全文获取类型
收费全文 | 160389篇 |
免费 | 14266篇 |
国内免费 | 9555篇 |
专业分类
耳鼻咽喉 | 1422篇 |
儿科学 | 2699篇 |
妇产科学 | 1546篇 |
基础医学 | 15891篇 |
口腔科学 | 2719篇 |
临床医学 | 20966篇 |
内科学 | 20847篇 |
皮肤病学 | 2178篇 |
神经病学 | 6805篇 |
特种医学 | 5810篇 |
外国民族医学 | 51篇 |
外科学 | 13568篇 |
综合类 | 32389篇 |
现状与发展 | 29篇 |
一般理论 | 14篇 |
预防医学 | 14649篇 |
眼科学 | 3538篇 |
药学 | 18304篇 |
133篇 | |
中国医学 | 10197篇 |
肿瘤学 | 10455篇 |
出版年
2024年 | 415篇 |
2023年 | 1668篇 |
2022年 | 4546篇 |
2021年 | 6003篇 |
2020年 | 4813篇 |
2019年 | 3825篇 |
2018年 | 4115篇 |
2017年 | 4334篇 |
2016年 | 4239篇 |
2015年 | 6759篇 |
2014年 | 8683篇 |
2013年 | 9095篇 |
2012年 | 13438篇 |
2011年 | 14390篇 |
2010年 | 11043篇 |
2009年 | 9403篇 |
2008年 | 10831篇 |
2007年 | 10574篇 |
2006年 | 9782篇 |
2005年 | 8697篇 |
2004年 | 6609篇 |
2003年 | 6512篇 |
2002年 | 5131篇 |
2001年 | 4091篇 |
2000年 | 3305篇 |
1999年 | 2491篇 |
1998年 | 1380篇 |
1997年 | 1451篇 |
1996年 | 995篇 |
1995年 | 861篇 |
1994年 | 711篇 |
1993年 | 494篇 |
1992年 | 564篇 |
1991年 | 473篇 |
1990年 | 402篇 |
1989年 | 352篇 |
1988年 | 281篇 |
1987年 | 294篇 |
1986年 | 203篇 |
1985年 | 191篇 |
1984年 | 129篇 |
1983年 | 84篇 |
1982年 | 63篇 |
1981年 | 62篇 |
1980年 | 43篇 |
1979年 | 56篇 |
1978年 | 59篇 |
1977年 | 27篇 |
1976年 | 35篇 |
1973年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
42.
43.
2013年5月至2014年2月对解放军107医院收治的80例腺样体肥大患者采用吸痰管牵拉软腭暴露鼻咽部,并在70°鼻内镜辅助下行肥大腺样体切除术,效果良好,现报告如下。1资料与方法1.1临床资料本组80例中,男43例,女37例,5~13岁,平均7岁,病程9个月~4年。临床症状均有不同程度夜寐打鼾、张口呼吸,伴有鼻塞。其中 相似文献
44.
Yaobin Ouyang Gongmeizi Liu Wenting Xu Zhen Yang Nianshuang Li Chuan Xie Chun Zhou Jiang Chen Yin Zhu Junbo Hong Nonghua Lu 《Oncology Letters》2021,21(2)
Helicobacter pylori (H. pylori) is a main risk factor for gastric cancer (GC). Epithelial-mesenchymal transition (EMT) is involved in the development and progression of H. pylori-associated GC. However, the exact molecular mechanism of this process remains unclear. The AKT/GSK3β signaling pathway has been demonstrated to promote EMT in several types of cancer. The present study investigated whether H. pylori infection induced EMT, and promoted the development and metastasis of cancer in the normal gastric mucosa, and whether this process was dependent on AKT activation. The expression levels of the EMT-associated proteins, including E-cadherin and N-cadherin, were determined in 165 gastric mucosal samples of different disease stages by immunohistochemical analysis. The expression levels of E-cadherin, N-cadherin, AKT, phosphorylated (p-)AKT (Ser473), GSK3β and p-GSK3β (Ser9) were further determined in H. pylori-infected Mongolian gerbil gastric tissues and cells co-cultured with H. pylori by immunohistochemical analysis and western blotting. The results indicated that the expression levels of the epithelial marker E-cadherin were decreased, whereas the expression levels of the mesenchymal marker N-cadherin were increased during gastric carcinogenesis. Their expression levels were associated with H. pylori infection. Furthermore, H. pylori infection resulted in downregulation of E-cadherin expression and upregulation of N-cadherin expression in Mongolian gerbils and GES-1 cells. In addition, an investigation of the associated mechanism of action revealed that p-AKT (Ser473) and p-GSK3β (Ser9) were activated in GES-1 cells following co-culture with H. pylori. Furthermore, following pretreatment of the cells with the AKT inhibitor VIII, the expression levels of E-cadherin, N-cadherin, p-AKT and p-GSK3β did not show significant differences between GES-1 cells that were co-cultured with or without H. pylori. The levels of p-AKT and p-GSK3β were increased in H. pylori-infected Mongolian gerbils. In conclusion, the present study demonstrated that H. pylori infection activated AKT and resulted in the phosphorylation and inactivation of GSK3β, which in turn promoted early stage EMT. These effects were AKT-dependent. This mechanism may serve as a prerequisite for GC development. 相似文献
45.
目的:探讨血清亮氨酸氨基肽酶(LAP)在妊娠妇女不同时期血清中的变化规律及其临床意义。方法:选取2011年1月~2013年12月在该院产检的正常妊娠妇女180例,根据孕周分为早期组、中期组和晚期组,每组各60例,另选取60例健康未孕妇女为未孕组;同时选取该院收治的妊娠期高血压疾病妇女33例为妊娠期高血压疾病组、早产孕妇22例为早产组,采用速率法分别检测各组孕妇血清LAP水平并进行比较。结果:未孕组、早期组、中期组、晚期组妇女的血清LAP、血清肝胆酸(CG)、碱性磷酸酶(ALP)、α-L-岩藻糖苷酶(AFU)水平比较,差异有统计学意义(P均<0.05)。妊娠期高血压疾病组的CG、ALP、AFU、LAP水平显著高于早期组、中期组和晚期组(P均<0.05);早产组的CG、ALP、AFU、LAP水平显著高于早期组、中期组(P均<0.05),仅CG水平高于晚期组(P<0.05)。结论:随着妊娠周期的增加,妊娠妇女的血清LAP水平逐步升高,在合并妊娠期高血压疾病时LAP升高更加显著,结合CG、ALP、AFU水平的变化能够对妊娠期高血压疾病的发病情况进行动态监测。 相似文献
46.
47.
48.
工作相关肌肉骨骼疾患(WMSDs)是常见的慢性非传染性疾病。WMSDs已成为影响工人健康、降低工人生命质量和造成经济损失的重要因素,可见于多个行业、工种。本文对WMSDs流行现状及人体工效学负荷相关研究进行综述,以期找到职业人群保护的可行方法。 相似文献
49.
痘病毒是自然界普遍存在的DNA病毒,能够高效表达外源基因,诱导较强的细胞免疫和体液免疫,受到基因治疗学者的广泛关注。痘病毒发生同源重组的概率较低,所以有效地筛选和纯化痘病毒十分重要。目前常用的筛选重组痘病毒方法有基于CRISPR进行筛选;根据报告基因GFP、LacZ、GPT等进行筛选;利用TK-和Brdu结合荧光进行筛选;利用药物抗性基因与荧光或显色基因融合,即可在药物筛选的同时观察荧光或显色基因表达情况。本文旨在对目前常用的痘病毒的筛选纯化方法进行综述。 相似文献
50.
Su Jeong Seong Jin Pyo Hong Bong-Jin Hahm Hong Jin Jeon Jee Hoon Sohn Jun Young Lee Maeng Je Cho 《Journal of Korean medical science》2015,30(11):1675-1681
While decreasing trend in gender differences in alcohol use disorders was reported in Western countries, the change in Asian countries is unknown. This study aims to explore the shifts in gender difference in alcohol abuse (AA) and dependence (AD) in Korea. We compared the data from two nation-wide community surveys to evaluate gender differences in lifetime AA and AD by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Face-to-face interviews using the Composite International Diagnostic Interview (CIDI) were applied to all subjects in 2001 (n=6,220) and 2011 (n=6,022). Male-to-female ratio of odds was decreased from 6.41 (95% CI, 4.81-8.54) to 4.37 (95% CI, 3.35-5.71) for AA and from 3.75 (95% CI, 2.96-4.75) to 2.40 (95% CI, 1.80-3.19) for AD. Among those aged 18-29, gender gap even became statistically insignificant for AA (OR, 1.59; 95% CI, 0.97-2.63) and AD (OR, 1.18; 95% CI, 0.80-2.41) in 2011. Men generally showed decreased odds for AD (0.55; 95% CI, 0.45-0.67) and women aged 30-39 showed increased odds for AA (2.13; 95% CI 1.18-3.84) in 2011 compared to 2001. Decreased AD in men and increased AA in women seem to contribute to the decrease of gender gap. Increased risk for AA in young women suggests needs for interventions. 相似文献