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排序方式: 共有358条查询结果,搜索用时 717 毫秒
1.
Diana Lüftner Andreas D. Hartkopf Michael P. Lux Friedrich Overkamp Hans Tesch Adriana Titzmann Patrik Pschke Markus Wallwiener Volkmar Müller Matthias W. Beckmann Erik Belleville Wolfgang Janni Tanja N. Fehm Hans-Christian Kolberg Johannes Ettl Diethelm Wallwiener Andreas Schneeweiss Sara Y. Brucker Peter A. Fasching 《Breast care (Basel, Switzerland)》2021,16(2):108
BackgroundThe therapeutic armamentarium for patients with metastatic breast cancer is becoming more and more specific. Recommendations from clinical trials are not available for all treatment situations and patient subgroups, and it is therefore important to collect real-world data.SummaryTo develop recommendations for up-to-date treatments and participation in clinical trials for patients with metastatic breast cancer, the Prospective Academic Translational Research PRAEGNANT Network was established to optimize the quality of oncological care in the advanced therapeutic setting. The main aim of PRAEGNANT is to systematically record medical care for patients with metastatic breast cancer in the real-life setting, including the outcome and side effects of different treatment strategies, to monitor quality-of-life changes during therapy, to identify patients eligible for participation in clinical studies, and to allow targeted therapies based on the molecular structures of breast carcinomas.Key MessagesThis article describes the PRAEGNANT network and sheds light on the question of whether the various end points from clinical trials can be transferred to the real-world treatment situation. 相似文献
2.
Impact of medical and demographic factors on long-term quality of life and body image of breast cancer patients. 总被引:5,自引:0,他引:5
K H?rtl W Janni R K?stner H Sommer B Strobl B Rack M Stauber 《Annals of oncology》2003,14(7):1064-1071
BACKGROUND: The impact of various medical and demographic factors on the quality of life (QoL) of breast cancer patients has been discussed controversially. We investigated the influence of six different factors on long-term QoL and body image of women with primary breast cancer. PATIENTS AND METHODS: Two-hundred and seventy-four breast cancer patients were administered the QoL questionnaire following a mean interval of 4.2 years after primary diagnosis. All women had been primarily treated for stage I to III breast cancer without evidence of distant metastases. QoL was evaluated by using the QLQ-C30 questionnaire Version 2.0. Supplementary scales included body image, satisfaction with surgical treatment, cosmetic result and fear of recurrence. We analyzed the impact of tumor stage, surgical treatment, adjuvant radiotherapy, adjuvant cytotoxic therapy, age and length of follow-up period on the examined outcome parameters. RESULTS: At the time of the follow-up examination, patients showed minor impairment of QoL (mean 67.8) and body image (mean 24.8), but more fear of recurrence (mean 60.7). None of the studied factors had a significant impact on overall QoL (P >0.05) according to the QLQ-C30 questionnaire. In contrast, with the exception of the factors 'cytotoxic therapy' and 'radiotherapy' all investigated variables influenced at least one of the additional psychological scales (P <0.05). The primary surgical treatment modality had the strongest impact and affected all four scales. Patients treated with breast conservation reported a more favorable body image, compared to those treated with mastectomy (17.2 versus 37.5, P <0.01), more satisfaction with surgical treatment (4.0 versus 10.7, P = 0.01), rated a better cosmetic result (75.5 versus 57.1, P <0.01), but presented more fear of recurrence (63.9 versus 55.3, P = 0.04). CONCLUSION: Current QoL questionnaires do not sufficiently cover all relevant aspects of QoL, but might be complemented by breast cancer specific aspects such as body image and fear. 相似文献
3.
4.
Approximately 42% of all cervical and 7.5% of all endometrial cancer patients are diagnosed at an age when they have potentially not yet realized or completed family planning. In the early stages of these diseases most patients undergoing appropriate therapy can be cured. However, standard therapies are incompatible with the wish to conceive so that there is a need for alternative concepts allowing preservation of fertility. For both tumor entities corresponding treatment plans and operative procedures have been published. Previous studies have shown that preservation of fertility and successfully completed pregnancies can be achieved. A careful selection of suitable patients is mandatory as clinical understaging leads to an oncologically inappropriate therapy and therefore to an avoidable increase in risk of recurrence. 相似文献
5.
6.
Michael Untch Bernd Gerber Nadia Harbeck Christian Jackisch Norbert Marschner Volker M?bus Gunter von Minckwitz Sibylle Loibl Matthias W. Beckmann Jens-Uwe Blohmer Serban-Dan Costa Thomas Decker Ingo Diel Thomas Dimpfl Wolfgang Eiermann Tanja Fehm Klaus Friese Fritz J?nicke Wolfgang Janni Walter Jonat Marion Kiechle Uwe K?hler Hans-Joachim Lück Nicolai Maass Kurt Possinger Achim Rody Anton Scharl Andreas Schneeweiss Christoph Thomssen Diethelm Wallwiener Anja Welt 《Breast care (Basel, Switzerland)》2013,8(3):221-229
Zusammenfassung
Alle zwei Jahre findet in St. Gallen (Schweiz) die internationale Konsensuskonferenz zur Behandlung des primären Mammakarzinoms statt. Da sich das internationale Panel in St. Gallen aus Experten unterschiedlicher Länder zusammensetzt, spiegelt der Konsensus ein internationales Meinungsbild wider. Vor diesem Hintergrund erscheint es aus deutscher Sicht sinnvoll, die Abstimmungsergebnisse für den Therapiealltag in Deutschland zu konkretisieren. Eine deutsche Arbeitsgruppe mit acht Brustkrebsexperten, von denen zwei Mitglieder des internationalen St. Gallen-Panels sind, hat daher die Abstimmungsergebnisse der St. Gallen-Konsensuskonferenz (2013) für den Klinikalltag in Deutschland kommentiert. Inhaltliche Schwerpunkte der diesjährigen St. Gallen-Konferenz waren operative Fragestellungen der Brust und der Axilla, strahlentherapeutische und systemische Therapieoptionen sowie die klinische Relevanz der Tumorbiologie. Intensiv diskutiert wurde der klinische Einsatz von Multigen-Assays, inkl. ihrer Bedeutung für die individuelle Therapieentscheidung. 相似文献7.
8.
Tanja Fehm Monika Hampl Wolfgang Janni Sherko Kümmel Anton Scharl Peter Mallmann Barbara Schmalfeldt Jalid Sehouli 《Der Gyn?kologe》2016,49(9):670-673
The gynecologist as gynecologic oncologist: Comprehensive knowledge about oncologic diseases of the breast and the female genital tract is an essential part of the residency program in Obstetrics and Gynecology. Medical training includes prevention, diagnostics, surgical, medical as well as complementary therapy and follow-up of female cancer. The fellowship in Gynecologic Oncology aims to deepen these basic skills. Knowledge in diagnosis and indications, respectively, for medical and surgical oncologic treatment strategies is expanded. Surgical skills in oncologic procedures including breast and abdominal surgery are acquired. After finishing the fellowship, the gynecologic oncologist should be capable to indicate, plan and perform medical and surgical treatments in cancerous diseases of the breast and the female genital tract. Moreover, it is essential for gynecologic oncologists to understand and include multidisciplinary treatment strategies in cooperation with radiotherapists, general surgeons and medical oncologists to achieve optimal results for their cancer patients 相似文献
9.
Lécuyer H Audibert J Bobigny A Eckert C Jannière-Nartey C Buu-Hoï A Mainardi JL Podglajen I 《Journal of clinical microbiology》2007,45(10):3474-3475
We report a case of non-ventilator-associated nosocomial pneumonia and septicemia due to Dolosigranulum pigrum, a rare gram-positive opportunistic pathogen. The organism was isolated from bronchoalveolar lavage fluid and blood of a debilitated patient. D. pigrum was identified after 16S rRNA gene sequencing. 相似文献