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41.
42.
Miho Yamasaki Sachiyo Funakoshi Shohei Matsuda Tomoko Imazu Yoshiaki Takeda Teruo Murakami Yorinobu Maeda 《European journal of clinical pharmacology》2014,70(8):921-924
Purpose
Magnesium oxide (MgO), a short-term osmotic laxative, is converted into MgCl2 under acidic condition in the stomach and then Mg(HCO3)2 in the intestinal tract, where Mg(HCO3)2 induces the water exudation into the intestine. This indicates that the laxative effect of MgO could be attenuated under the suppressed gastric acid secretion. In this study, the possible interaction of MgO with gastric acid secretion inhibitors was evaluated by using electronic patient records of MgO dosage levels.Methods
Defecation was controlled with MgO alone in some patients after colon surgery (n?=?67) and after total gastric resection (n?=?4). Some other patients were treated with a combination use of MgO and H2 receptor antagonist (H2RA) (n?=?14) or proton pump inhibitor (PPI) (n?=?27). The possible drug interaction of MgO with H2RA or PPI was evaluated by comparing dosage levels of MgO used in controlling defecation.Results
In controlling defecation, the daily dosage levels of MgO in patients taking H2RA or PPI and patients with total gastric resection were significantly higher than those patients taking MgO alone after colon surgery. The ratios of good constipation control (controlled well at the dosing level of 1,000 mg MgO) in patients taking H2RA or PPI were significantly lower than that in patients treated with MgO alone. In an in vitro study, the solubility of MgO at pH 4.5 was quite low, as compared with that at pH 1.2.Conclusions
When patients received H2RA or PPI, the laxative effect of MgO is decreased possibly due to the low solubility of MgO at the higher gastric pH and less generation of MgCl2 and Mg(HCO3)2. Higher dosing level of MgO or another laxative should be used in patients taking H2RA or PPI, as well as the case of patients with total gastric resection. 相似文献43.
Koki Chiba Hiroshi Nomoto Akinobu Nakamura Kyu Yong Cho Kumiko Yamashita Yui Shibayama Aika Miya Hiraku Kameda Yoshio Kurihara Shin Aoki Tatsuya Atsumi Hideaki Miyoshi 《Journal of diabetes investigation.》2021,12(2):176-183
Aims/IntroductionSodium–glucose cotransporter 2 inhibitors (SGLT2i) are used worldwide because of their multiple benefits for patients with type 2 diabetes. The purpose of this study was to determine the efficacy and safety of SGLT2i in patients with type 1 diabetes.Materials and MethodsPatients with type 1 diabetes who had been treated with SGLT2i for >12 weeks were included in this retrospective observation study. We recorded the changes in body mass, insulin dose, blood and urine test data, and adverse events. The changes in day‐to‐day glucose variability, as the primary end‐point, was evaluated using the interquartile range (P25/P75) of the ambulatory glucose data obtained using continuous glucose monitoring.ResultsA total of 51 patients (37 women; mean age 52.7 years) were included. Glycated hemoglobin and body mass significantly decreased by 0.4% and 1.6 kg, respectively. The total required insulin dose decreased by 9.4% (42.7 ± 26.6–38.7 ± 24.3 units/day). Continuous glucose monitoring data were obtained from 30 patients. P25/P75 decreased by 17.6 ± 20.7% during SGLT2i treatment (P < 0.001). The percentage of time per day within the target glucose range of 70–180 mg/dL significantly increased (from 42.2 to 55.5%, P < 0.001), without an increase in the percentage of time spent in the hypoglycemic range (<70 mg/dL). Urinary ketone bodies were detected in four patients (7.8%), but none developed ketoacidosis.ConclusionsSGLT2i improved day‐to‐day glucose variability and time in the target glucose range, without increasing frequency of hypoglycemia, in patients with type 1 diabetes, and reduced glycated hemoglobin, body mass and the required insulin dose. 相似文献
44.
45.
Miyasaka K Ichikawa M Momose K Araki A Kobayashi M Ichimaru Y Funakoshi A 《Archives of gerontology and geriatrics》2004,39(1):83-91
Although the idea that energy metabolism of rats decreases with age has been widely accepted, few studies with regard to the diurnal rhythm of energy expenditure have been reported. Whether age alone altered the diurnal rhythm of energy expenditure was examined in Sprague-Dawley (SD) rats. The same determination was conducted in Otsuka Long Evans Tokushima Fatty (OLETF) rats to examine the effect of insulin resistance and diabetes. OLETF rats were developed as a model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. The characteristic features of OLETF rats are late onset of hyperglycemia at about 18 weeks of age, followed by insulin deficiency at about 65 weeks. Age-associated changes in diurnal rhythm of energy expenditure were not observed in SD rats. In OLETF rats, the diurnal rhythm of energy expenditure with two peaks was observed at 8 weeks of age, while these two peaks disappeared at 24 weeks of age (with NIDDM). Then, the pattern of diurnal rhythm at 44 weeks of age (with advanced NIDDM) was resembled to that of 62 weeks of age (with insulin deficiency). In conclusion, we clarified the changes in diurnal rhythm of energy expenditure associated with the progress of diabetes, while age alone did not alter the diurnal rhythm. 相似文献
46.
Aya Miyazaki MD Hayato Matsutani Yuta Nakano Tadashi Ikeda MD Hideki Uemura MD Hiraku Doi MD 《Pacing and clinical electrophysiology : PACE》2020,43(9):1051-1057
We encountered a unique pattern of cardiac dyssynchrony in a patient with complex congenital heart disease (heterotaxy syndrome) with a biventricular physiology and systemic left ventricle (LV). On speckle tracking echocardiography, dyssynchrony was not detected within the LV, but was noted in an interventricular fashion between the LV and right ventricle (RV). An electrophysiologic study revealed a conduction delay in the subpulmonary RV. Cardiac resynchronization therapy provided reverse cardiac remodeling and an excellent result in our patient by placing the pacing leads around the dyssynchronous lesion. 相似文献
47.
Takeshi Sekiguchi Yoshiaki Kamada Nobuaki Furuno Minoru Funakoshi Hideki Kobayashi 《Genes to cells : devoted to molecular & cellular mechanisms》2014,19(6):449-463
The yeast Ras‐like GTPases Gtr1p and Gtr2p form a heterodimer, are implicated in the regulation of TOR complex 1 (TORC1) and play pivotal roles in cell growth. Gtr1p and Gtr2p bind Ego1p and Ego3p, which are tethered to the endosomal and vacuolar membranes where TORC1 functions are regulated through a relay of amino acid signaling interactions. The mechanisms by which Gtr1p and Gtr2p activate TORC1 remain obscure. We probed the interactions of the Gtr1p‐Gtr2p complex with the Ego1p‐Ego3p complex and TORC1 subunits. Mutations in the region (179–220 a.a.) following the nucleotide‐binding region of Gtr1p and Gtr2p abrogated their mutual interaction and resulted in a loss in function, suggesting that complex formation between Gtr1p and Gtr2p was indispensable for TORC1 function. A modified yeast two‐hybrid assay showed that Gtr1p‐Gtr2p complex formation is important for its interaction with the Ego1p‐Ego3p complex. GTP‐bound Gtr1p interacted with the region containing the HEAT repeats of Kog1p and the C‐terminal region of Tco89p. The GTP‐bound Gtr2p suppressed a Kog1p mutation. Our findings indicate that the interactions of the Gtr1p‐Gtr2p complex with the Ego1p‐Ego3p complex and TORC1 components Kog1p and Tco89p play a role in TORC1 function. 相似文献
48.
Hirotsugu Shinozaki Akihiro Funakoshi M.D. Kyoko Miyasaka Kazunori Miyazaki Kenichi Kitani 《Journal of gastroenterology》1988,23(6):673-679
The effect of somatostatin (SS) on the pancreatic enzyme secretion was studied in a perfusion system using dispersed pancreatic
rat acini in vitro. In addition the effect of SS on pancreatic secretion in vivo was also studied in conscious rats for comparison.
In an in vitro study, 6×10-7M SS-14 caused no significant change in amylase release when added 20 min before stimulation by 10-5M carbamylcholine (Cch), 10-6M A23187, 5×10-7M secretin and 2mM dibutyryl cyclic AMP. The addition of 6×10-7M SS-28 also caused no significant change in amylase release stimulated by 10-5M Cch. High performance liquid chromatographic examination indicated that no degradation of either SS-14 or SS-28 occurred
after reaction with dispersed acini. In an in vivo study SS-14 caused marked inhibition of basal pancreatic secretion and
stimulated pancreatic secretion by bile-pancreatic juice diversion. These results indicate that SS has no direct inhibitory
action on rat pancreatic secretion, and that SS may inhibit the pancreatic secretion by indirect mechanisms. 相似文献
49.
Effect of soybean crude fiber on the concentrations of serum lipids and apolipoproteins in hyperlipemic subjects was examined. The concentrations of serum triglycerides, VLDL triglycerides and VLDL cholesterol were decreased significantly following the administration of soybean crude fiber for 2 months. Neither were significant changes found in total cholesterol, LDL cholesterol, HDL cholesterol, apo A-I, apo A-II, apo C-II and apo B levels, nor in body weight before and after the administration of soybean crude fiber. 相似文献
50.
Kenji Yasue Hiraku Fuse Satoshi Oyama Koichi Hanada Kazuya Shinoda Hideaki Ikoma Tatsuya Fujisaki Yoshio Tamaki 《Journal of radiation research》2022,63(1):137
This study aimed to quantitatively clarify the baseline drift for each respiratory cycle in two respiratory-gating methods using the intra-beam respiratory motion data of lung cancer patients. The residual motion and dose distribution were calculated based on intra-beam respiratory motion data with the baseline drift. To quantify the baseline drift during irradiation, it was defined as the inclination between the detected expiration point and the expiration point in the next cycle in the anterior–posterior (AP), cranial–caudal (CC) and left–right (LR) directions obtained using an in-house programme. The baseline drift value reached up to 0.74 mm/s in the CC direction as per the respiratory motion data of 10 patients. The homogeneity index (HI) of the phase-gating method tended to increase because the target was irradiated even when the amplitude position of the target differed from period to period. In contrast, the amplitude-gating method enabled irradiation considering the amplitude position of the target because the gating window was set considering the amplitude position of the respiratory motion. The respiratory-gating methods and respiratory phase in respiratory-gating lung stereotactic body radiation therapy (SBRT) must be determined based on the respiratory motion of the patients. 相似文献