全文获取类型
收费全文 | 2102篇 |
免费 | 131篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 79篇 |
妇产科学 | 53篇 |
基础医学 | 257篇 |
口腔科学 | 102篇 |
临床医学 | 138篇 |
内科学 | 481篇 |
皮肤病学 | 39篇 |
神经病学 | 128篇 |
特种医学 | 26篇 |
外国民族医学 | 1篇 |
外科学 | 299篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 252篇 |
眼科学 | 42篇 |
药学 | 149篇 |
中国医学 | 12篇 |
肿瘤学 | 138篇 |
出版年
2023年 | 17篇 |
2022年 | 37篇 |
2021年 | 70篇 |
2020年 | 38篇 |
2019年 | 61篇 |
2018年 | 87篇 |
2017年 | 58篇 |
2016年 | 64篇 |
2015年 | 96篇 |
2014年 | 108篇 |
2013年 | 98篇 |
2012年 | 155篇 |
2011年 | 186篇 |
2010年 | 94篇 |
2009年 | 89篇 |
2008年 | 148篇 |
2007年 | 142篇 |
2006年 | 126篇 |
2005年 | 96篇 |
2004年 | 83篇 |
2003年 | 71篇 |
2002年 | 57篇 |
2001年 | 31篇 |
2000年 | 38篇 |
1999年 | 24篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1992年 | 9篇 |
1991年 | 13篇 |
1990年 | 10篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 10篇 |
1986年 | 15篇 |
1985年 | 6篇 |
1984年 | 12篇 |
1982年 | 2篇 |
1980年 | 5篇 |
1977年 | 2篇 |
1974年 | 4篇 |
1972年 | 2篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 2篇 |
1968年 | 2篇 |
1967年 | 5篇 |
1966年 | 5篇 |
1965年 | 4篇 |
排序方式: 共有2245条查询结果,搜索用时 11 毫秒
101.
102.
Neil D. Patel Damien Kenny Ismael Gonzalez Zahid Amin Michel N. Ilbawi Ziyad M. Hijazi 《Pediatric cardiology》2014,35(3):419-422
Although catheter-based intervention is generally accepted as the treatment of choice for branch pulmonary artery (PA) stenosis, there are no data directly comparing both the need for reintervention and time to reintervention in patients undergoing transcatheter stenting versus surgical arterioplasty. We compared children who underwent surgical branch pulmonary arterioplasty and branch PA stent placement between January 2008 and May 2012 at a single tertiary center. Need for reintervention and mean time to reintervention were assessed using chi-square and independent sample Student t test. Thirty-seven patients were included (surgery n = 18, stent n = 19). Mean weight at initial intervention was 11.3 ± 8.8 kg for surgical and 20.1 ± 15.5 kg for stent (p = 0.041). Intervention was performed on the left PA in 17 patients, the right PA in 12 patients, and both PAs in 8 patients. Five patients had undergone previous intervention. On mean follow-up of 807 ± 415 days, 50 % (9 of 18) of the surgery cohort and 5.3 % (1 of 19) of the stent cohort required reintervention (p = 0.002). In all but one case reintervention was catheter-based. Mean time to reintervention for the surgery cohort was 272 ± 162 days and for the single stent cohort it was 150 days. When comparable age and weight groups were analyzed, reintervention was still more common in the surgery cohort (p = 0.007). Children undergoing surgical branch pulmonary arterioplasty are more likely to require reintervention than those undergoing stent placement. 相似文献
103.
Frequent coexistence of RAS mutations in RUNX1‐mutated acute myeloid leukemia in Arab Asian children
Lika'a Fasih Y. Al‐Kzayer MD PhD Kazuo Sakashita MD PhD Mazin Faisal Al‐Jadiry MD Salma Abbas Al‐Hadad MD Le T.N. Uyen MD Tingting Liu MD Kazuyuki Matsuda PhD Jaafar M.H. Abdulkadhim MD Tariq Abadi Al‐Shujairi MD Zead Ismael I.K. Matti MD Janan Ghalib Hasan MD Hussam M. Salih Al‐Abdullah MD Toshi Inoshita MD Minoru Kamata MD Maher A. Sughayer MD Faris F. Madanat MD Kenichi Koike MD PhD 《Pediatric blood & cancer》2014,61(11):1980-1985
104.
Eduardo Bartholomay Ismael Polli Anibal Pires Borges Carlos Kalil André Arroque Ilmar Kohler Luiz Cláudio Danzmann 《Clinics (S?o Paulo, Brazil)》2014,69(9):615-620
OBJECTIVES:
Atrial fibrillation is the most common sustained arrhythmia and is associated with poor outcomes, including stroke. The ability of anticoagulation therapy to reduce the risk of stroke has been well established; however, the prevalence of anticoagulation therapy use in the Public Health System is unknown. The aim of this study is to evaluate both the prevalence of anticoagulation therapy among patients with atrial fibrillation and the indications for the treatment.METHODS:
In this cross-sectional study, we included consecutive patients who had atrial fibrillation documented by an electrocardiogram performed between September 2011 and March 2012 at a university hospital of the Public Health System. The variables analyzed included the risk of a thromboembolic event and/or bleeding, the use of antiplatelet or anticoagulation therapy, the location where the electrocardiogram report was initially reviewed and the specialty of the physician who initially reviewed it.RESULTS:
We included 162 patients (mean age 68.9 years, 56% men). Hypertension (90.1%), heart failure (53.4%) and stroke (38.9%) were the most prevalent diseases found. Only 50.6% of the patients knew that they had atrial fibrillation. Regarding the use of therapy, only 37.6% of patients classified as high risk according to the CHADS2 scores and 35.5% according to the CHA2DS2VASc used oral anticoagulation. A presumptive diagnosis of heart failure and the fact that the electrocardiogram was evaluated by a cardiologist were the only independent predictors of the use of anticoagulants.CONCLUSIONS:
Our study found a low prevalence of oral anticoagulation therapy among patients with atrial fibrillation and an indication for stroke prophylaxis for the use of this therapy, including among those with high CHADS2 and CHA2DS2VASc scores. 相似文献105.
Dietary Sodium and Potassium Intake: Data from the Mexican National Health and Nutrition Survey 2016
Jorge Vargas-Meza Manuel A. Cervantes-Armenta Ismael Campos-Nonato Claudia Nieto Joaquín Alejandro Marrn-Ponce Simn Barquera Mario Flores-Aldana Sonia Rodríguez-Ramírez 《Nutrients》2022,14(2)
Population studies have demonstrated an association between sodium and potassium intake and blood pressure levels and lipids. The aim of this study was to describe the dietary intake and contribution of sodium and potassium to the Mexican diet, and to describe its association with nutrition status and clinical characteristics. We analyzed a national survey with 4219 participants. Dietary information was obtained with a 24-h recall. Foods and beverages were classified according to level of processing. The mean intake (mg/d) of Na was 1512 in preschool children, 2844 in school-age children, 3743 in adolescents, and 3132 in adults. The mean intake (mg/d) of K was 1616 in preschool children, 2256 in school-age children, 2967 in adolescents, and 3401 in adults. Processed and ultra-processed foods (UPF) contribute 49% of Na intake in preschool children, 50% in school-age children, 47% in adolescents, and 39% in adults. Adults with high Na intake had lower serum concentrations of cholesterol, HDL-c, and LDL-c. A significant proportion of the Mexican population has a high intake of Na (64–82%) and low K (58–73%). Strategies to reduce Na and increase K intake need to reduce the possibility of having high BP and serum lipid disturbances. 相似文献
106.
Hani N. Mufti Ahmed A. Rabie Alyaa M. Elhazmi Husam A. Bahaudden Mostafa A. Rajab Ismael S. Al Enezi Ayed Y. Assiri Khalid A. Maghrabi Ali A. Al Bshabshe Abdullah M. Abudayah Adel A. Tash Awad A. Al-Omari Mohamed H. Azzam 《Saudi medical journal》2021,42(6):589
Extracorporeal membrane oxygenation (ECMO) is considered as a supportive treatment that provides circulatory and ventilatory support and can be thought off as a bridge to organ recovery. Since 2009, it has been applied as a rescue treatment for patients with severe adult respiratory distress syndrome (ARDS) mainly due to viral causes. In December 2019, several patients presented with a constellation of symptoms of viral pneumonia in China. A new strain of the corona virus family, called COVID-19, has been discovered to be the cause of this severe mysterious illness that was named severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). This new virus continued to spread across the globe leading to the World Health Organization announcing it as a pandemic in the early 2020. By the end of March 2021, the number of COVID-19 cases worldwide exceeded 126 million cases. In Saudi Arabia, the first confirmed case of COVID-19 was reported in the 2nd March 2020. By the end of March 2021, the total number of confirmed COVID-19 cases in Saudi Arabia is just above 360,000. In anticipation of the need of ECMO for the treatment of patients with SARS‑CoV‑2 based on the previous Middle East respiratory syndrome coronavirus pandemic experience, the Saudi Extra-Corporeal Life Support (ECLS) chapter that is under the umbrella of the Saudi Critical Care Society (SCCS) convened a working group of ECMO experts. The mission of this group was to formulate a guidance for the use of ECMO as a last resort for patients with severe ARDS, especially with COVID-19 based on available evidence. The ECLS-SCCS chapter wanted to generate a document that can be used to simple guide, with a focus on safety, to provide ECMO service for patients with severe ARDS with a special focus on SARS‑CoV‑2. 相似文献
107.
108.
Petry Vanessa Bonadio Renata Colombo Cagnacci Allyne Queiroz Carneiro Senna Luiz Antonio Leite Campos Roberta do Nascimento Galvão Cotti Guilherme Cutait Hoff Paulo M. Fragoso Maria Candida Barisson Villares Estevez-Diz Maria del Pilar 《Familial cancer》2020,19(1):47-53
Familial Cancer - The risk of radiotherapy-induced malignancies (RIMs) is a concern when treating Li–Fraumeni syndrome (LFS) or Li–Fraumeni Like (LFL) patients. However, the type of... 相似文献
109.
Wendy Lim Paula Holinski PJ Devereaux Andrea Tkaczyk Ellen McDonald France Clarke Ismael Qushmaq Irene Terrenato Holger Schunemann Mark Crowther Deborah Cook 《Critical care (London, England)》2008,12(2):R36-10
Introduction
To use screening cardiac troponin (cTn) measurements and electrocardiograms (ECGs) to determine the incidence of elevated cTn and of myocardial infarction (MI) in patients admitted to the intensive care unit (ICU), and to assess whether these findings influence prognosis. This is a prospective screening study.Materials and methods
We enrolled consecutive patients admitted to a general medical-surgical ICU over two months. All patients underwent systematic screening with cTn measurements and ECGs on ICU admission, then daily for the first week in ICU, alternate days for up to one month and weekly thereafter until ICU death or discharge, for a maximum of two months. Patients without these investigations ordered during routine clinical care underwent screening for study purposes but these results were unavailable to the ICU team. After the study, all ECGs were interpreted independently in duplicate for ischaemic changes meeting ESC/ACC criteria supporting a diagnosis of MI. Patients were classified as having MI (elevated cTn and ECG evidence supporting diagnosis of MI), elevated cTn only (no ECG evidence supporting diagnosis of MI), or no cTn elevation.Results
One hundred and three patients were admitted to the ICU on 112 occasions. Overall, 37 patients (35.9 per cent) had an MI, 15 patients (14.6 per cent) had an elevated cTn only and 51 patients (49.5 per cent) had no cTn elevation. Patients with MI had longer duration of mechanical ventilation (p < 0.0001), longer ICU stay (p = 0.001), higher ICU mortality (p < 0.0001) and higher hospital mortality (p < 0.0001) compared with those with no cTn elevation. Patients with elevated cTn had higher hospital mortality (p = 0.001) than patients without cTn elevation. Elevated cTn was associated with increased hospital mortality (odds ratio 27.3, 95 per cent CI 1.7 – 449.4), after adjusting for APACHE II score, MI and advanced life support. The ICU team diagnosed 18 patients (17.5 per cent) as having MI on clinical grounds; four of these patients did not have MI by adjudication. Thus, screening detected an additional 23 MIs not diagnosed in practice, reflecting 62.2 per cent of MIs ultimately diagnosed. Patients with MI diagnosed by the ICU team had similar outcomes to patients with MI detected by screening alone.Conclusion
Systematic screening detected elevated cTn measurements and MI in more patients than were found in routine practice. Elevated cTn was an independent predictor of hospital mortality. Further research is needed to evaluate whether screening and subsequent treatment of these patients reduces mortality. 相似文献110.
Won-Seok Lee Ismael Al-Ramahi Hyun-Hwan Jeong Youjin Jang Tao Lin Carolyn J. Adamski Laura A. Lavery Smruti Rath Ronald Richman Vitaliy V. Bondar Elizabeth Alcala Jean-Pierre Revelli Harry T. Orr Zhandong Liu Juan Botas Huda Y. Zoghbi 《The Journal of clinical investigation》2022,132(9)
Many neurodegenerative disorders are caused by abnormal accumulation of misfolded proteins. In spinocerebellar ataxia type 1 (SCA1), accumulation of polyglutamine-expanded (polyQ-expanded) ataxin-1 (ATXN1) causes neuronal toxicity. Lowering total ATXN1, especially the polyQ-expanded form, alleviates disease phenotypes in mice, but the molecular mechanism by which the mutant ATXN1 is specifically modulated is not understood. Here, we identified 22 mutant ATXN1 regulators by performing a cross-species screen of 7787 and 2144 genes in human cells and Drosophila eyes, respectively. Among them, transglutaminase 5 (TG5) preferentially regulated mutant ATXN1 over the WT protein. TG enzymes catalyzed cross-linking of ATXN1 in a polyQ-length–dependent manner, thereby preferentially modulating mutant ATXN1 stability and oligomerization. Perturbing Tg in Drosophila SCA1 models modulated mutant ATXN1 toxicity. Moreover, TG5 was enriched in the nuclei of SCA1-affected neurons and colocalized with nuclear ATXN1 inclusions in brain tissue from patients with SCA1. Our work provides a molecular insight into SCA1 pathogenesis and an opportunity for allele-specific targeting for neurodegenerative disorders. 相似文献