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151.
Phillips I 《AIDS patient care and STDs》2002,16(4):147-149
Participating in community wellness projects is one way occupational therapy students at Winston-Salem State University (WSSU), Occupational Therapy Program in North Carolina are learning to expand occupational therapy into the community. In a fieldwork experience, 13 juniors are assigned to a community HIV/AIDS project to increase community awareness and prevention of the spread of HIV/AIDS. The project is implemented in conjunction with HOPE (HIV Outreach Programs and Education), STEP ONE, and the Samaritan Ministries. The students' efforts culminate in an HIV/AIDS Rally. Student learning is grouped into categories of planning, implementation, and follow up. This experience resulted in students working as volunteers for HOPE; students collaborating together on a research project to determine the extent University students understand how to prevent the spread of HIV; and students considering a WSSU campus-based HIV/AIDS awareness activity during October 2001 AIDS Awareness Month. 相似文献
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Rong Liu Stephanie Curry Patricia McMonagle Wendy W. Yeh Steven W. Ludmerer Patricia A. Jumes William L. Marshall Stephanie Kong Paul Ingravallo Stuart Black Irene Pak Mark J. DiNubile Anita Y. M. Howe 《Antimicrobial agents and chemotherapy》2015,59(11):6922-6929
Elbasvir is an investigational NS5A inhibitor with in vitro activity against multiple HCV genotypes. Antiviral activity of elbasvir was measured in replicons derived from wild-type or resistant variants of genotypes 1a, 1b, and 3. The barrier to resistance was assessed by the number of resistant colonies selected by exposure to various elbasvir concentrations. In a phase 1b dose-escalating study, virologic responses were determined in 48 noncirrhotic adult men with chronic genotype 1 or 3 infections randomized to placebo or elbasvir from 5 to 50 mg (genotype 1) or 10 to 100 mg (genotype 3) once daily for 5 days. The NS5A gene was sequenced from plasma specimens obtained before, during, and after treatment. Elbasvir suppressed the emergence of resistance-associated variants (RAVs) in vitro in a dose-dependent manner. Variants selected by exposure to high elbasvir concentrations typically encoded multiple amino acid substitutions (most commonly involving loci 30, 31, and 93), conferring high-level elbasvir resistance. In the monotherapy study, patients with genotype 1b had greater reductions in HCV RNA levels than patients with genotype 1a at all elbasvir doses; responses in patients with genotype 3 were generally less pronounced than for genotype 1, particularly at lower elbasvir doses. M28T, Q30R, L31V, and Y93H in genotype 1a, L31V and Y93H in genotype 1b, and A30K, L31F, and Y93H in genotype 3 were the predominant RAVs selected by elbasvir monotherapy. Virologic findings in patients were consistent with the preclinical observations. NS5A-RAVs emerged most often at amino acid positions 28, 30, 31, and 93 in both the laboratory and clinical trial. (The MK-8742 P002 trial has been registered at ClinicalTrials.gov under identifier .) NCT01532973相似文献
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Georgia R. Gore‐Langton Matthew Cairns Yves Daniel Compaor Issaka Sagara Irene Kuepfer Issaka Zongo Mariken M. de Wit Amadou Barry Modibo Diarra Amadou Tapily Samba Coumare Ismail Thera Frederic Nikiema R. Serge Yerbanga Rosemonde M. Guissou Halidou Tinto Alassane Dicko Daniel Chandramohan Brian Greenwood Jean Bosco Ouedraogo 《Tropical medicine & international health : TM & IH》2020,25(6):740-750
158.
Irene G. M. Van Valkengoed PhD Liffert Vogt MD PhD Bert‐Jan H. Van Den Born MD PhD 《Journal of clinical hypertension (Greenwich, Conn.)》2014,16(2):122-126
The survival of patients with malignant hypertension (MHT) has considerably improved over the past decades. Data regarding the excess risk of mortality and the contribution of conventional cardiovascular risk factors are lacking. The authors retrospectively assessed cardiovascular risk factors and all‐cause mortality in 120 patients with a history of MHT and compared them with 120 normotensive and 120 hypertensive age‐, sex‐, and ethnicity‐matched controls. Total cholesterol, low‐density lipoprotein cholesterol, and body mass index were lower in MHT patients compared with hypertensive controls, whereas blood pressure, high‐density lipoprotein cholesterol, and smoking habit were similar. Median estimated glomerular filtration rate was lower in MHT patients compared with normotensive and hypertensive controls (both P<.01). The annual incidence of all‐cause mortality per 100 patient‐years was higher in MHT patients (2.6) compared with normotensive (0.2) and hypertensive (0.5) controls (both P<.01). Mortality of patients with a history of MHT remains high compared with normotensive and hypertensive controls. Patients with MHT had a more favorable cardiovascular risk profile compared with hypertensive controls but a higher prevalence of renal insufficiency. 相似文献
159.
Tilman T. Rau Abbas Agaimy Anastasia Gehoff Carol Geppert Klaus Jung Katharina Knobloch Cord Langner Alessandro Lugli Irene Groenbus-Lurkin Iris D. Nagtegaal Josef Rüschoff Xavier Saegert Mario Sarbia Regine Schneider-Stock Michael Vieth Ellen C. Zwarthoff Arndt Hartmann 《Virchows Archiv : an international journal of pathology》2014,464(6):663-672
Criteria for the diagnosis of serrated colorectal lesions (hyperplastic polyp, sessile serrated adenoma without or with dysplasia—which we called mixed polyp—and traditional serrated adenoma) for which consensus has been reached should be validated for applicability in daily practice in terms of inter-observer reproducibility and their association with clinical features and (epi)genetic events. A study set was created from a consecutive series of colorectal polyps (n?=?1,926) by selecting all sessile serrated adenomas, traditional serrated adenomas and mixed polyps. We added consecutive series of hyperplastic polyps, classical adenomas and normal mucosa samples for a total of 200 specimens. With this series, we conducted an inter-observer study, encompassing ten pathologists with gastrointestinal pathology experience from five European countries, in three rounds in which all cases were microscopically evaluated. An assessment of single morphological criteria was included, and these were correlated with clinical parameters and the mutation status of KRAS, BRAF and PIK3CA and the methylation status of MLH1. Gender, age and localisation were significantly associated with certain types of lesions. Kappa statistics revealed moderate to good inter-observer agreement for polyp classification (κ = 0.56 to 0.63), but for single criteria, this varied considerably (κ = 0.06 to 0.82). BRAF mutations were frequently found in hyperplastic polyps (86 %, 62/72) and sessile serrated adenomas (80 %, 41/51). KRAS mutations occurred more frequently in traditional serrated adenomas (78 %, 7/9) and less so in classical adenomas (20 %, 10/51). Single morphological criteria for sessile serrated adenomas showed significant correlation with BRAF mutation (all p?≤?0.001), and those for classical adenomas or traditional serrated adenoma correlated significantly with KRAS mutation (all p?<?0.001). Therefore, single well-defined morphological criteria are predictive for genetic alterations in colorectal polyps. 相似文献
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