有机药物化学中不对称合成手性产率及其随温度变化规律的研究

本文首次用分子力学计算产物或过渡态分子内张力能来估算热力学或动力学,控制不对称合成反应生成的立体异构体的相对比例,并从热力学上推导了这一比例随温度变化公式,而且从实验上得到证明,在有机或药物化学最富有挑战性的领域——不对称合成中具有重要的理论和实际意义。     

成人高原心脏病临床分型的探讨

本文总结了６８０例成人高原心脏病临床资料，依照其临床表现、Ｘ线、心电图等项检查，提出了临床上较为实用的诊断和分型意见。     

粮谷尘致肺损害的实验研究

粮谷尘为混合性粉尘，含游离ＳｉＯ２９．７７％，分离培养出普通高温放线菌。染尘动物肺脏早期病变主要为小灶性肺泡炎、灶性间质性肺炎、异物肉芽肿等，大、中支气管壁脱颗粒肥大细胞增多。９０ｄ以后，上述病变明显减少，但逐渐出现少数小的细胞结节，间质轻度纤维组织增生、支气管慢性炎症和小叶中央型肺气肿样病变，观察１ａ（年）未见明显纤维化。     

微波等离子体化学气相沉积合成TiN超细颗粒

热力学计算表明，Ｈ２，Ｎ２的过量有助于提高ＴｉＮ的产率，但能耗也相应增加。为此考察了温度，流量，ＴｉＣｌ４携带量，混合方式对产物性能的影响。结果表明，流量增加，温度升高，ＴｉＣｌ４携带量增加，混合愈好，则产物粒径愈小。在此基础上采用微波等离子体化学气相沉积法，合成了粒径为１２３－２８４ｎｍ的ＴｉＮ超细颗粒     

The fit of fixed partial dentures joined by infrared soldering.

This study determined the accuracy of fit of three-unit fixed partial dentures joined by an infrared soldering technique compared with one-piece fixed partial denture castings and individually cast crowns. Wax patterns of prepared Ivorine teeth, maxillary left central incisor and maxillary left canine, were injection molded; a plastic rod was used as a pontic. One group of patterns was cast as one-piece dentures; the other group was sectioned in the connector area, cast individually and then joined by infrared soldering. Castings were seated on their respective dies, embedded in epoxy resin, and sectioned. Gap distances between the casting and the die were measured at specified marginal sites with a profile projector. Results showed that the fit of infrared-soldered fixed partial dentures was significantly better than that of one-piece castings and was comparable with the fit of single crowns. The gap openings measured in all castings were within the range of clinical acceptability.     

近年中医药治疗中风后遗症进展

中医药对中风后遗症治疗方法主要包括：①辨证分型治疗；②主方加减治疗，具体包括补气活血方、滋补肝肾方和健脾益气方；③虫类药治疗；④单味药治疗。但是，今后应把中医药、针灸、推拿等方法综合应用于临床，以便取得更好的疗效。同时应加强临床科研设计和实验研究，使中医药治疗中风后遗症更上一个层次。     

In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules.

Alginates are the most employed biomaterials for cell encapsulation due to their abundance, easy gelling properties and apparent biocompatibility. However, as natural polymers different impurities including endotoxins, proteins and polyphenols can be found in their composition. Several purification protocols as well as different batteries of assays to prove the biocompatibility of the alginates in vitro have been recently developed. However, little is known about how the use of alginates with different purity grade may affect the host immune response after their implantation in vivo. The present paper investigates the long-term functionality and biocompatibility of murine erythropoietin (EPO) secreting C2C12 cells entrapped in microcapsules elaborated with alginates with different properties (purity, composition and viscosity). Results showed that independently of the alginate type employed, the animals presented elevated hematocrit levels until day 130, remaining at values between 70-87%. However, histological analysis of the explanted devices showed higher overgrowth around non-biomedical grade alginate microcapsules which could be directly related with higher impurity content of this type of alginate. Although EPO delivery may be limited by the formation of a fibrotic layer around non-biomedical grade alginate microcapsules, the high EPO secretion of the encapsulated cells together with the pharmacodynamic behaviour and the angiogenic and immune-modulatory properties of EPO result in no direct correlation between the biocompatibility of the alginate and the therapeutic response obtained.     

膝前框形钢丝内固定治疗髌骨骨折

目的　总结采用钢丝环扎 +膝前方框形张力带钢丝内固定法治疗髌骨骨折的经验和临床效果。方法　对 3 5例髌骨骨折应用此方法治疗 ,其中男性 2 4例 ,女性 11例 ,3 0例获得 3～ 2 4个月随访。结果　优 19例 ,良 10例 ,可1例 ,优良率 96 7%。术后未出现骨折再移位 ,无伤口感染。愈合时间 6～ 12周。结论　该方法符合生物力学原理 ,操作简便 ,适应证广 ,能早期关节活动 ,是治疗髌骨骨折的理想方法之一。     

Ca^＋＋对链霉素抗原—抗体反应的抑制作用

为探讨临床中使用钙制剂抢救链霉素过敏休克病人有良好效果的原因,由被动血凝试验、被动皮肤过敏试验和ELISA法证实,Ca~( )可以抑制链霉素抗原-抗体的反应。这种抑制作用是通过Ca~( )链霉素抗原结合,封闭链霉素抗原决定簇来加以实现的。