全文获取类型
收费全文 | 44338篇 |
免费 | 2260篇 |
国内免费 | 270篇 |
专业分类
耳鼻咽喉 | 266篇 |
儿科学 | 915篇 |
妇产科学 | 558篇 |
基础医学 | 5618篇 |
口腔科学 | 1083篇 |
临床医学 | 2958篇 |
内科学 | 11451篇 |
皮肤病学 | 764篇 |
神经病学 | 3566篇 |
特种医学 | 1926篇 |
外科学 | 7315篇 |
综合类 | 172篇 |
预防医学 | 1163篇 |
眼科学 | 710篇 |
药学 | 3153篇 |
中国医学 | 92篇 |
肿瘤学 | 5158篇 |
出版年
2023年 | 242篇 |
2022年 | 409篇 |
2021年 | 935篇 |
2020年 | 497篇 |
2019年 | 763篇 |
2018年 | 909篇 |
2017年 | 703篇 |
2016年 | 918篇 |
2015年 | 951篇 |
2014年 | 1311篇 |
2013年 | 1506篇 |
2012年 | 2374篇 |
2011年 | 2700篇 |
2010年 | 1442篇 |
2009年 | 1286篇 |
2008年 | 2260篇 |
2007年 | 2462篇 |
2006年 | 2437篇 |
2005年 | 2462篇 |
2004年 | 2360篇 |
2003年 | 2303篇 |
2002年 | 2297篇 |
2001年 | 1143篇 |
2000年 | 1100篇 |
1999年 | 1136篇 |
1998年 | 608篇 |
1997年 | 496篇 |
1996年 | 467篇 |
1995年 | 374篇 |
1994年 | 342篇 |
1993年 | 316篇 |
1992年 | 766篇 |
1991年 | 672篇 |
1990年 | 685篇 |
1989年 | 648篇 |
1988年 | 560篇 |
1987年 | 492篇 |
1986年 | 486篇 |
1985年 | 435篇 |
1984年 | 313篇 |
1983年 | 261篇 |
1982年 | 118篇 |
1981年 | 122篇 |
1980年 | 110篇 |
1979年 | 249篇 |
1978年 | 157篇 |
1977年 | 142篇 |
1975年 | 109篇 |
1972年 | 112篇 |
1971年 | 106篇 |
排序方式: 共有10000条查询结果,搜索用时 977 毫秒
151.
152.
153.
154.
Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue. 总被引:10,自引:0,他引:10
Many Tau-positive glia with paired nuclei and astrocyte type morphology were identified in three brains from patients with progressive supranuclear palsy (PSP). They were positive by Bielschowsky's and Bodian's silver staining as well as by immunostaining with Tau-2, Alz-50, anti-GFAP and anti-paired helical filament antibodies, but not with anti-ubiquitin antibody. They were predominantly localized in the striatum, thalamus and frontal cortex but were not seen in white matter and were not plentiful in areas of heavy neuronal degeneration. Electron microscopy clearly showed the nuclear pairing and localized the Tau protein to bundles suggestive of microtubules in the cytoplasm and proximal processes. Such glial cells were rarely seen in cases of other neurodegenerative diseases or neurologically normal controls. These data suggest that there is an unusual gliotic reaction in PSP in brain areas which show relatively little neuronal loss. 相似文献
155.
Hiromitsu Matsuzaki Hiroyuki Hata Norio Asou Minoru Yoshida Fumihiko Matsuno Motohiro Takeya Kazunari Yamaguchi Isao Sanada Kiyoshi Takatsuki 《Cancer science》1992,83(5):450-457
A stable cell line, KHM-3S, was established from a patient with small cell lung cancer (SCLC), who had a high serum level of soluble interleukin 2 receptors (sIL2-R) and was seropositive for human T cell leukemia virus (HTLV)-l. KHM-3S cells were positive for IL2-R (Tac) and NKH-1, but negative for other lymphocytic markers such as OKT 11, OKT 4, OKT 8, T cell receptor (WT 31), B 1, and B 4. Moreover, the KHM-3S cells were negative for leukocyte common antigen and strongly positive for neuron-specific enolase (NSE). Secretion of sIL2-R and NSE by the KHM-3S line was detected by an enzyme-linked immunosorbent assay. Rearrangement of the T cell receptor gene and monoclonal HTLV-1 integration were found by Southern blot analysis of KHM-3S DNA. However, Northern blot analysis showed no T cell receptor mRNA. KHM-3S may be useful for studies on the role of HTLV-1 in carcinogenesis and IL2-R expression in SCLC. 相似文献
156.
The clinical significance of eosinophils in urine was examined. Eosinophils were found in 9 out of 10 cases of interstitial cystitis, and there were more than 50 eosinophils in 50 fields in 6 of these cases. Although the number of eosinophils almost correlated with the number of leucocytes, the relationship between eosinophils and leucocytes in interstitial cystitis was different in acute and chronic cystitis. Since urinary eosinophils could be observed in cases of interstitial cystitis in which leucocytes were as low as 3 to 10 per field and the number of eosinophils was not decreased by chemotherapy, the urinary eosinophils in interstitial cystitis may be of allergic significance and reflect eosinophilic infiltration into the bladder wall. 相似文献
157.
Hiroyuki Kumamoto Takahiro Suzuki Kiyoshi Ooya 《Journal of oral pathology & medicine》2002,31(10):605-611
BACKGROUND: To clarify the possible role of nitric oxide (NO) and stress proteins in oncogenesis and cytodifferentiation of odontogenic epithelium. Inducible NO synthase (iNOS) and heat shock proteins (HSPs) were analyzed in ameloblastomas as well as in tooth germs. METHODS: Specimens of seven tooth germs, 36 benign ameloblastomas and five malignant ameloblastomas were examined by immunohistochemistry using antibodies against iNOS and 27-, 60- and 70-kDa HSPs (HSP27, HSP60 and HSP70). RESULTS: Immunoreactivity for iNOS was detected in normal and neoplastic odontogenic epithelial cells and was higher in malignant ameloblastomas than in tooth germs and benign ameloblastomas. HSP27 was expressed constitutively in all odontogenic epithelial cells in tooth germs and benign and malignant ameloblastomas. Expression of HSP60 and HSP70 was detected in normal and neoplastic odontogenic epithelial cells and was prominent in cells neighboring the basement membrane. HSP60 reactivity showed no apparent difference between normal and neoplastic odontogenic epithelium, whereas HSP70 expression was slightly higher in benign and malignant ameloblastomas than in tooth germs. CONCLUSIONS: Activation of iNOS might be associated with malignant potential of epithelial odontogenic tumors. Elevated expression of HSP70 is considered to be involved in neoplastic transformation of odontogenic epithelial cells. 相似文献
158.
K Tozawa H Washida H Watanabe Y Noguchi M Kato Y Yamada 《Hinyokika kiyo. Acta urologica Japonica》1992,38(2):223-226
We report 3 cases of müllerian duct cyst. Percutaneous puncture, aspiration and instillation of a sclerosing agent under ultrasound guidance was performed in each case. Ultrasound is valuable in the diagnosis is of cysts in the region of the prostate and seminal vesicles. Aspiration under ultrasound guidance would also be of therapeutic value. 相似文献
159.
Kunihiko Sasai Takashi Adachi Kouki Togano Ei Wakabayashi Hiroyuki Ohnari Hirokazu Iida 《The spine journal》2006,6(4):464-467
BACKGROUND CONTEXT: There is no report in the literature of two-level disc herniation in the cervical and thoracic spine presenting with spastic paresis/paralysis exclusively in the bilateral lower extremities. PURPOSE: To identify the clinical characteristics of specific myelopathy resulting from C6-C7 disc herniation through a case with spastic paresis in the lower extremities without upper extremities symptoms due to separate disc herniation in the cervical and thoracic spine, which was surgically removed in two stages. STUDY DESIGN/SETTING: A case report. METHODS: A 48-year-old man developed a gait disturbance as well as weakness and numbness in the lower extremities. Thoracic magnetic resonance imaging (MRI) showed a T11-T12 disc herniation, which was removed under the surgical microscope through a minimally invasive posterior approach. He improved, but 2 months after surgery developed recurrent numbness and spasticity. On this occasion, no evidence of recurrence of the thoracic disc herniation could be identified, but cervical MRI demonstrated a compressed spinal cord at the C6-C7 level. The patient had no neurological findings in the upper extremities. The herniated disc at C6-C7 was removed under the surgical microscope with laminoplasty. RESULTS: The symptoms gradually improved after surgery. At the present time, 2 years and 9 months after the initial operation, the patient had a stable gait and was able to work. CONCLUSIONS: Our experience suggests that in the diagnosis of patients with spastic paresis and sensory disturbances in the lower extremities, spinal cord compression should be explored by imaging studies not only in the thoracic spine but also in the cervical spine, especially at the C6-C7 level, even if the symptoms and abnormal neurological findings are absent in the upper extremities. 相似文献
160.
Teruo Iwasaki Katsuhiro Nakagawa Motoaki Yasukawa Hiroyuki Shiono Teruaki Nagano Kunimitsu Kawahara 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(1):35-39
Ectopic cervical or cervico-mediastinal thymomas are very rare and most of them are asymptomatic, except for the presence
of a cervical mass. We present the case of a 71-year-old man with an ectopic cervico-mediastinal thymoma threatening superior
vena cava syndrome. He had a slight headache and presented with venous dilatation on the chest wall. A computed tomographic
scan and magnetic resonance, imaging of the chest demonstrated a mass extending from the right neck to the hilum, that indented
the trachea and compressed and displaced the brachiocephalic veins anteriorly. Under a right hemicollar incision and median
sternotomy, the mass was resected en bloc together with the thymus. The resected specimen was an encapsulated mass measuring 11×7×4 cm. The pathological diagnosis
was type AB, non-invasive thymoma, confirmed by 3-color flow, cytometry of tumor-derived lymphocytes. Flow cytometry using
biopsy material may contribute to the preoperative diagnosis of ectopic thymoma. 相似文献