全文获取类型
收费全文 | 3676篇 |
免费 | 460篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 131篇 |
妇产科学 | 43篇 |
基础医学 | 421篇 |
口腔科学 | 48篇 |
临床医学 | 524篇 |
内科学 | 1041篇 |
皮肤病学 | 120篇 |
神经病学 | 252篇 |
特种医学 | 354篇 |
外科学 | 417篇 |
综合类 | 48篇 |
一般理论 | 1篇 |
预防医学 | 262篇 |
眼科学 | 98篇 |
药学 | 209篇 |
中国医学 | 6篇 |
肿瘤学 | 182篇 |
出版年
2024年 | 9篇 |
2023年 | 76篇 |
2022年 | 92篇 |
2021年 | 172篇 |
2020年 | 141篇 |
2019年 | 98篇 |
2018年 | 168篇 |
2017年 | 110篇 |
2016年 | 128篇 |
2015年 | 123篇 |
2014年 | 192篇 |
2013年 | 210篇 |
2012年 | 196篇 |
2011年 | 168篇 |
2010年 | 144篇 |
2009年 | 175篇 |
2008年 | 150篇 |
2007年 | 146篇 |
2006年 | 136篇 |
2005年 | 111篇 |
2004年 | 97篇 |
2003年 | 79篇 |
2002年 | 74篇 |
2001年 | 73篇 |
2000年 | 35篇 |
1999年 | 56篇 |
1998年 | 93篇 |
1997年 | 105篇 |
1996年 | 94篇 |
1995年 | 74篇 |
1994年 | 56篇 |
1993年 | 61篇 |
1992年 | 48篇 |
1991年 | 31篇 |
1990年 | 37篇 |
1989年 | 62篇 |
1988年 | 64篇 |
1987年 | 39篇 |
1986年 | 31篇 |
1985年 | 37篇 |
1984年 | 23篇 |
1983年 | 17篇 |
1982年 | 18篇 |
1981年 | 15篇 |
1980年 | 16篇 |
1979年 | 11篇 |
1977年 | 9篇 |
1976年 | 11篇 |
1975年 | 9篇 |
1971年 | 8篇 |
排序方式: 共有4181条查询结果,搜索用时 15 毫秒
21.
Hussey SM Gander R Southern P Hoang MP 《Archives of pathology & laboratory medicine》2005,129(6):794-797
Primary subcutaneous phaeohyphomycosis can rarely be caused by Cladophialophora bantiana, and we present the histologic and culture findings of such a case. A 32-year-old African American woman with systemic lupus erythematosus presented with a 2-year history of multiple, recurrent, tender, and ulcerated skin nodules with purulent drainage on her upper back. Histologic sections of the excision demonstrated features of phaeohyphomycosis. Culture findings were characteristic of C bantiana. Of interest, at age 10 she had sustained traumatic implantation of wood splinters into this area during a tornado, yet clinical symptoms of a subcutaneous infection did not manifest until she developed lupus erythematosus at age 27. Our case highlights the role of trauma and immunosuppression in the pathogenesis of subcutaneous phaeohyphomycosis. 相似文献
22.
Naive or preimmunized (to B10.BR or BALB.k) C3H/HeJ mice received skin grafts from multiple minor histoincompatible B10.BR or BALB.k mice following antigen-specific portal venous (p.v.) pretransplant transfusion, a protocol known to produce prolongation of graft survival in naive animals. In addition, groups of mice received intravenous (i.v.) infusion following transplantation with a mixture of monoclonal antibodies (mAb) to vascular adhesion molecule-1L: very late activation antigen-4 (VCAM-1:VLA-4) or intracellular adhesion molecule-1:lymphocyte function-associated antigen-3 (ICAM-1:LFA-1). Cells were harvested from different tissues of the grafted mice at various times post grafting. RNA was extracted and analysed, using polymerase chain reaction, for expression of different cytokines potentially involved in the regulation of graft rejection [interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumour necrosis factor-alpha, interferon-gamma and transforming growth factor-beta]. In addition, using limiting dilution analysis, we investigated the frequency of allo-specific and third-party reactive cells producing IL-2 and IL-4 in vitro in different tissues of grafted mice following these treatments. The mAb treatment protocol which produced optimum increases in graft survival in naive versus immune mice was different, with anti-LFA-1:ICAM-1 superior for naive mice compared with anti-VLA-4:VCAM-1, and vice versa for immune animals. However, in each case, increased survival was associated with increases local to the graft in the frequency of occurrence of antigen-specific type-2 cytokine-producing cells. 相似文献
23.
Hoang MP Rogers BB Dawson DB Scheuermann RH 《American journal of clinical pathology》1999,111(5):655-659
Human herpesviruses are associated with morbidity and mortality in persons with compromised immune systems, including patients infected with human immunodeficiency virus (HIV). To investigate the basis for this association, the levels of all 8 human herpesviruses (herpes simplex virus, types 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6, human herpesvirus 7, and human herpesvirus 8) were measured with the quantitative polymerase chain reaction (PCR). Viral DNA was measured in the whole blood of 20 HIV-infected patients and compared with levels in 20 healthy blood donors. There was no significant difference in the frequency of virus detection of the 8 human herpesviruses between HIV-infected patients and healthy adults. These results indicate that HIV infection is not associated with a general increase in the circulating levels of human herpesviruses, and suggest that quantitative PCR analysis is superior to qualitative PCR analysis for detection of clinically relevant disease in HIV-infected patients. 相似文献
24.
Mark J Elder MD FRACS FRACO Paul Hiscott PhD FRCS MRCPath John K.G Dart DM FRCS FRCOphth 《Human pathology》1997,28(12):1348-1354
Cicatricial conjunctivitis may be a sequel to systemic disorders (eg, Stevens-Johnson syndrome, cicatricial pemphigoid) or local disorders such as chemical burns. The cicatrisation is often associated with corneal epithelial changes that cause visual loss. These have been attributed to encroachment of the conjunctival epithelium over the cornea. However, the epithelial anomalies are poorly understood. We investigated the corneal epithelial changes in cicatricial conjunctivitis with an immunohistochemical study of intermediate filaments in normal and pathological specimens. Our results show that the normal corneal epithelium is immunoreactive for cytokeratin 3 (CK 3) but not cytokeratin 19 (CK 19), whereas normal conjunctival epithelium is CK 3 negative and CK 19 positive. Conjunctiva artificially transposed over the cornea (after therapeutic conjunctival flap reconstruction) retained the normal pattern of conjunctival cytokeratin expression (CK 3 negative, CK 19 positive). Conversely, the entire corneal epithelium exhibited the normal cytokeratin pattern (CK 3 positive, CK 19 negative) in 82% of Stevens-Johnson, 80% of cicatricial pemphigoid, and 69% of chemical burns specimens. The findings suggest that conjunctival encroachment is not responsible for the changes at the corneal surface in cicatricial conjunctivitis and that the abnormal corneal epithelium is derived from native corneal cells in these diseases. 相似文献
25.
26.
0 引言 急性乳腺炎是产后妇女的常见病 .我们采用针头挑拨治疗急性乳腺炎 32例 ,疗效显著 .1 临床资料 患者 32例 ,年龄 2 3~ 34 (平均 2 5 .3)岁 ,均为产后哺乳产妇 .其中患乳胀痛为共有症状 .伴发热 10例 ;右侧乳腺炎 14例 ,左侧乳腺炎 16例 ,双侧乳腺炎 2例 ;外上象限胀痛 6例 ,外下象限胀痛 8例 ,内上象限胀痛 7例 ,内下象限胀痛 6例 ,二象限同时胀痛 5例 .乳头均无破损 .患者取卧位 ,显露患乳 ,乳头以碘伏严密消毒后 ,术者持五号针头以指腹常规触诊患乳 ,触摸到肿胀部位后 ,沿乳腺管走行方向找到对应的乳头腺管口 ,以针尖轻轻挑拨… 相似文献
27.
28.
A colorless, parallelepiped crystal of methyl (2R,3S)-N-benzoyl-3-phenylisoserinate belonging to the space group P2l with a = 5.414(4), b = 7.813(1), c = 17.802(7) , = 90.87(4)°, Z = 2, V = 752.9 3, D
calc = 1.32 g cm–3, and µcalc = 1.02 cm–1 was selected and the structure solved using direct methods. Refinement led to a final R = 0.079 for 819 [F
o 5(Fo)] reflections. Intermolecular hydrogen-bonding interactions are prevalent in the crystal lattice of this compound. 相似文献
29.
Thi Thanh Ha Nguyen Thuy Long Hoang Thi Hoi Nguyen The Tram Nguyen Lundström G Olsson-Liljequist B Kallings I 《International journal of antimicrobial agents》1991,1(2-3):121-126
The in vitro antimicrobial susceptibilities of 675 common enteropathogenic isolates from faecal specimens of patients with diarrhea (E. coli, Shigella, Salmonella and V. cholerae), and 568 E. coli isolates from faecal flora of healthy persons, which were collected as part of a National antibiotic resistance surveillance in Vietnam, were determined. The agar dilution method was used for the following nine antibiotics: ampicillin, doxycycline, chloramphenicol, gentamicin, nalidixic acid, kanamycin, trimethoprim, trimethoprim in combination with sulfamethoxazole (1/20), and sulfisomidin. Gentamicin was the most active of the antibiotics tested against all bacterial species with MICs in the range 0.125-4 mg/l. All strains were susceptible to nalidixic acid (0.125-8 mg/l) and more than 90% were susceptible to kanamycin. Among E. coli and Shigella isolates from patients the frequencies of resistance to commonly used antibiotics were high: ampicillin 73% and 84%, doxycycline 83% and 94%, chloramphenicol 71% and 91%, sulfisomidin 82% and 92%, respectively. Resistance to trimethoprin, as well as to the combination with sulfamethoxazole was found in 21% and 23%, respectively. The frequencies of multiple resistance (resistance to three or more antibiotics) were also high (77% and 89%, respectively). Less than 10% of Salmonellae and V. cholerae isolates were resistant to ampicillin, sulfisomidin or trimethoprim. Among E. coli from healthy people the frequencies of resistance were lower than in isolates from patients: ampicillin 23%, doxycycline 40%, chloramphenicol 21% and sulfisomidin 34%. However, the same patterns of multiple resistance were found in both groups. 相似文献
30.