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排序方式: 共有2057条查询结果,搜索用时 18 毫秒
991.
Mohammad Akram Hossain Isao Hamamoto Shoji Kobayashi Takashi Maeba Hajime Maeta 《Journal of hepato-biliary-pancreatic sciences》1998,5(4):437-444
The effects of intraportal administration of prostaglandin E1 (PGE1) on portal venous flow, hepatic arterial flow, peripheral tissue blood flow, and systemic arterial flow before and after 60 min total liver ischemia followed by 70% partial hepatectomy in rats were investigated. Total liver ischemia was induced by occluding the hepatoduodenal ligament for 60 min. PGE1 at a dose of 0.5 μg/kg/min was infused intraportally for 15 min before inducing hepatic ischemia (preischemic period) and for 60 min after ischemia (postischemic reperfusion period) in the treatment group. Normal saline was infused in the control group. Seventy percent partial hepatectomy was performed during ischemia. Serum biochemical analysis and liver tissue histology were carried out 1, 3, and 24 h, and 1 and 24 h after reperfusion respectively. One-week survival of the PGE1 group was improved to 70% compared to that of the control group of 30%. Postischemia reperfusion values of portal and peripheral tissue blood flows in the PGE1 group were 6.33 ± 0.600 ml/min and 27.2 ± 23.5 (arbitrary), and were significantly different from those of the control group of 4.34 ± 0.400 ml/min and 23.5 ± 5.54 (arbitrary), respectively. There was no significant difference in hepatic arterial flow between the two groups. Serum alkaline phosphatase decreased significantly in the prostaglandin group. Histological examination revealed a significant portal venous congestion in the control group 1 and 24 h after reperfusion. The extent of the sinusoidal congestion was also severe in the control group 24 h after reperfusion. It was concluded that PGE1 has a protective effect against liver damage when the liver was injured by warm ischemia and reperfusion followed by partial resection. 相似文献
992.
Performance of variations of carbolfuchsin staining of sputum smears for AFB under field conditions.
A Van Deun A Hamid Salim K J M Aung Md A Hossain N Chambugonj Md A Hye A Kawria E Declercq 《The international journal of tuberculosis and lung disease》2005,9(10):1127-1133
SETTING: A field project in Bangladesh. OBJECTIVE: To compare the effectiveness of commonly used carbolfuchsin staining variations. DESIGN: Routine hot Ziehl-Neelsen (ZN) 1% basic fuchsin staining for 15 min in 75 field clinics. Blind reading of duplicate smears stained by ZN 1% vs. 0.3% basic fuchsin applied for 5 min, or by ZN 1% 5 min vs. Kinyoun cold staining. Rechecking of discordant series. RESULTS: For comparable numbers of false positives, sensitivity was significantly lower with Kinyoun than with ZN 1% 5 min (85.6% vs. 93.0%, P < 0.001). Sensitivity with ZN 1% 5 min was not significantly higher than with 0.3% 5 min staining (89.9% vs. 86.5%). Routine examination using 1% 15 min ZN identified more positives than any of the study techniques. CONCLUSIONS: Kinyoun cold staining sensitivity was unsatisfactory in field clinics. The sensitivity of the WHO/IUATLD recommended 0.3% fuchsin for 5 min was not significantly different from the original 1% ZN for 5 min, but 1% 15 min hot staining might be superior. A reduced fuchsin concentration together with a short staining time may leave too narrow a margin for error. TB programmes using hot ZN with a concentrated stain or longer staining time should not be urged to change. 相似文献
993.
994.
Hind A. Beydoun Catherine Butt May A. Beydoun Sharmin Hossain Shaker M. Eid Alan B. Zonderman 《Medicine》2021,100(6)
Despite its public health significance, TBI management across US healthcare institutions and patient characteristics with an emphasis on utilization and outcomes of TBI-specific procedures have not been evaluated at the national level.We aimed to characterize top 10 procedure codes among hospitalized adults with TBI as primary diagnosis by injury severity.A Cross-sectional study was conducted using 546, 548 hospitalization records from the 2004 to 2014 Nationwide Inpatient Sample were analyzed.Data elements of interest included injury, patient, hospital characteristics, procedures, in-hospital death and length of stay.Ten top procedure codes were “Closure of skin and subcutaneous tissue of other sites”, “Insertion of endotracheal tube”, “Continuous invasive mechanical ventilation for less than 96 consecutive hours”, “Venous catheterization (not elsewhere classified)”, “Continuous invasive mechanical ventilation for 96 consecutive hours or more”, “Transfusion of packed cells”, “Incision of cerebral meninges”, “Serum transfusion (not elsewhere classified)”, “Temporary tracheostomy”, and “Arterial catherization”. Prevalence rates ranged between 3.1% and 15.5%, with variations according to injury severity and over time. Whereas “Closure of skin and subcutaneous tissue of other sites” was associated with fewer in-hospital deaths and shorter hospitalizations, “Temporary tracheostomy” was associated with fewer in-hospital deaths among moderate-to-severe TBI patients, and “Continuous invasive mechanical ventilation for less than 96 consecutive hours” was associated with shorter hospitalizations among severe TBI patients. Other procedures were associated with worse outcomes.Nationwide, the most frequently reported hospitalization procedure codes among TBI patients aimed at homeostatic stabilization and differed in prevalence, trends, and outcomes according to injury severity. 相似文献
995.
Lazarus Matthew S. Hossain Rydhwana Villasana Geraldine M. Herring Allison A. Ye Kenny Jeudy Jean Levsky Jeffrey M. White Charles S. Haramati Linda B. 《Lung》2022,200(4):441-445
Lung - Prone position is known to improve acute lung injury, and chest radiographs are often necessary to monitor disease and confirm support device placement. However, there is a paucity of... 相似文献
996.
Sushil Kumar Bin Lu Updesh Dixit Sajjad Hossain Yongzhang Liu Jing Li Peter Hornbeck Weiming Zheng Adam G. Sowalsky Leszek Kotula Raymond B. Birge 《Oncotarget》2015,6(35):37792-37807
Crk is the prototypical member of a class of Src homology 2 (SH2) and Src homology 3 (SH3) domain-containing adaptor proteins that positively regulate cell motility via the activation of Rac1 and, in certain tumor types such as GBM, can promote cell invasion and metastasis by mechanisms that are not well understood. Here we demonstrate that Crk, via its phosphorylation at Tyr251, promotes invasive behavior of tumor cells, is a prominent feature in GBM, and correlating with aggressive glioma grade IV staging and overall poor survival outcomes. At the molecular level, Tyr251 phosphorylation of Crk is negatively regulated by Abi1, which competes for Crk binding to Abl and attenuates Abl transactivation. Together, these results show that Crk and Abi1 have reciprocal biological effects and act as a molecular rheostat to control Abl activation and cell invasion. Finally, these data suggest that Crk Tyr251 phosphorylation regulate invasive cell phenotypes and may serve as a biomarker for aggressive GBM. 相似文献
997.
998.
Nazmul Haque Md. Towhidul Islam M. M. Tariqul Hassan Md. Shekhar Hossain Uddin 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(2):543-549
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - In Bangladesh, the poultry products are now severely contaminated with toxic heavy metals from different... 相似文献
999.
Preya Janubhai Patel Fabrina Hossain Leigh Ula Horsfall Xuan Banh Kelly Lee Hayward Suzanne Williams Tracey Johnson Nigel Neil Brown Nivene Saad Patricia Casarolli Valery Katharine Margaret Irvine Andrew Donald Clouston Katherine Anne Stuart Anthony William Russell Elizabeth Ellen Powell 《Journal of diabetes and its complications》2018,32(8):799-804
Aims
To examine the relationship between steatosis quantified by controlled attenuation parameter (CAP) values and glycaemic/metabolic control.Methods
230 patients, recruited from an Endocrine clinic or primary care underwent routine Hepatology assessment, with liver stiffness measurements and simultaneous CAP. Multivariable logistic regression was performed to identify potential predictors of Metabolic Syndrome (MetS), HbA1c?≥?7%, use of insulin, hypertriglyceridaemia and CAP?≥?300?dB/m.Results
Patients were 56.7?±?12.3?years of age with a high prevalence of MetS (83.5%), T2DM (81.3%), and BMI?≥?40?kg/m2 (18%). Median CAP score was 344?dB/m, ranging from 128 to 400?dB/m. BMI (aOR 1.140 95% CI 1.068–1.216), requirement for insulin (aOR 2.599 95% CI 1.212–5.575), and serum ALT (aOR 1.018 95% CI 1.004–1.033) were independently associated with CAP?≥?300?dB/m. Patients with CAP interquartile range?<?40 (68%) had a higher median serum ALT level (p?=?0.029), greater prevalence of BMI?≥?40?kg/m2 (p?=?0.020) and higher median CAP score (p?<?0.001). Patients with higher CAP scores were more likely to have MetS (aOR 1.011 95% CI 1.003–1.019), HBA1c?≥?7 (aOR 1.010 95% CI 1.003–1.016), requirement for insulin (aOR 1.007 95% CI 1.002–1.013) and hypertriglyceridemia (aOR 1.007 95% CI 1.002–1.013).Conclusions
Our data demonstrate that an elevated CAP reflects suboptimal metabolic control. In diabetic patients with NAFLD, CAP may be a useful point-of-care test to identify patients at risk of poorly controlled metabolic comorbidities or advanced diabetes. 相似文献1000.
Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine. 总被引:2,自引:0,他引:2
Sierra Matula Victoria Croog Steven Itzkowitz Noam Harpaz Carol Bodian Sabera Hossain Thomas Ullman 《Clinical gastroenterology and hepatology》2005,3(10):1015-1021
BACKGROUND & AIMS: Evidence suggests that mesalamine-based anti-inflammatory medicines may prevent colorectal cancer (CRC) in ulcerative colitis (UC). If mesalamine exerts its chemopreventive effect by its anti-inflammatory activity, then other medications that reduce colitis activity also should possess chemopreventive properties. Our aim was to determine the effect of the immunomodulators 6-mercaptopurine (6MP) and azathioprine (AZA) in preventing the development of dysplasia or CRC in UC. METHODS: Patients with UC who underwent a surveillance colonoscopy in 1996-1997 were identified from a gastrointestinal pathology database. A proportional hazards analysis assessing 6MP/AZA use as a time-changing covariate was performed to evaluate the effect of 6MP/AZA on: (1) progression to any neoplasia (low-grade dysplasia, high-grade dysplasia, or CRC), and (2) progression to advanced neoplasia (high-grade dysplasia or CRC). RESULTS: A total of 315 subjects met inclusion criteria and were followed for an average of 8 years from their first surveillance examination. There were no significant differences in rates of progression to advanced neoplasia or to any neoplasia between 6MP/AZA users and never-users by log-rank testing. The proportional hazards analysis resulted in hazard ratios of 1.06 (95% confidence interval, .59-1.93) and 1.30 (95% confidence interval, .45-3.75) when considering the effect of exposure to 6MP/AZA on progression to any or to advanced neoplasia, respectively. The results were unaffected by known potential confounders. CONCLUSIONS: In UC patients with no initial history of dysplasia, 6MP/AZA use appears to have little or no effect on the rate of neoplastic transformation in the colon. Importantly, the use of 6MP/AZA did not increase malignant transformation in UC. 相似文献