全文获取类型
收费全文 | 1898篇 |
免费 | 239篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 62篇 |
妇产科学 | 69篇 |
基础医学 | 299篇 |
口腔科学 | 10篇 |
临床医学 | 227篇 |
内科学 | 439篇 |
皮肤病学 | 38篇 |
神经病学 | 186篇 |
特种医学 | 144篇 |
外科学 | 240篇 |
综合类 | 34篇 |
现状与发展 | 1篇 |
预防医学 | 142篇 |
眼科学 | 12篇 |
药学 | 113篇 |
肿瘤学 | 121篇 |
出版年
2023年 | 31篇 |
2022年 | 14篇 |
2021年 | 26篇 |
2020年 | 32篇 |
2019年 | 35篇 |
2018年 | 48篇 |
2017年 | 37篇 |
2016年 | 46篇 |
2015年 | 46篇 |
2014年 | 54篇 |
2013年 | 71篇 |
2012年 | 100篇 |
2011年 | 79篇 |
2010年 | 60篇 |
2009年 | 58篇 |
2008年 | 79篇 |
2007年 | 86篇 |
2006年 | 77篇 |
2005年 | 76篇 |
2004年 | 81篇 |
2003年 | 59篇 |
2002年 | 59篇 |
2001年 | 51篇 |
2000年 | 47篇 |
1999年 | 46篇 |
1998年 | 30篇 |
1997年 | 20篇 |
1996年 | 19篇 |
1995年 | 17篇 |
1994年 | 35篇 |
1993年 | 25篇 |
1992年 | 36篇 |
1991年 | 34篇 |
1990年 | 38篇 |
1989年 | 42篇 |
1988年 | 32篇 |
1987年 | 37篇 |
1986年 | 27篇 |
1985年 | 35篇 |
1984年 | 33篇 |
1983年 | 20篇 |
1982年 | 17篇 |
1981年 | 21篇 |
1980年 | 19篇 |
1979年 | 17篇 |
1978年 | 17篇 |
1977年 | 15篇 |
1976年 | 15篇 |
1975年 | 23篇 |
1973年 | 15篇 |
排序方式: 共有2146条查询结果,搜索用时 78 毫秒
51.
The development and initial validation of a questionnaire to measure help‐seeking behaviour in patients with new onset rheumatoid arthritis 下载免费PDF全文
Rebecca J. Stack BSc MBPsS MSc PhD Christian D. Mallen BMBS FRCGP PhD Chris Deighton BMedSci MD FRCP Patrick Kiely BSc MBBS PhD FRCP Karen L. Shaw BSc MBPsS PgCert PhD Alison Booth RN MSc Kanta Kumar RN MSc Susan Thomas BA MA Ian Rowan Rob Horne BSc MSc PhD MRPharm Peter Nightingale BSc PhD Sandy Herron‐Marx RGN DPSN BA PGcap PhD Clare Jinks BA MPhil PhD Karim Raza FRCP PhD 《Health expectations》2015,18(6):2340-2355
52.
Myopathy in severe asthma. 总被引:8,自引:0,他引:8
J A Douglass D V Tuxen M Horne C D Scheinkestel M Weinmann D Czarny G Bowes 《The American review of respiratory disease》1992,146(2):517-519
Myopathy complicating the therapy of severe asthma has been recently described in several case reports. Twenty-five consecutive patients admitted to the intensive care unit (ICU) at this hospital for mechanical ventilation for severe asthma were studied for the incidence of creatine kinase (CK) enzyme rise and for the development of clinical myopathy. Pharmacologic therapy was standardized, every patient receiving corticosteroids and aminophylline intravenously and salbutamol both nebulized and intravenously. Twenty-two patients received muscle relaxant therapy with vecuronium. In 19 of 25 (76%) of patients there was elevation of CK levels to a median of 1,575 U/L (range, 66 to 7,430) occurring 3.6 +/- 1.5 days after admission. In nine patients there was clinically detectable myopathy. The presence of either myopathy or CK enzyme rise was associated with a significant prolongation of ventilation time. Arterial blood gas measurements on admission to the ICU revealed a pH (mean +/- SD) of 7.07 +/- 0.21, a PaCO2 of 87.2 +/- 32.7, and a PaO2 (with a high FIO2) of 129 +/- 97 mm Hg; however, no correlation was found between the severity of initial metabolic disturbance and the subsequent development of myopathy. There was no association between the type of corticosteroid administered and the subsequent development of myopathy. Patients with myopathy had received a significantly higher total dose of vecuronium when compared with those who did not develop myopathy (p < 0.001, Kruskal Wallis test). We have therefore found a surprisingly high incidence of CK enzyme rise and myopathy in this group of mechanically ventilated patients with severe asthma.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
53.
C Ferrier M D Esler G Eisenhofer B G Wallin M Horne H S Cox G Lambert G L Jennings 《Hypertension》1992,19(1):62-69
In essential hypertension sympathetic nerve firing is commonly increased. A central nervous system origin has been presumed but not tested directly. To estimate cerebral norepinephrine release in essential hypertension, spillover of norepinephrine into the cerebrovascular circulation was measured by isotope dilution, with high internal jugular venous sampling. Norepinephrine was released into the cerebrovascular circulation in both hypertensive patients and healthy volunteers and was present after administration of the ganglion blocker trimethaphan and in patients with sympathetic nervous failure, indicating that brain neurons and not cerebrovascular sympathetic nerves were the probable source. Although differing among hypertensive patients, norepinephrine spillover on average was higher in the hypertensive patients (153 +/- 41 pmol/min) than in healthy subjects (59 +/- 12 pmol/min; p less than 0.05), and was elevated in six of 17 patients, in whom the accompanying whole body norepinephrine spillover rate was higher than in the remaining 11 patients (p less than 0.01). To test for a possible link between brain norepinephrine release and human sympathetic nervous function, the effect of the tricyclic antidepressant desipramine (0.3 mg/kg i.v.) on both brain and whole body norepinephrine spillover was measured in healthy volunteers. Desipramine lowered the cerebrovascular spillover of norepinephrine, its precursor dihydroxyphenylalanine, and its metabolite dihydroxyphenylglycol by 50-80% and produced a mean fall of 35% in whole body norepinephrine spillover. One interpretation of these results is that human sympathetic nerve firing is dependent on norepinephrine release within the brain and that increased cerebral norepinephrine release may possibly be present in some patients with essential hypertension, underlying their higher sympathetic nerve firing rates. 相似文献
54.
Kolek MJ Carlquist JF Muhlestein JB Whiting BM Horne BD Bair TL Anderson JL 《American heart journal》2004,148(6):1034-1040
Background
Coronary artery disease (CAD) and, increasingly, diabetes are recognized as having an inflammatory basis. Membrane toll-like receptors (TLRs) activate signaling pathways that up-regulate inflammation. We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is associated with reduced vascular inflammation (assessed by C-reactive protein [CRP]) and a decreased risk for CAD and diabetes.Methods
1894 patients without acute myocardial infarction undergoing coronary angiography were studied. Genotyping was performed by real-time polymerase chain reaction. CAD was defined as ≥70% stenosis. Diabetes was diagnosed by patients' referring physicians. CRP was measured by fluorescence polarization immunoassay. Regression analyses adjusted for traditional cardiac risk factors.Results
Patients averaged 64 ± 11 years of age, and 69% were male. Asp299Gly genotype frequencies were: AA = 0.911 (n = 1725), AG = 0.086 (n = 164), and GG = 0.003 (n = 5), in keeping with Hardy-Weinberg equilibrium. CRP was lower among G-allele carriers (median = 1.11 mg/dL) than wild-type (AA) subjects (1.23 mg/dL, adjusted P = .044). G-allele carriers also had a lower prevalence of CAD (65% vs. 73%, OR = 0.67, CI = 0.46-0.99, adjusted P = .048) and diabetes (11% vs. 18%, OR = 0.63, CI = 0.42-0.95, adjusted P = .029), which persisted in multivariate logistic regression analyses. 299Gly carriage did not affect clinical outcomes nor interact with statin therapy.Conclusions
The TLR4 299Gly allele was associated with reduced CRP levels and, in parallel, a decreased risk of angiographic CAD and clinical diabetes. These findings suggest that down-regulation of innate immune responsiveness could beneficially modify CAD and diabetes risk and might provide a novel basis for genetic risk stratification and therapeutic targeting. 相似文献55.
Dr. John J. Norcini PhD Harry R. Kimball MD Louis J. Grosso MEd Susan C. Day MD Rebecca A. Baranowski MEd Muriel W. Horne 《Journal of general internal medicine》1994,9(7):361-365
Objective: To determine whether changes in the demographic/educational mix of those entering internal medicine from 1986 to 1989 were
associated with differences among them at the time of certification.
Participants: Included in the study were all candidates for the 1989 to 1992 American Board of Internal Medicine certifying examinations
in internal medicine.
Measurements: Demographic information and medical school, residency training, and examination experience were available for each candidate.
Data defining quality, size, and number of subspecialties were available for internal medicine training programs.
Results: From 1990 to 1992, the total number of men and women candidates increased as did the numbers of foreign-citizen non-U.S.
medical school graduates and osteopathic medical school graduates; the number of U.S. medical school graduates remained nearly
constant and the number of U.S.-citizen graduates of non-U.S. medical schools declined. The pass rates for all groups of first-time
examination takers decreased, while the ratings of program directors remained relatively constant. Program quality, size,
and number of subspecialty programs had modest positive relationships with examination performance.
Conclusions: Changes in the characteristics of those entering internal medicine from 1986 to 1989 were associated with declines in performance
at the time of certification. These declines occurred in all content areas of the test and were apparent regardless of program
quality. These data identify some of the challenges internal medicine faces in the years ahead.
Received from the American Board of Internal Medicine, Philadelphia, Pennsylvania.
This research was supported by the American Board of Internal Medicine but does not necessarily reflect its opinions or policies. 相似文献
56.
Learning from the QUEST multicentre feasibility randomization trials in breast reconstruction after mastectomy 下载免费PDF全文
57.
Jonathan M Hill Mushabbar A Syed Andrew E Arai Tiffany M Powell Jonathan D Paul Gloria Zalos Elizabeth J Read Hanh M Khuu Susan F Leitman McDonald Horne Gyorgy Csako Cynthia E Dunbar Myron A Waclawiw Richard O Cannon 《Journal of the American College of Cardiology》2005,46(9):1643-1648
OBJECTIVES: Cytokine mobilization of progenitor cells from bone marrow may promote myocardial neovascularization with relief of ischemia. BACKGROUND: Patients with coronary artery disease (CAD) have low numbers of endothelial progenitor cells compared with healthy subjects. METHODS: Granulocyte colony-stimulating factor (G-CSF), 10 microg/kg/day for five days, was administered to 16 CAD patients. Progenitor cells were measured by flow cytometry; ischemia was assessed by exercise stress testing and by dobutamine stress cardiac magnetic resonance imaging. RESULTS: Granulocyte colony-stimulating factor increased CD34+/CD133+ cells in the circulation from 1.5 +/- 0.2 microl to 52.4 +/- 10.4 microl (p < 0.001), similar to the response observed in 15 healthy subjects (75.1 +/- 12.6 microl, p = 0.173). Indices of platelet and coagulation activation were not changed by treatment, but C-reactive protein increased from 4.5 +/- 1.3 mg/l to 8.6 +/- 1.3 mg/l (p = 0.017). Two patients experienced serious adverse events: 1) non-ST-segment elevation myocardial infarction (MI) 8 h after the fifth G-CSF dose, and 2) MI and death 17 days after treatment. At 1 month after treatment, there was no improvement from baseline values (i.e., reduction) in wall motion score (from 25.7 +/- 2.1 to 28.3 +/- 1.9, p = 0.196) or segments with abnormal perfusion (7.6 +/- 1.1 to 7.7 +/- 1.1, p = 0.916) and a trend towards a greater number of ischemic segments (from 4.5 +/- 0.6 to 6.1 +/- 1.0, p = 0.068). There was no improvement in exercise duration at 1 month (p = 0.37) or at 3 months (p = 0.98) versus baseline. CONCLUSIONS: Granulocyte colony-stimulating factor administration to CAD patients mobilizes cells with endothelial progenitor potential from bone marrow, but without objective evidence of cardiac benefit and with the potential for adverse outcomes in some patients. 相似文献
58.
Sandeep K. Mallipattu Sylvia J. Horne Vivette D’Agati Goutham Narla Ruijie Liu Michael A. Frohman Kathleen Dickman Edward Y. Chen Avi Ma’ayan Agnieszka B. Bialkowska Amr M. Ghaleb Mandayam O. Nandan Mukesh K. Jain Ilse Daehn Peter Y. Chuang Vincent W. Yang John C. He 《The Journal of clinical investigation》2015,125(3):1347-1361
59.
60.