全文获取类型
收费全文 | 1275篇 |
免费 | 65篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 98篇 |
妇产科学 | 16篇 |
基础医学 | 187篇 |
口腔科学 | 3篇 |
临床医学 | 113篇 |
内科学 | 281篇 |
皮肤病学 | 21篇 |
神经病学 | 49篇 |
特种医学 | 34篇 |
外科学 | 95篇 |
综合类 | 75篇 |
预防医学 | 107篇 |
眼科学 | 23篇 |
药学 | 126篇 |
中国医学 | 7篇 |
肿瘤学 | 94篇 |
出版年
2023年 | 12篇 |
2022年 | 45篇 |
2021年 | 56篇 |
2020年 | 28篇 |
2019年 | 41篇 |
2018年 | 38篇 |
2017年 | 34篇 |
2016年 | 51篇 |
2015年 | 51篇 |
2014年 | 62篇 |
2013年 | 84篇 |
2012年 | 111篇 |
2011年 | 102篇 |
2010年 | 64篇 |
2009年 | 35篇 |
2008年 | 56篇 |
2007年 | 55篇 |
2006年 | 61篇 |
2005年 | 56篇 |
2004年 | 40篇 |
2003年 | 29篇 |
2002年 | 32篇 |
2001年 | 38篇 |
2000年 | 25篇 |
1999年 | 14篇 |
1998年 | 5篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1992年 | 5篇 |
1991年 | 10篇 |
1990年 | 10篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 6篇 |
1985年 | 3篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1979年 | 4篇 |
1978年 | 6篇 |
1977年 | 3篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 11篇 |
1968年 | 4篇 |
1967年 | 2篇 |
排序方式: 共有1342条查询结果,搜索用时 15 毫秒
71.
Somnath Saha Saibal Mishra D. D. Chakraborty Subhabrata Sengupta A. R. Mondal 《Indian journal of otolaryngology and head and neck surgery》2008,60(1):37-40
Foreign body impaction in aero digestive tract in infancy is difficult to diagnose sometimes. In this review of five unusual
cases of occult foreign body impaction in aero digestive tract has been presented and their management discussed 相似文献
72.
D Mahalanabis R B Sack J Kaplan B Jacobs A Mondal 《Bulletin of the World Health Organization》1970,42(6):837-846
Because of the relative difficulty in maintaining continuous intravenous infusions in small children suffering from cholera, a simpler method of maintenance fluid therapy would be useful. With this in mind, the role of intraperitoneal fluid administration was evaluated in 8 adults and 26 children (aged 6 years or less) having moderate to severe cholera or cholera-like diarrhoeal disease. 相似文献
73.
Jahangir T Khan TH Prasad L Sultana S 《The Journal of pharmacy and pharmacology》2005,57(9):1199-1204
Cadmium intoxication induces lipid peroxidation and causes oxidative damage to various tissues by altering antioxidant defence system enzymes. At 24 h after treatment with a single intraperitoneal dose of cadmium chloride (5 mg kg-1), Swiss albino mice showed a significant increase in the levels of malanodialdehyde and xanthine oxidase (P<0.001), and a concomitant depletion of renal glutathione, catalase (P<0.001) and other antioxidant enzymes. CdCl2 also led to a simultaneous increase in micronuclei formation (P<0.001) and chromosomal aberrations (P<0.05) in mouse bone marrow cells. Oral pre-treatment with Pluchea lanceolata extract at doses of 100 and 200 mg kg-1 for 7 consecutive days before CdCl2 intoxication caused a significant reduction in malanodialdehyde formation and xanthine oxidase activity (P<0.001). A significant restoration of the activity of antioxidant defence system enzymes such as catalase, glutathione peroxidase (P<0.05), glutathione-S-transferase and glutathione reductase (P<0.001) was observed. A significant dose-dependent decrease in chromosomal aberrations and micronuclei formation was also observed (P<0.05). The results indicate that pre-treatment with P. lanceolata attenuates cadmium chloride induced oxidative stress and genotoxicity by altering antioxidant enzymes and reducing chromatid breaks and micronuclei formation. 相似文献
74.
Liu XK Yamada S Kane GC Alekseev AE Hodgson DM O'Cochlain F Jahangir A Miki T Seino S Terzic A 《Diabetes》2004,53(Z3):S165-S168
Metabolic-sensing ATP-sensitive K+ channels (KATP channels) adjust membrane excitability to match cellular energetic demand. In the heart, KATP channel activity has been linked to homeostatic shortening of the action potential under stress, yet the requirement of channel function in securing cardiac electrical stability is only partially understood. Here, upon catecholamine challenge, disruption of KATP channels, by genetic deletion of the pore-forming Kir6.2 subunit, produced defective cardiac action potential shortening, predisposing the myocardium to early afterdepolarizations. This deficit in repolarization reserve, demonstrated in Kir6.2-knockout hearts, translated into a high risk for induction of triggered activity and ventricular dysrhythmia. Thus, intact KATP channel function is mandatory for adequate repolarization under sympathetic stress providing electrical tolerance against triggered arrhythmia. 相似文献
75.
Nipah virus encephalitis reemergence, Bangladesh 总被引:13,自引:0,他引:13
Hsu VP Hossain MJ Parashar UD Ali MM Ksiazek TG Kuzmin I Niezgoda M Rupprecht C Bresee J Breiman RF 《Emerging infectious diseases》2004,10(12):2082-2087
We retrospectively investigated two outbreaks of encephalitis in Meherpur and Naogaon, Bangladesh, which occurred in 2001 and 2003. We collected serum samples from persons who were ill, their household contacts, randomly selected residents, hospital workers, and various animals. Cases were classified as laboratory confirmed or probable. We identified 13 cases (4 confirmed, 9 probable) in Meherpur; 7 were in persons in two households. Patients were more likely than nonpatients to have close contact with other patients or have contact with a sick cow. In Naogaon, we identified 12 cases (4 confirmed, 8 probable); 7 were in persons clustered in 2 households. Two Pteropus bats had antibodies for Nipah virus. Samples from hospital workers were negative for Nipah virus antibodies. These outbreaks, the first since 1999, suggest that transmission may occur through close contact with other patients or from exposure to a common source. Surveillance and enhancement of diagnostic capacity to detect Nipah virus infection are recommended. 相似文献
76.
Mondal U Ganesan M Pal TK Jayakumar M Chattaraj TK Roy K Banerjee SN 《Journal of the Indian Medical Association》2004,102(1):26, 28, 30
The newly developed proton pump inhibitor rabeprazole sodium is expected to have beneficial effects in the treatment of peptic ulcer. The pharmacokinetic parameters (C(max), AUC(o-t), t(max)) of this drug have been evaluated to compare the single dose (20 mg) bioavailability of rabeprazole sodium with the standard reference. High performance liquid chromatography (HPLC) coupled with UV detector set at 280 nm has been used to determine plasma concentration of 12 human volunteers as per Drugs Controller General of India (DCGI) guidelines. The method has been validated over a linear range of 20-480 ng/ml from plasma. The minimum quantifiable concentration was set at 10 ng/ml [co-efficient of variance (CV) < 10%]. By comparing AUC(o-t) the relative bioavailability of test preparation has been found to be 100.88% of that of reference preparation. 相似文献
77.
An experiment was conducted to investigate the changes in peripheral plasma FSH concentrations in relation to expression of estrus in Sahiwal cows. Out of total five estrus, three were accompanied by overt signs whereas rest two were silent estrus. In cows with overt estrus, plasma FSH concentrations during periestrus, early luteal, midluteal and late luteal phase were 1.65+/-0.34, 1.67+/-0.21, 1.58+/-0.18 and 1.69+/-0.31 ng/ml, respectively and the corresponding values in cows with silent estrus being 0.68+/-0.39, 0.50+/-0.12, 0.75+/-0.13 and 0.46+/-0.12 ng/ml, respectively. The overall plasma FSH levels in cows that exhibited overt estrus was 1.63+/-0.82 ng/ml as against 0.64+/-0.55 ng/ml in silent estrus. It was concluded that FSH levels were higher (P<0.01) in cows that exhibited overt estrus compared to silent estrus. 相似文献
78.
79.
Mondal B Hosamani M Dutta TK Senthilkumar VS Rathore R Singh RK 《Revue scientifique et technique (International Office of Epizootics)》2004,23(3):943-949
An outbreak of sheep pox occurred in December 2001 on a sheep breeding farm in Jammu, India. The farm maintains three exotic breeds of sheep, i.e. American Merino, Rambouillet and Australian cross. The disease agent was confirmed as sheep pox virus by clinical and post-mortem examination as well as laboratory testing. Typical pock lesions were dispersed over the body of the affected animals with nodular lesions observed in the lung tissue of the dead animals. Sheep pox virus antigen and antibody were detected in infected tissue and convalescent sera, respectively, with serological tests. Viral deoxyribonucleic acid was extracted from the infected tissue and amplified using a diagnostic polymerase chain reaction. Sheep of the Rambouillet breed were found to be most susceptible to infection with morbidity and mortality rates of 26.9% and 8.3%, respectively. Morbidity and mortality rates in the entire flock were 18.4% and 6.3%, respectively. The grazing and migration pattern indicates that the disease was probably introduced to the farm by local sheep. 相似文献
80.
Jahangir AR McClung WG Cornelius RM McCloskey CB Brash JL Santerre JP 《Journal of biomedical materials research》2002,60(1):135-147
Polyether-urethanes (PEUs) have been the materials of choice for the manufacture of conventional blood-contacting devices. Nevertheless, biostability and blood compatibility are still among the principal limitations in their long-term application. Studies investigating the development of protective coatings for PEUs have shown that degradation can be reduced with the use of fluorinated surface-modifying macromolecules (SMMs). It has also been hypothesized that SMM-modified PEU surfaces may exhibit improved blood compatibility because other studies have shown a modulation in fibrinogen adsorption onto these surfaces. To determine the blood compatibility of a PEU-containing fluorinated SMMs, a series of in vitro experiments were designed to study the pattern of protein adsorption from plasma and then to assess the nature of platelet adhesion and activation on each substrate. Western blot analysis as well as single protein studies revealed that the dominant "adhesive proteins" [fibrinogen (Fg), fibronectin (Fnc), and vitronectin (Vnc)] were adsorbed on two of the SMM-containing PEUs in lower amounts relative to unmodified base. Platelet adhesion and activation data further highlighted the differences among the various substrates. It was shown that the unmodified base had a higher number of adhered platelets relative to the SMM-modified surfaces, and that of the SMM-containing substrates, which showed the lowest levels of adhesive proteins also, exhibited significantly lower platelet densities. Close morphological examination further revealed that platelets residing on these latter substrates were not appreciably activated. Based on the current evidence, it is believed that the fluorinated SMMs demonstrate good potential for the development of surfaces with minimal thrombogenic character in in vivo applications. 相似文献