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排序方式: 共有526条查询结果,搜索用时 15 毫秒
521.
Ashika D. Maharaj Liane Ioannou Daniel Croagh John Zalcberg Rachel E. Neale David Goldstein Neil Merrett James G. Kench Kate White Charles H.C. Pilgrim Lorraine Chantrill Peter Cosman Andrew Kneebone Lara Lipton Mehrdad Nikfarjam Jennifer Philip Charbel Sandroussi Peter Tagkalidis Sue M. Evans 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2019,21(4):444-455
Background
Best practise care optimises survival and quality of life in patients with pancreatic cancer (PC), but there is evidence of variability in management and suboptimal care for some patients. Monitoring practise is necessary to underpin improvement initiatives. We aimed to develop a core set of quality indicators that measure quality of care across the disease trajectory.Methods
A modified, three-round Delphi survey was performed among experts with wide experience in PC care across three states in Australia. A total of 107 potential quality indicators were identified from the literature and divided into five areas: diagnosis and staging, surgery, other treatment, patient management and outcomes. A further six indicators were added by the panel, increasing potential quality indicators to 113. Rated on a scale of 1–9, indicators with high median importance and feasibility (score 7–9) and low disagreement (<1) were considered in the candidate set.Results
From 113 potential quality indicators, 34 indicators met the inclusion criteria and 27 (7 diagnosis and staging, 5 surgical, 4 other treatment, 5 patient management, 6 outcome) were included in the final set.Conclusions
The developed indicator set can be applied as a tool for internal quality improvement, comparative quality reporting, public reporting and research in PC care. 相似文献522.
K Sazama ; IK Kuramoto ; PV Holland ; AM Courouce ; D Gallo ; CV Hanson 《Transfusion》1992,32(5):398-401
Twelve serum samples from French blood donors that were uniformly reactive in tests for antibody to human immunodeficiency virus type 2 (anti-HIV-2) also were reactive in 92 to 100 percent of tests with three anti-HIV type 1 (anti-HIV-1) enzyme-linked immunoassays currently in widespread use for donor screening in the United States. Supplemental tests for anti-HIV-1 on these anti-HIV-2-reactive samples differed in their responses. All samples reacted in a licensed anti-HIV-1 Western blot, but there was an atypical band near the p41 position, which could be a clue to the fact that this result was a cross-reaction with anti-HIV-2. A recombinant immunoblot gave an indeterminate result for anti-HIV-1 in all 12 samples. A local immunofluorescence assay for anti-HIV-1 reacted with 92 percent of the samples, but a commercial one detected only 58 percent. 相似文献
523.
Heterozygous mutations of the KCNJ11 gene encoding the Kir6.2 subunit of the ATP-sensitive potassium channel (K(ATP) channel) of the pancreatic β-cell cause diabetes in about 30-60% of all permanent neonatal diabetes mellitus cases diagnosed before 6 months of age. The K(ATP) channel plays an essential role in the regulation of the electrical status of the membrane through which the secretion of insulin is activated. Transient neonatal diabetes mellitus due to KCNJ11 mutations is less frequent than abnormalities affecting the imprinted region of chromosome 6q24. We studied the genetic basis of two Cypriot patients who developed diabetes before 6 months of age. They both carried mutations of the KCNJ11 gene. The R201H mutation was identified in a patient who developed hyperglycemia and ketoacidosis at the age of 40 d and was successfully transferred to sulphonylureas which activate the channel through an ATP independent route. The R50Q mutation was identified in a child diagnosed at day 45 after birth with remission of his diabetes at 9 months of age. The same defect was identified both in his asymptomatic mother and the recently diagnosed 'type 2' diabetic maternal grandmother. The remission-relapse mechanism in cases of transient neonatal diabetes is not known. Nevertheless, it is possible that the residue of the mutation within the Kir6.2 molecule is associated with the sensitivity to ATP reflecting to the severity of the diabetic phenotype. 相似文献
524.
N. M. Millan P. Lau M. Hann D. Ioannou D. Hoffman M. Barrionuevo W. Maxson S. Ory H. G. Tempest 《Chromosome research》2012,20(7):875-887
It is well established that chromosomes occupy distinct positions within the interphase nuclei, conferring a potential functional implication to the genome. In addition, alterations in the nuclear organisation patterns have been associated with disease phenotypes (e.g. cancer or laminopathies). The human sperm is the smallest cell in the body with specific DNA packaging and the mission of delivering the paternal genome to the oocyte during fertilisation. Studies of nuclear organisation in the sperm have postulated nonrandom chromosome position and have proposed a chromocentre model with the centromeres facing toward the interior and the telomeres toward the periphery of the nucleus. Most studies have assessed the nuclear address in the sperm longitudinally predominantly using centromeric or telomeric probes and to a lesser extent with whole chromosome paints. To date, studies investigating the radial organisation of human sperm have been limited. The purpose of this study was to utilise whole chromosome paints for six clinically important chromosomes (18, 19, 21, 22, X, and Y) to investigate nuclear address by assessing their radial and longitudinal nuclear organisation. A total of 10,800 sperm were analysed in nine normozoospermic individuals. The results have shown nonrandom chromosome position for all chromosomes using both methods of analysis. We present novel radial and polar analysis of chromosome territory localization within the human sperm nucleus. Specifically, a hierarchical organisation was observed radially with chromosomes organised from the interior to the periphery (chromosomes 22, 21, Y, X, 19, and 18 respectively) and polar organisation from the sperm head to tail (chromosomes X, 19, Y, 22, 21, and 18, respectively). We provide evidence of defined nuclear organisation in the human sperm and discuss the function of organisation and potential possible clinical ramifications of these results in regards to male infertility and early human development. 相似文献
525.
Kartika Padhan Eirini Moysi Alessandra Noto Alexander Chassiakos Khader Ghneim Maria Maddalena Perra Sanjana Shah Vasilis Papaioannou Giulia Fabozzi David R. Ambrozak Antigoni Poultsidi Maria Ioannou Craig Fenwick Samuel Darko Daniel C. Douek Rafick-Pierre Sekaly Giuseppe Pantaleo Richard A. Koup Constantinos Petrovas 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(18)
526.
E. H. S. Choy D. A. Isenberg T. Garrood S. Farrow Y. Ioannou H. Bird N. Cheung B. Williams B. Hazleman R. Price K. Yoshizaki N. Nishimoto T. Kishimoto G. S. Panayi 《Arthritis \u0026amp; Rheumatology》2002,46(12):3143-3150