MD PhD 《Annals of surgical oncology》2014,21(4):1107-1114
Background
A microscopically irradical (R1) resection is a well-known adverse prognostic factor after gastric cancer surgery. However, the prognostic significance of an R1 resection in gastric cancer patients who are treated with chemoradiotherapy (CRT) after the operation has been poorly studied. Therefore, the aim of this study was to evaluate the effect of an R1 resection on (recurrence-free) survival in gastric cancer patients who were treated with CRT after surgery.Methods
Gastric cancer patients who had undergone a resection with curative intent followed by adjuvant CRT at our institute between 2001 and 2011 were included. CRT consisted of radiotherapy (45 Gy/25 fractions) combined with concurrent capecitabine (with or without cisplatin) or 5-fluorouracil/leucovorin.Results
A consecutive series of 110 patients was studied, including 80 (73 %) patients who had undergone an R0 resection and 30 (27 %) patients with an R1 resection. Pathologic T-classification (p = 0.26), N-classification (p = 0.77), and histologic subtype according to Laurén (p = 0.071) were not significantly different between these groups. Three-year recurrence-free survival (45 vs. 35 %, p = 0.34) and overall survival (47 vs. 48 %, p = 0.58) did not significantly differ between patients who had undergone an R0 or R1 resection. In a multivariate analysis, pathologic T-classification and N-classification were independent prognostic factors for survival.Conclusions
A R1 resection was not an adverse prognostic factor in gastric cancer patients who had undergone CRT after the operation. 相似文献94.
Background
Traumatic brain injury is common. Guidelines from the Brain Trauma Foundation and the Scottish Intercollegiate Guidelines Network recommend that patients with suspected severe traumatic brain injury should be treated in centres with neurosurgical expertise. Scotland does not have a framework for the delivery of trauma care. The aim of this study was to examine the demographic characteristics of incidents involving patients who have suffered a suspected traumatic brain injury, and to evaluate the level of the destination healthcare facility which patients are currently taken to.Methods
Retrospective analysis of prospectively collected Scottish Ambulance Service data on incidents involving traumatic injury, between Nov 2008 and Oct 2010. Two groups of casualties were analysed: those who had a Glasgow coma scale of less than 14 (GCS < 14), and those who had a Glasgow coma scale of less than 9 (GCS < 9).Results
126,934 incidents were identified and analysed. 3890 (3.1%) patients had a GCS of less than 14, and 657 (0.5% of total) had a GCS of less than 9. Almost one-third of incidents involving patients with either a GCS < 14 or GCS < 9 occurred in the greater Glasgow health board area. The Lothian health board region had the second-highest number of patients with either a GCS < 14 or GCS < 9. Only 13.8% of patients with a GCS < 14, and 16.7% of those with a GCS < 9, were taken to a hospital with a neurosurgical service.Conclusions
Many patients who may harbour a traumatic brain injury are taken to a facility which may not be equipped or staffed to deal with such injuries. This mismatch needs to be addressed. However, the care of patients with head injuries is only one aspect of trauma care. The UK has long lagged behind North America in terms of the quality of trauma care provided, although the provision of trauma care in England is currently undergoing major changes. Scotland should consider the development of a similar service delivery framework. 相似文献95.
Screening for early ovarian cancer 总被引:5,自引:0,他引:5
96.
97.
Soenke Percy Frey MD Hendrik Jansen MD Michael J. Raschke MD Rainer H. Meffert MD Sabine Ochman MD 《Clinical orthopaedics and related research》2012,470(12):3607-3614
Background
Complicated tibial fractures with severe soft tissue trauma are challenging to treat. Frequently associated acute compartment syndrome can result in scarring of muscles with impaired function. Several studies have shown a relationship between angiogenesis and more effective muscle regeneration. Vascular endothelial growth factor (VEGF) is associated with angiogenesis but it is not clear whether it would restore muscle force, reduce scarring, and aid in muscle regeneration after acute musculoskeletal trauma.Questions/purposes
Therefore, we asked whether local application of VEGF (1) restores muscle force, (2) reduces scar tissue formation, and (3) regenerates muscle tissue.Methods
We generated acute soft tissue trauma with increased compartment pressure in 22 rabbits and shortened the limbs to simulate fracture débridement. In the test group (n = 11), a VEGF-coated collagen matrix was applied locally around the osteotomy site. After 10 days of limb shortening, gradual distraction of 0.5 mm per 12 hours was performed to restore the original length. Muscle force was measured before trauma and on every fifth day after trauma. Forty days after shortening we euthanized the animals and histologically determined the percentage of connective and muscle tissue.Results
Recovery of preinjury muscle strength was greater in the VEGF group (2.4 N; 73%) when compared with the control (1.8 N; 53%) with less connective and more muscle tissue in the VEGF group. The recovery of force was related to the percentage of connective tissue versus muscle fibers.Conclusions
Local application of VEGF may improve restoration of muscle force by reducing connective tissue and increasing the relative amount of muscle fibers.Clinical Relevance
VEGF may be useful to improve skeletal muscle repair by modulating muscle tissue regeneration and fibrosis reduction after acute trauma. 相似文献98.
M. Witjes A. Kotsopoulos I.H.F. Herold L. Otterspoor K.S. Simons J. van Vliet M. de Blauw B. Festen J.J.A. Eijkenboom N.E. Jansen J.G. van der Hoeven W.F. Abdo 《American journal of transplantation》2017,17(7):1922-1927
Many patients with acute devastating brain injury die outside intensive care units and could go unrecognized as potential organ donors. We conducted a prospective observational study in seven hospitals in the Netherlands to define the number of unrecognized potential organ donors outside intensive care units, and to identify the effect that end‐of‐life care has on organ donor potential. Records of all patients who died between January 2013 and March 2014 were reviewed. Patients were included if they died within 72 h after hospital admission outside the intensive care unit due to devastating brain injury, and fulfilled the criteria for organ donation. Physicians of included patients were interviewed using a standardized questionnaire regarding logistics and medical decisions related to end‐of‐life care. Of the 5170 patients screened, we found 72 additional potential organ donors outside intensive care units. Initiation of end‐of‐life care in acute settings and lack of knowledge and experience in organ donation practices outside intensive care units can result in under‐recognition of potential donors equivalent to 11–34% of the total pool of organ donors. Collaboration with the intensive care unit and adjusting the end‐of‐life path in these patients is required to increase the likelihood of organ donation. 相似文献
99.
M Bhatia B Singh N Nicolaou KJ Ravikumar 《Annals of the Royal College of Surgeons of England》2009,91(5):414-416