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11.

Comparaison des cinq grands traits de personnalité dans la fibromyalgie et les autres maladies rhumatismales

Emilie Bucourt Virginie Martaillé Denis Mulleman Philippe Goupille Isabelle Joncker-Vannier Brigitte Hüttenberger Christian Reveillere Robert Courtois 《Revue du Rhumatisme》2018,85(2):188-194

相似文献

12.

Prevalence of autoantibodies in the course of Gaucher disease type 1: A multicenter study comparing Gaucher disease patients to healthy subjects

Christine Serratrice Nesma Bensalah Guillaume Penaranda Nathalie Bardin Nadia Belmatoug Agathe Masseau Christian Rose Olivier Lidove Fabrice Camou François Maillot Vanessa Leguy Nadine Magy-Bertrand Isabelle Marie Patrick Cherin Monia Bengherbia Sebastian Carballo José Boucraut Jacques Serratrice Denis Verrot 《Joint, bone, spine : revue du rhumatisme》2018,85(1):71-77

Objectives

Type 1 Gaucher disease may be related to the presence of autoantibodies. Their clinical significance is questioned.Primary endpoint was to compare the prevalence of autoantibodies in type 1 Gaucher disease patients with healthy subjects, seeking correlations with autoimmune characteristics. Secondary endpoints were to determine whether patients with autoantibodies reported autoimmunity-related symptoms and if genotype, splenectomy or treatment influenced autoantibodies presence.

Methods

Type 1 Gaucher disease patients and healthy volunteers were included in this national multicenter exploratory study. Autoantibodies presence was compared in both groups and assessed regarding to genotype, splenectomy, Gaucher disease treatment and autoimmunity-related symptoms.

Results

Twenty healthy subjects and 40 type 1 Gaucher disease patients were included. Of the studied group: 15 patients undergone splenectomy, 37 were treated either with enzyme replacement therapy (34) or with substrate reduction therapy (3), 25 were homozygous/heterozygous for the N370S mutation.In type 1 Gaucher disease group (studied group), 52% had positive autoantibodies versus 26% in control group. Antiphospholipid antibodies were more frequent in the studied group (30% vs. 5%), but without correlation to thrombosis, osteonecrosis or bone infarcts. In the studied group, antinuclear antibodies were more frequent (25% vs. 16%). None of the patients with autoantibodies had clinical manifestations of autoimmune diseases. Autoantibodies were not correlated with treatment, genotype, or splenectomy, except for anticardiolipid, more frequent in splenectomized patients.

Conclusions

In type 1 Gaucher disease, autoantibodies were more frequent compared to a healthy population. However, they were not associated with an increased prevalence of clinical active autoimmune diseases. 相似文献

13.

Ultrasonography and detection of subclinical joints and tendons involvements in Systemic Lupus erythematosus (SLE) patients: A cross-sectional multicenter study

Carine Salliot Amélie Denis Emmanuelle Dernis Vincent Andre Aleth Perdriger Jean-David Albert Saloua Mammou Mraghni Isabelle Griffoul-Espitalier Mohamed Hamidou Benoit Le Goff Sandrine Jousse Joulin Thierry Marhadour Christophe Richez Nicolas Poursac Estebaliz Lazaro Stéphanie Rist Anca Corondan Clara Quinten Emilie Ducourau 《Joint, bone, spine : revue du rhumatisme》2018,85(6):741-745

Objectives

The aims of this study in SLE population were (1) to describe ultrasonography (US) joint abnormalities, (2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, (3) to highlight specific patterns of lupus patients with Power Doppler (PD) abnormalities.

Method

For this cross-sectional multicenter study, 151 consecutive adult SLE patients were recruited. Evaluation included a clinical standardized joint assessment, B-mode and PD US of 40 joints and 26 tendons blinded for clinical examination. Reliability and agreement between clinical and B-mode US were calculated using the intraclass correlation coefficients (ICC [95% Confidence Interval]).

Results

We found a very high frequency of subclinical US abnormalities in asymptomatic patients: 85% of patients without joint symptoms had at least 1 US abnormality. Among them 46 patients (87%) had a history of joint involvement. The most frequent abnormalities were joint effusmaions (108 patients), synovial hypertrophy (SH, 109 patients) and synovitis (61 patients). Joint or tendon PD signal (grade > 1) was found in 44% of patients (67/151). Synovitis were mainly located especially on MCPs and wrists. Even if reliability between clinical and grey-scale US SJC assessments was poor, reliability between clinical and US SLEDAI was good. Comparison between SLE patients with and without PD signal did not show any specific SLE pattern.