全文获取类型
收费全文 | 3197篇 |
免费 | 193篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 71篇 |
妇产科学 | 80篇 |
基础医学 | 592篇 |
口腔科学 | 110篇 |
临床医学 | 284篇 |
内科学 | 705篇 |
皮肤病学 | 47篇 |
神经病学 | 337篇 |
特种医学 | 81篇 |
外科学 | 179篇 |
综合类 | 28篇 |
一般理论 | 1篇 |
预防医学 | 241篇 |
眼科学 | 59篇 |
药学 | 298篇 |
中国医学 | 20篇 |
肿瘤学 | 255篇 |
出版年
2024年 | 4篇 |
2023年 | 28篇 |
2022年 | 117篇 |
2021年 | 183篇 |
2020年 | 95篇 |
2019年 | 114篇 |
2018年 | 112篇 |
2017年 | 78篇 |
2016年 | 119篇 |
2015年 | 110篇 |
2014年 | 169篇 |
2013年 | 192篇 |
2012年 | 284篇 |
2011年 | 314篇 |
2010年 | 164篇 |
2009年 | 101篇 |
2008年 | 222篇 |
2007年 | 191篇 |
2006年 | 198篇 |
2005年 | 163篇 |
2004年 | 138篇 |
2003年 | 115篇 |
2002年 | 96篇 |
2001年 | 13篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 10篇 |
1997年 | 7篇 |
1996年 | 4篇 |
1995年 | 7篇 |
1994年 | 9篇 |
1993年 | 4篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1970年 | 2篇 |
排序方式: 共有3409条查询结果,搜索用时 15 毫秒
31.
32.
Wendy van Dorp Ivana M.M. van der Geest Joop S.E. Laven Wim C.J. Hop Sebastian J.C.M.M. Neggers Andrica C.H. de Vries Rob Pieters Marry M. van den Heuvel-Eibrink 《European journal of cancer (Oxford, England : 1990)》2013,49(6):1280-1286
BackgroundAlthough gonadal toxicity has been reported, no data are available on recovery of gonadal function in very long-term survivors of childhood cancer. Inhibin B is a novel reliable serum marker which has been shown to be of value in childhood cancer survivor studies to identify risk groups for impaired gonadal function, but consecutive long-term follow-up studies using serum inhibin B as a marker are not available.ObjectiveTo evaluate possible recovery of gonadal dysfunction over time in adult male survivors of childhood cancer.MethodsIn this retrospective study, adult male long-term childhood cancer survivors (n = 201) who visited our outpatient late effects clinic were included and we used inhibin B as a surrogate marker for gonadal function.ResultsMedian age at diagnosis was 5.9 years (range 0.0–17.5) and discontinuation of treatment was reached at a median age of 8.2 years (range 0.0–20.8). Inhibin B levels were first measured after a median follow-up time of 15.7 years (range 3.0–37.0). Median interval between the first (T1) and second measurement (T2) was 3.3 years (range 0.7–11.3). Median inhibin B level was 127 ng/L (range 5–366) at T1 and 155 ng/L (range 10–507) at T2. The prediction model suggests that inhibin B levels do not normalise in survivors with a very low Inhibin B level at T1.ConclusionsOur results suggest that recovery of gonadal function is possible even long after discontinuation of treatment. However, this recovery does not seem to occur in survivors who already reached critically low inhibin B levels after discontinuation of treatment. 相似文献
33.
Ivica Matak Ivana Stracenski Zdravko Lacković 《Journal of neural transmission (Vienna, Austria : 1996)》2013,120(1):141-144
Long-term effectiveness and repeated administration of botulinum toxin A are the basis for its use in both neuromuscular disorders and certain painful conditions. Botulinum toxin A has been recently approved for migraine treatment, and its off-label use extends to other craniofacial pain disorders. However, recently it was reported that, after repeated injection, botulinum toxin loses its antinociceptive efficacy in rats. In present study with a similar design, we compared the effects of single and repeated injections of botulinum toxin in formalin-induced orofacial pain. No statistically significant differences were found between single or repeatedly treated animal groups. Our results are in line with the clinical experience and suggest that botulinum toxin can be re-administered in orofacial pain treatment. 相似文献
34.
35.
Jana Maslankova Ivana Vecurkovska Miroslava Rabajdova Jana Katuchova Milos Kicka Michala Gayova Vladimir Katuch 《World journal of gastroenterology : WJG》2022,28(33):4744-4761
According to data from 2020, Slovakia has long been among the top five countries with the highest incidence rate of colorectal cancer (CRC) worldwide, and the rate is continuing to rise every year. In approximately 80% of CRC cases, allelic loss (loss of heterozygosity, LOH) occurs in the long arm of chromosome 18q. The most important genes that can be silenced by 18q LOH or mutations are small mothers against decapentaplegic homolog (SMAD) 2 and SMAD4, which are intracellular mediators of transforming growth factor (TGF)-β superfamily signals. TGF-β plays an important role in the pro-oncogenic processes, including such properties as invasion, epithelial-mesenchymal transition (commonly known as EMT), promotion of angiogenesis, and immunomodulatory effects. Several recent studies have reported that activation of TGF-β signaling is related to drug resistance in CRC. Because the mechanisms of drug resistance are different between patients in different stages of CRC, personalized treatment is more effective. Therefore, knowledge of the activation and inhibition of factors that affect the TGF-β signaling pathway is very important. 相似文献
36.
37.
Diaz LA Spinsanti LI Almiron WR Contigiani MS 《Revista do Instituto de Medicina Tropical de S?o Paulo》2003,45(2):109-110
Una virus (UNAV), Togaviridae family, is widely distributed in South America, where infections have been detected in mosquitoes and vertebrate hosts (humans, birds and horses). We analyzed human sera from Córdoba inhabitants aged 44 to 89 years and using a neutralization test, we found a prevalence of UNAV antibodies of 3.8% (3/79). The low titers detected suggest past infections probably acquired in rural areas of the Province of Córdoba (central Argentina). None sera were found positive for MAYV neutralizing antibodies. This is the first report of human infections by UNAV in Argentina. 相似文献
38.
39.
Rissanen TT Korpisalo P Markkanen JE Liimatainen T Ordén MR Kholová I de Goede A Heikura T Gröhn OH Ylä-Herttuala S 《Circulation》2005,112(25):3937-3946
40.
Dunić I Djurković-Djaković O Vesić S Zerjav S Jevtović D 《International journal of STD & AIDS》2005,16(7):475-478
A prospective study to evaluate the incidence of herpes zoster (HZ) as an immune restoration disease in patients with AIDS during highly active antiretroviral therapy (HAART) was conducted in a series of 115 patients diagnosed with AIDS initiated on HAART between 1 January 2000 and 31 July 2001. Of these, a single dermatomal HZ episode occurred in 14 (12%) patients within one and 15 months of HAART (median eight months). The HZ patients were similar to the non-HZ patients in age, sex, and HIV transmission risk factor, but had a more advanced disease. Compared with the baseline values, the viral loads significantly (P<0.01) decreased, while the mean CD4+ T-cell counts increased by almost four-fold (P<0.01) in both groups at the time of the HZ episode (or equivalent in non-HZ), but remained below 400/mL in the HZ patients. HZ during HAART is an immunopathological consequence of the improvement of the host immuneresponse, correlating with the beginning of immune restoration. 相似文献