Pharmacological aspects of neonatal antidepressant withdrawal

Depression is common in reproductive age women, and continued pharmacologic treatment of depression during pregnancy may be necessary to prevent relapse, which could be harmful for both the fetus and the mother. Although data on drug safety are imperfect and incomplete, the benefits of antidepressant therapy during pregnancy generally outweigh the risks. Neonates who are exposed to antidepressant medications during gestation are at increased risk to have neonatal withdrawal syndrome, although the exact incidence of this complication is unknown because the definition of the syndrome is not clear and withdrawal reactions are probably underreported. Tricyclic antidepressant withdrawal syndrome is most likely related to muscarinergic activity and individual drug half-lives, and selective serotonin reuptake inhibitor withdrawal may be due to a decrease in available synaptic serotonin in the face of down-regulated serotonin receptors, the secondary effects of other neurotransmitters, and biological or cognitive sensitivity. Other factors that influence neonatal toxicity or withdrawal include the normal physiologic changes of pregnancy, the altered activity of CYP450 enzymes during pregnancy, drug-drug transporter (PgP and OCT3) interaction, and the presence of genetic polymorphisms in genes influencing drug metabolism. Further research is necessary. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this article, the reader should be able to explain the importance of antidepressant therapy during pregnancy and postpartum, summarize the important neonatal effects of antidepressants, and describe the potential teratogenic effects of antidepressants.     

Zur Antigenität des Yoshida-Sarkoms der Ratte

Zusammenfassung Homogenisiertes Yoshida-Sarkomgewebe wurde mit halogeniertem Kohlenwasserstoff extrahiert. Mit diesem Extrakt wurden Kaninchen immunisiert und Ratten vor der Sarkomimplantation behandelt. Mit beiden Methoden war es nicht möglich, ein Yoshida-Sarkom-spezifisches Antigen nachzuweisen.

---

Specific antigens of the Yoshida sarcoma

Summary Fluorocarbon extracts from Yoshida sarcoma tissue were used to immunize rabbits and also to treat rats before transplantation. It was not possible with either method to demonstrate a specific antigen of the Yoshida sarcoma.

---

---

Ergänzende Mitteilung zur Arbeit Scheiffarth u. Mitarb. in dieser Z. 70, 178 (1967).     

Sella Turcica und Hypophyse

Journal of Molecular Medicine -     

Schwangerschaftsödeme und Aussentemperatur

Journal of Molecular Medicine -