全文获取类型
收费全文 | 89篇 |
免费 | 9篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 8篇 |
口腔科学 | 2篇 |
临床医学 | 41篇 |
内科学 | 34篇 |
皮肤病学 | 2篇 |
神经病学 | 1篇 |
外科学 | 2篇 |
预防医学 | 3篇 |
药学 | 2篇 |
肿瘤学 | 1篇 |
出版年
2023年 | 1篇 |
2017年 | 1篇 |
2016年 | 7篇 |
2015年 | 5篇 |
2014年 | 10篇 |
2013年 | 16篇 |
2012年 | 3篇 |
2011年 | 5篇 |
2010年 | 12篇 |
2009年 | 5篇 |
2008年 | 2篇 |
2007年 | 1篇 |
2003年 | 1篇 |
2000年 | 3篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1979年 | 1篇 |
1959年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有98条查询结果,搜索用时 25 毫秒
61.
PATRICK W. SERRUYS M. D. FELIX ZIJLSTRA M. D. HANS H. C. REIBER M. D. RENE KONING M.D. JOS ROELANDT M. D. 《Journal of interventional cardiology》1988,1(1):19-33
Intracoronary blood flow velocity measurements with a Doppler probe and the radiographic assessment of myocardial perfusion with contrast media previously have been used to investigate regional coronary flow reserve. In the present study we applied both techniques in the same patients to measure the immediate improvement in coronary flow reserve as a result of angioplasty. In addition we compared papaverine induced hyperemia with reactive hyperemia following transient transluminal occlusion of a major coronary artery. In 13 consecutive patients with a single proximal stenosis, coronary flow reserve was measured pre- and postangioplasty by digital subtraction cineangiography, while pre- and postangioplasty Doppler measurements before and after papaverine were obtained in the proximal part of the stenotic vessel. After the last transluminal occlusion, reactive hyperemia recorded with the Doppler probe was also compared to the coronary flow reserve measurement obtained during papaverine induced hyperemia. As a result of the angioplasty, coronary flow reserve measured with the radiographic technique (mean ± SD) increased from 1.1 ± 0.4 to 2.2 ± 0.4 (P < 0.001), while coronary flow reserve measured with the Doppler probe (mean ± SD) increased from 1.2 ± 0.3 to 2.4 ± 0.4 (P < 0.001). Pharmacologically induced hyperemia measured with the radiographic technique and the Doppler probe were linearly related (r = 0.91 with a SEE 0.3) and confirmed the reliability of the intracoronary measurements. Using these two independent techniques, coronary flow reserve immediately after angioplasty was found to be substantially improved but still abnormal. In addition, the magnitude of hyperemia induced by papaverine was comparable to the reactive hyperemia following transluminal occlusion, although the latter measurement was recorded with the angioplasty catheter still across the dilated lesion. (J Interven Cardiol, 1988:1:1) 相似文献
62.
CLAUDIA YPENBURG M.D. NICO VAN DE VEIRE Ph.D. JOS J. WESTENBERG GABE B. BLEEKER M.D. NINA AJMONE MARSAN M.D. MAUREEN M. HENNEMAN M.D. ERNST E. VAN DER WALL Ph.D. MARTIN J. SCHALIJ Ph.D. THEODORE P. ABRAHAM Ph.D. S. SERGE BAROLD M.D. JEROEN J. BAX M.D. 《Pacing and clinical electrophysiology : PACE》2008,31(12):1628-1639
Cardiac resynchronization therapy (CRT) has become a therapeutic option for drug‐refractory heart failure. Several noninvasive imaging techniques play an increasingly important role before and after device implantation. This review highlights the acute and long‐term CRT benefits after implantation as assessed with echocardiography and nuclear imaging. Furthermore, optimization of CRT settings, in particular atrioventricular and interventricular delay, will be discussed using echocardiography and other (device‐based) techniques. 相似文献
63.
The Role of Conventional and Right‐Sided ECG Screening for Subcutaneous ICD in a Tetralogy of Fallot Population
下载免费PDF全文
![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
64.
An Automatic Algorithm Based on Morphological Stability During Fast Ventricular Arrhythmias Predicts Successful Antitachycardia Pacing in ICD Patients: A Multicenter Study
下载免费PDF全文
![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
ROBERTO MATÍA M.D. ANTONIO HERNÁNDEZ‐MADRID M.D. GONZALO SÁNCHEZ‐HUETE JOSÉ BAUTISTA MARTÍNEZ‐FERRER M.D. JAVIER ALZUETA M.D. XAVIER VIÑOLAS M.D. JERÓNIMO RUBIO M.D. JOSÉ MANUEL PORRES M.D. ANÍBAL RODRÍGUEZ M.D. ENRIQUE GARCÍA M.D. IGNACIO FERNÁNDEZ‐LOZANO M.D. I MIGUEL ÁLVAREZ M.D. JAVIER MORENO M.D. 《Pacing and clinical electrophysiology : PACE》2016,39(7):633-641
65.
JOS SNOECK MARC BERKHOF MARC CLAEYS CHRIS VRINTS JOHAN BOSMANS HANS DECOSTER HILDE HEUTEN 《Pacing and clinical electrophysiology : PACE》1992,15(11):1841-1845
The change of the pacing rate in response to external vibration interference was assessed in four rate responsive pacemakers with a piezoelectric crystal (Medtronic Activitrax 8403, Siemens Sensolog 3, Biotronik Ergos 01, and Medtronic Legend 8417) and one with an accelerometer (CPI Excel VR 1119). They were tested in the laboratory. External vibration was simulated in vitro by exposing the different pacemakers to a controlled sinusoidal vibration force generated by a Millar pressure vibration amplifier type MGM-30 (Millar Instruments, Inc., Houston, TX, USA). All pacemakers were programmed at standard settings. Two types of vibration forces were applied: (1) one with varying amplitude but with constant vibration frequency; and (2) one with varying frequency but with constant vibration amplitude. In this manner curves of pacing rate versus vibration forces versus vibration frequency were obtained. High vibration forces and low vibration frequencies were associated with the highest pacing rate response. In this experimental setting, the pacemaker based on the accelerometer principle apparently was the least sensitive to high frequency vibrations, which are known to be related to environmental interference. It also seemed more appropriately responsive in the lower frequency range, which is more appropriate for the detection of true physiological activity. 相似文献
66.
JOS HERBERGS ANTON H. N. HOPMAN ADRIAAN P. DE BRUÏNE FRANS C. S. RAMAEKERS JAN-WILLEM ARENDS 《The Journal of pathology》1996,179(3):243-247
Chromosomal aberrations in colonic tumourigenesis were investigated by fluorescence in situ hybridization (FISH) with centromere-specific DNA probes and correlated to flow cytometry (FCM) results in a series of tissues including normal colonic epithelium, adenomas, and carcinomas, as well as adenomas adjacent to carcinomas. No numerical chromosome aberrations were detected in normal colonic epithelium, except for an extra chromosome X in one case. In the adenomas, the most frequently occurring chromosome aberration was a trisomy for chromosome 7, occurring in 37 per cent of the cases. In the carcinomas, two distinct routes of genetic aberration could be established on the basis of correlation with FCM: one with and one without endoreduplication. In the carcinomas without endoreduplication, trisomy or tetrasomy for chromosome 7 was detected in 12 out of 15 cases (80 per cent). In three of these cases, trisomy 7 was found in combination with loss of chromosome 17 and/or chromosome 18. In 87 per cent of the carcinomas with endoreduplication, loss of chromosome 17 and/or 18 was found, while in only one case was gain of chromosome 7 detected. In the adenomas adjacent to carcinomas, trisomy 7 was found in 36 per cent of the cases. In these cases, the concomitant adenocarcinomas showed the same numerical chromosome 7 aberration, plus extra aberrations for other chromosomes. In only two cases the carcinoma demonstrated trisomy 7 with a normal adjacent adenoma. These results suggest that gain of chromosome 7 is a significant aberration in the tumourigenesis of colonic carcinomas in which no endoreduplication has occurred. No marked clinico-pathological differences were observed between tumours of either route of tumourigenesis in this series. 相似文献
67.
DOMINGO PALACIOS-CEÑA RN PhD JOSÉ MIGUEL CACHÓN-PÉREZ RN MSc DANIEL GÓMEZ-PÉREZ RN MSc CRISTINA GÓMEZ-CALERO OT MSc MIGUEL BREA-RIVERO OT MSc CÉSAR FERNÁNDEZ-DE-LAS-PEÑAS PT PhD 《Journal of nursing management》2013,21(8):1044-1052
palacios-ceña d., cachón-pérez j.m., gómez-pérez d., gómez-calero c., brea-rivero m. & fernández-de-las-peñas c. (2012) Journal of Nursing Management
Is the influence of nurse care practices and nursing home organization understood? A qualitative study Aim To describe residents’ experience of nursing home organization and nursing care practices in a region of Spain. Background Nursing home organization, nursing practices and rules within the institution may all influence residents’ daily living and their perception on the quality of care provided. Design A qualitative approach was conducted, using purposeful and theoretical sampling. Data were collected from nursing home residents, following unstructured and semi-structured interviews, researcher field notes and residents’ personal diaries and letters. Giorgi analysis was conducted. Results Two main themes emerged. (1) ‘Following nursing home rules’. Norms may be seen as boundaries, especially for those residents who were independent before admission. (2) ‘Prioritizing nursing care in residents’. Prioritizing the nursing care may limit the autonomy of residents because it does not meet their preferences and needs. Conclusion Understanding the meaning of nursing home organization and nursing care practices with nursing home residents might provide deeper insight into their expectations. Implications for nursing management Nursing staff should have greater involvement in the nursing home organization, as well as in prioritizing the care provision based on resident’s needs and preferences. 相似文献
Is the influence of nurse care practices and nursing home organization understood? A qualitative study Aim To describe residents’ experience of nursing home organization and nursing care practices in a region of Spain. Background Nursing home organization, nursing practices and rules within the institution may all influence residents’ daily living and their perception on the quality of care provided. Design A qualitative approach was conducted, using purposeful and theoretical sampling. Data were collected from nursing home residents, following unstructured and semi-structured interviews, researcher field notes and residents’ personal diaries and letters. Giorgi analysis was conducted. Results Two main themes emerged. (1) ‘Following nursing home rules’. Norms may be seen as boundaries, especially for those residents who were independent before admission. (2) ‘Prioritizing nursing care in residents’. Prioritizing the nursing care may limit the autonomy of residents because it does not meet their preferences and needs. Conclusion Understanding the meaning of nursing home organization and nursing care practices with nursing home residents might provide deeper insight into their expectations. Implications for nursing management Nursing staff should have greater involvement in the nursing home organization, as well as in prioritizing the care provision based on resident’s needs and preferences. 相似文献
68.
THOMAS J. VAN BRAKEL M.D. Ph .D. JJ ROB HERMANS Ph .D.† RYAN E. ACCORD M.D. ULRICH SCHOTTEN M.D. Ph .D.‡ JOS FM. SMITS Ph .D.† MAURITS A. ALLESSIE M.D. Ph .D.‡ JOS G. MAESSEN M.D. Ph .D. 《Journal of cardiovascular electrophysiology》2009,20(2):207-215
Introduction: Intrapericardial (IPC) delivery of antiarrhythmic agents is an appealing idea to increase the therapeutic width and reduce side effects of drugs, particularly in the thin atria. The aim of this study was to determine the effects of IPC versus intravenous (IV) d,l-sotalol and flecainide infusion on transmural atrial electrophysiology and sustained atrial fibrillation (AF) in the goat.
Methods and Results: Effects of IPC and IV sotalol and flecainide infusion on epi- and endocardial atrial electrophysiology, ECG, and tissue drug concentrations were studied in goats without and with persistent AF (>24 hours). Epicardial atrial refractory period (AERP, bcl 400 ms) increased after 120 minutes of 1 mg/kg/hour IPC sotalol with 61 ± 8 ms (P = 0.02), whereas the endocardial AERP was not affected. One mg/kg/hour IPC flecainide increased the epicardial pacing threshold and the epicardial AERP with 4 ± 0.5 mA (P = 0.003) and 33 ± 11 ms (P = 0.05), respectively. Endocardial values were unchanged. Marked ST-elevations in the precordial ECG leads were observed after IPC flecainide. In the AF group, IPC drugs did not prolong AF cycle length to a greater extent than IV delivery. The number of cardioversions was not different between the two delivery routes. A steep transmural drug concentration gradient after IPC sotalol and flecainide was observed in all heart chambers.
Conclusion: IPC sotalol and flecainide infusion in goats markedly affects epicardial atrial electrophysiology. IPC delivery, however, does not prolong AFCL or terminate AF to a greater extent than IV infusion. This suggests that the perpetuation of AF is not dominated by the epicardial and sub epicardial atrial layers. 相似文献
Methods and Results: Effects of IPC and IV sotalol and flecainide infusion on epi- and endocardial atrial electrophysiology, ECG, and tissue drug concentrations were studied in goats without and with persistent AF (>24 hours). Epicardial atrial refractory period (AERP, bcl 400 ms) increased after 120 minutes of 1 mg/kg/hour IPC sotalol with 61 ± 8 ms (P = 0.02), whereas the endocardial AERP was not affected. One mg/kg/hour IPC flecainide increased the epicardial pacing threshold and the epicardial AERP with 4 ± 0.5 mA (P = 0.003) and 33 ± 11 ms (P = 0.05), respectively. Endocardial values were unchanged. Marked ST-elevations in the precordial ECG leads were observed after IPC flecainide. In the AF group, IPC drugs did not prolong AF cycle length to a greater extent than IV delivery. The number of cardioversions was not different between the two delivery routes. A steep transmural drug concentration gradient after IPC sotalol and flecainide was observed in all heart chambers.
Conclusion: IPC sotalol and flecainide infusion in goats markedly affects epicardial atrial electrophysiology. IPC delivery, however, does not prolong AFCL or terminate AF to a greater extent than IV infusion. This suggests that the perpetuation of AF is not dominated by the epicardial and sub epicardial atrial layers. 相似文献
69.
DIANA HERNÁNDEZ‐ROMERO Ph.D. FRANCISCO MARÍN M.D. Ph.D. VANESSA ROLDÁN M.D. Ph.D. PABLO PEÑAFIEL M.D. JUAN ANTONIO VILCHEZ B.Sc. Pharm. ESTEBAN ORENES‐PIÑERO Ph.D. JOSÉ ANTONIO GINER M.D. MARIANO VALDÉS M.D. Ph.D. ARCADIO GARCÍA‐ALBEROLA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2013,36(1):31-36