全文获取类型
收费全文 | 2301篇 |
免费 | 124篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 170篇 |
儿科学 | 40篇 |
妇产科学 | 244篇 |
基础医学 | 238篇 |
口腔科学 | 57篇 |
临床医学 | 198篇 |
内科学 | 353篇 |
皮肤病学 | 13篇 |
神经病学 | 105篇 |
特种医学 | 224篇 |
外科学 | 280篇 |
综合类 | 56篇 |
一般理论 | 1篇 |
预防医学 | 202篇 |
眼科学 | 52篇 |
药学 | 141篇 |
中国医学 | 2篇 |
肿瘤学 | 88篇 |
出版年
2021年 | 21篇 |
2019年 | 27篇 |
2018年 | 33篇 |
2017年 | 20篇 |
2016年 | 21篇 |
2015年 | 28篇 |
2014年 | 49篇 |
2013年 | 47篇 |
2012年 | 65篇 |
2011年 | 73篇 |
2010年 | 55篇 |
2009年 | 67篇 |
2008年 | 64篇 |
2007年 | 82篇 |
2006年 | 63篇 |
2005年 | 68篇 |
2004年 | 65篇 |
2003年 | 63篇 |
2002年 | 57篇 |
2001年 | 55篇 |
2000年 | 52篇 |
1999年 | 67篇 |
1998年 | 78篇 |
1997年 | 68篇 |
1996年 | 63篇 |
1995年 | 44篇 |
1994年 | 42篇 |
1993年 | 55篇 |
1992年 | 49篇 |
1991年 | 54篇 |
1990年 | 51篇 |
1989年 | 66篇 |
1988年 | 62篇 |
1987年 | 70篇 |
1986年 | 40篇 |
1985年 | 57篇 |
1984年 | 40篇 |
1983年 | 37篇 |
1982年 | 25篇 |
1981年 | 39篇 |
1980年 | 34篇 |
1979年 | 30篇 |
1978年 | 28篇 |
1977年 | 24篇 |
1976年 | 25篇 |
1975年 | 23篇 |
1974年 | 25篇 |
1973年 | 29篇 |
1970年 | 24篇 |
1969年 | 22篇 |
排序方式: 共有2464条查询结果,搜索用时 46 毫秒
101.
Catharina Carolina de Jong Wynand JG Ros Guus Schrijvers 《Journal of medical Internet research》2014,16(1)
Background
In support of professional practice, asynchronous communication between the patient and the provider is implemented separately or in combination with Internet-based self-management interventions. This interaction occurs primarily through electronic messaging or discussion boards. There is little evidence as to whether it is a useful tool for chronically ill patients to support their self-management and increase the effectiveness of interventions.Objective
The aim of our study was to review the use and usability of patient-provider asynchronous communication for chronically ill patients and the effects of such communication on health behavior, health outcomes, and patient satisfaction.Methods
A literature search was performed using PubMed and Embase. The quality of the articles was appraised according to the National Institute for Health and Clinical Excellence (NICE) criteria. The use and usability of the asynchronous communication was analyzed by examining the frequency of use and the number of users of the interventions with asynchronous communication, as well as of separate electronic messaging. The effectiveness of asynchronous communication was analyzed by examining effects on health behavior, health outcomes, and patient satisfaction.Results
Patients’ knowledge concerning their chronic condition increased and they seemed to appreciate being able to communicate asynchronously with their providers. They not only had specific questions but also wanted to communicate about feeling ill. A decrease in visits to the physician was shown in two studies (P=.07, P=.07). Increases in self-management/self-efficacy for patients with back pain, dyspnea, and heart failure were found. Positive health outcomes were shown in 12 studies, where the clinical outcomes for diabetic patients (HbA1c level) and for asthmatic patients (forced expiratory volume [FEV]) improved. Physical symptoms improved in five studies. Five studies generated a variety of positive psychosocial outcomes.Conclusions
The effect of asynchronous communication is not shown unequivocally in these studies. Patients seem to be interested in using email. Patients are willing to participate and are taking the initiative to discuss health issues with their providers. Additional testing of the effects of asynchronous communication on self-management in chronically ill patients is needed. 相似文献102.
Berenice H. G. Lim Richie Soong Fabienne Grieu Peter D. Robbins Anthony K. House Barry J. Iacopetta 《International journal of cancer. Journal international du cancer》1996,69(3):200-204
The aim of our study was to examine the prognostic significance of p53 protein accumulation and gene mutation in a series of 116 gastric carcinomas from a low incidence population. Formalin-fixed, paraffin-embedded tumour sections were used to investigate p53 protein accumulation by immunostaining with monoclonal antibody (MAb) DO-7 and p53 gene mutation by single-strand conformation polymorphism analysis of exons 5-8. Nuclear p53 accumulation was detected in 23% of tumours and mutation in 28%. Concordance between the 2 alterations was observed in 73% of cases. p53 protein accumulation was more frequent in tumours with lymph node metastasis, while p53 mutations were more frequent in tumours from older patients. The histopathological parameters of depth of invasion, grade and histological type showed no significant associations with either p53 alteration. In univariate analysis, both alterations were associated with significantly shortened patient survival. The 5-year survival rate for patients with a p53 mutation was 9% compared to 42% for those without a mutation. In multivariate analysis adjusted for the other histopathological parameters, p53 gene mutation but not immunohistochemically-detected p53 protein accumulation was an independent prognostic indicator of poor survival in gastric carcinoma. © 1996 Wiley-Liss, Inc. 相似文献
103.
104.
105.
OBJECTIVE: To determine the role of congenitally displaced ureteral orifices in causing vesicoureteral reflux (VUR) in individuals with spinal cord injury (SCI). DESIGN: Retrospective chart review. PARTICIPANTS: Men and women with (UMN) neurogenic bladders secondary to SCI. MAIN OUTCOME MEASURES: Position of the ureteral orifice and urodynamic parameters in association with VUR. METHODS: A retrospective chart review was performed to identify SCI participants with and without reflux who had evaluation with cystoscopy, cystogram, and urodynamics. The position of ureteral orifice was compared in individuals with SCI who did and did not have ureteral reflex. All cystogram studies were interpreted by board-certified radiologists. The International Classification system was used to grade the severity of the reflux. Fisher exact test was used to evaluate the association of the posterior ureteral orifice and reflux. Analysis also was performed to evaluate the association of reflux with posterior-placed ureteral orifices and urodynamic parameters in the reflux group and nonreflux group. RESULTS: Fifteen participants were found to have reflux--11 had posterior-placed ureteral orifices, whereas 4 had normally positioned orifices. The 11 individuals with posterior-placed ureteral orifices had no bladder wall trabeculation. However, all 4 individuals with normally positioned ureteral orifices had severe trabeculation. Seventeen participants did not exhibit reflux--2 had posteriorly placed ureteral orifices and 15 had normally positioned orifices. Association of posterior position and reflux (P = 0.004). No differences were found with regard to bladder capacity, bladder wall compliance, or voiding pressures between the reflux group and nonreflux group. CONCLUSION: Congenitally displaced ureteral orifices are an important cause of VUR in individuals with SCI. Participants with normally positioned ureteral orifices only had reflux in the presence of severe trabeculation. This study suggests that annual screening with cystograms may not be necessary in individuals with normally positioned ureteral orifices and no significant trabeculation. 相似文献
106.
G P Jeffrey A M Brind D G Ormonde C K Frazer J Ferguson R Bell A Kierath W D Reed A K House 《The Australian and New Zealand journal of surgery》1999,69(10):717-722
BACKGROUND: A review of biliary tract complications was performed in 32 patients who underwent liver transplantation by the Western Australian Liver Transplantation Service during a 2-year period. METHODS: A review was made of patient data collected prospectively, and confirmed by retrospective casenote review. RESULTS: A total of 30 patients (31 grafts) survived more than 2 days after transplantation, and of these 28 had an end-to-end biliary anastomosis. Analysis of these 28 patients found that eight of 17 patients with T-tubes had complications: three leaks at T-tube removal; two strictures and leaks; and three strictures. Six of 11 patients without a T-tube had complications: one leak; three strictures and leaks; and two strictures. Predisposing factors were present in eight of the 14 patients with biliary tract complications: hepatic artery stenosis in three; and one each with hepatic artery thrombosis; biliary calculi; donor-recipient bile duct mismatch; severe cellular rejection: and prolonged postoperative hypotension. Acute rejection, steroid-resistant rejection and cytomegalovirus infection were all significantly more common in those patients with biliary tract complications compared with those without. There was no difference in cold ischaemic time or donor age. Twelve of the 14 patients with biliary complications required endoscopic stenting with or without balloon dilation, and eight patients required radiological percutaneous drainage of bile collections. Only one patient required biliary reconstruction and two patients required re-transplantation. One patient died of uncontrolled infection. Of three patients who underwent choledochojejunostomy, biliary leak developed in two patients, both of whom required operative biliary and hepatic repair. One of the three patients died from disseminated Aspergillus infection. The median total hospital stay of patients with biliary complications was 61 days (range: 30-180 days) compared with 33.5 days (range: 22-70 days) for patients without. Of patients with end-to-end biliary anastomosis, 50% had biliary tract complications and more than half of these had predisposing factors. The majority of biliary complications were managed without the need for surgery. CONCLUSION: A total of 50% of patients with end-to-end biliary anastomosis had biliary tract complications. Biliary strictures presented later than leaks, and the majority of these complications were managed without the need for surgery. 相似文献
107.
108.
109.
110.
KH Nyqvist GC Anderson N Bergman A Cattaneo N Charpak R Davanzo U Ewald S Ludington‐Hoe S Mendoza C Pallás‐Allonso JG Peláez J Sizun A‐M Widström 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(6):812-819
Since Kangaroo Mother Care (KMC) was developed in Colombia in the 1970s, two trends in clinical application emerged. In low income settings, the original KMC model is implemented. This consists of continuous (24 h/day, 7 days/week) and prolonged mother/parent–infant skin‐to‐skin contact; early discharge with the infant in the kangaroo position; (ideally) exclusive breastfeeding; and, adequate follow‐up. In affluent settings, intermittent KMC with sessions of one or a few hours skin‐to‐skin contact for a limited period is common. As a result of the increasing evidence of the benefits of KMC for both infants and families in all intensive care settings, KMC in a high‐tech environment was chosen as the topic for the first European Conference on KMC, and the clinical implementation of the KMC model in all types of settings was discussed at the 7th International Workshop on KMC. Kangaroo Mother Care protocols in high‐tech Neonatal Intensive Care Units (NICU) should specify criteria for initiation, kangaroo position, transfer to/from KMC, transport in kangaroo position, kangaroo nutrition, parents’ role, modification of the NICU environment, performance of care in KMC, and KMC in case of infant instability. Conclusion: Implementation of the original KMC method, with continuous skin‐to‐skin contact whenever possible, is recommended for application in high‐tech environments, although scientific evaluation should continue. 相似文献