全文获取类型
收费全文 | 15628篇 |
免费 | 909篇 |
国内免费 | 201篇 |
专业分类
耳鼻咽喉 | 285篇 |
儿科学 | 409篇 |
妇产科学 | 362篇 |
基础医学 | 2231篇 |
口腔科学 | 445篇 |
临床医学 | 1386篇 |
内科学 | 3228篇 |
皮肤病学 | 325篇 |
神经病学 | 1128篇 |
特种医学 | 1029篇 |
外科学 | 1947篇 |
综合类 | 200篇 |
一般理论 | 1篇 |
预防医学 | 838篇 |
眼科学 | 449篇 |
药学 | 1257篇 |
2篇 | |
中国医学 | 169篇 |
肿瘤学 | 1047篇 |
出版年
2023年 | 102篇 |
2022年 | 252篇 |
2021年 | 476篇 |
2020年 | 216篇 |
2019年 | 344篇 |
2018年 | 462篇 |
2017年 | 323篇 |
2016年 | 413篇 |
2015年 | 612篇 |
2014年 | 687篇 |
2013年 | 911篇 |
2012年 | 1311篇 |
2011年 | 1237篇 |
2010年 | 757篇 |
2009年 | 643篇 |
2008年 | 847篇 |
2007年 | 814篇 |
2006年 | 763篇 |
2005年 | 670篇 |
2004年 | 576篇 |
2003年 | 474篇 |
2002年 | 434篇 |
2001年 | 404篇 |
2000年 | 348篇 |
1999年 | 263篇 |
1998年 | 213篇 |
1997年 | 204篇 |
1996年 | 168篇 |
1995年 | 154篇 |
1994年 | 155篇 |
1993年 | 136篇 |
1992年 | 142篇 |
1991年 | 123篇 |
1990年 | 120篇 |
1989年 | 141篇 |
1988年 | 117篇 |
1987年 | 103篇 |
1986年 | 100篇 |
1985年 | 94篇 |
1984年 | 55篇 |
1983年 | 43篇 |
1982年 | 44篇 |
1981年 | 39篇 |
1980年 | 38篇 |
1979年 | 17篇 |
1978年 | 24篇 |
1977年 | 31篇 |
1976年 | 36篇 |
1975年 | 28篇 |
1974年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
Andres A; Morales JM; Praga M; Campo C; Lahera V; Garcia-Robles R; Rodicio JL; Ruilope LM 《Nephrology, dialysis, transplantation》1997,12(7):1437-1440
BACKGROUND: Cyclosporin has been shown to facilitate renal vasoconstriction
and to have an antinatriuretic effect. The existence of an interference of
cyclosporin with the vasodilating properties of endothelium mediated by
nitric oxide production could mediate these effects. On the other hand, the
infusion of the nitric oxide precursor L-arginine has been shown to induce
renal vasodilatation and to facilitate natriuresis in normal volunteers. We
have investigated the renal effects of the administration of an infusion of
L-arginine in renal transplant patients chronically treated with
cyclosporin. To facilitate the analysis of the data the effects of the
administration of a similar dose of cyclosporin on renal function during
the infusion of a vehicle were also investigated during the administration
of a vehicle of L-arginine. DESIGN: Ten male renal transplant patients,
chronically treated with cyclosporin and with a stable renal function were
studied during 2 consecutive days after the administration of the usual
morning dose of cyclosporin. The first day they received an intravenous
infusion of vehicle and the second the infusion of graded doses of
L-arginine (50, 100, 150 mg/kg/h) during 3 consecutive h. RESULTS: The
first day, after cyclosporin administration a significant fall (P <
0.01) was observed in natriuresis and kaliuresis in the absence of changes
in renal plasma flow and glomerular filtration rate. After the
administration of L-arginine significant (P < 0.01) increases of renal
plasma flow, glomerular filtration rate, and natriuresis were seen. The
increase in blood levels of cyclosporin after its administration did not
differ between days 1 and 2. CONCLUSION: These results indicate that
L-arginine facilitates renal vasodilatation and natriuresis in renal
transplant patients. Furthermore, the observed increase in sodium excretion
could indicate that L-arginine counteracts the antinatriuretic effect of
cyclosporin.
相似文献
52.
53.
54.
Jia-You Fang Yann-Lii Leu Tsong-Long Hwang Hsiao-Chin Cheng Chi-Feng Hung 《European journal of pharmaceutical sciences》2003,19(4):253-262
To improve the drug permeation into and/or across the skin, essential oils extracted from Alpinia oxyphylla (AO) were evaluated using in vitro and in vivo permeation techniques with Wistar rats as the animal model. Hydrocarbons and oxygenated sesquiterpenes were the major components in the lower-polarity fraction (AO-1) and higher-polarity fraction (AO-2), respectively. Permeation of indomethacin was significantly enhanced after treatment with AO-1 and AO-2 in the in vitro and in vivo studies. AO-2 generally showed a higher ability to promote drug permeation compared to AO-1. The increment of skin/vehicle partitioning may be the predominant mechanism for this enhancing activity. Both transepidermal water loss (TEWL) and colorimetric evaluation showed limited irritation to skin by AO essential oils at the macroscopic level. Human skin fibroblasts were used to investigate the in vitro screening of skin toxicity. AO-1 slightly increased prostaglandin E(2) (PGE(2)) formation from skin fibroblasts. A striking result was observed with AO-2, which greatly inhibited the release of PGE(2). Moreover, both AO essential oils had no statistically significant effect on PGE(2) release by human lung epithelial cells. The results of this study indicate that skin disruption and inflammation do not necessary correspond to the enhancing efficiency of the enhancers tested. 相似文献
55.
Variants of B cell lymphoma 6 (BCL6) and marked atopy 总被引:3,自引:0,他引:3
Chaker N Adra PS Gao XQ Mao Beverly W Baron S. Pauker T. Miki T. Shirakawa JM Hopkin 《Clinical genetics》1998,54(4):362-364
56.
57.
Meniscal abnormalities: prospective correlation of double-contrast arthrography and arthroscopy 总被引:2,自引:0,他引:2
In a prospective study conducted over a 12-month period, 30 patients underwent double-contrast arthrography of the knee followed by arthroscopic study. An 80% correlation rate was found between results. Arthrography had a higher rate of accuracy (93%) than arthroscopy (84%) and had a 7% false-positive and 0% false-negative rate. A commonly overlooked arthrographic sign--the triple-S or stuck sail sign--was 91% accurate in the prediction of meniscal tears. The complementary nature of the two examinations is discussed. 相似文献
58.
Intrapericardial teratoma. Ultrasonic and pathological features 总被引:1,自引:0,他引:1
59.
60.