全文获取类型
收费全文 | 3082篇 |
免费 | 215篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 86篇 |
妇产科学 | 62篇 |
基础医学 | 381篇 |
口腔科学 | 57篇 |
临床医学 | 216篇 |
内科学 | 970篇 |
皮肤病学 | 131篇 |
神经病学 | 133篇 |
特种医学 | 78篇 |
外科学 | 453篇 |
综合类 | 21篇 |
预防医学 | 165篇 |
眼科学 | 70篇 |
药学 | 166篇 |
肿瘤学 | 303篇 |
出版年
2023年 | 25篇 |
2022年 | 41篇 |
2021年 | 39篇 |
2020年 | 42篇 |
2019年 | 48篇 |
2018年 | 75篇 |
2017年 | 82篇 |
2016年 | 77篇 |
2015年 | 94篇 |
2014年 | 97篇 |
2013年 | 92篇 |
2012年 | 136篇 |
2011年 | 167篇 |
2010年 | 97篇 |
2009年 | 71篇 |
2008年 | 133篇 |
2007年 | 166篇 |
2006年 | 159篇 |
2005年 | 177篇 |
2004年 | 147篇 |
2003年 | 164篇 |
2002年 | 160篇 |
2001年 | 100篇 |
2000年 | 89篇 |
1999年 | 74篇 |
1998年 | 39篇 |
1997年 | 18篇 |
1996年 | 19篇 |
1995年 | 22篇 |
1994年 | 22篇 |
1993年 | 21篇 |
1992年 | 50篇 |
1991年 | 60篇 |
1990年 | 49篇 |
1989年 | 59篇 |
1988年 | 41篇 |
1987年 | 59篇 |
1986年 | 28篇 |
1985年 | 22篇 |
1984年 | 21篇 |
1983年 | 23篇 |
1982年 | 12篇 |
1979年 | 32篇 |
1978年 | 18篇 |
1977年 | 24篇 |
1973年 | 11篇 |
1972年 | 11篇 |
1970年 | 14篇 |
1968年 | 13篇 |
1966年 | 14篇 |
排序方式: 共有3323条查询结果,搜索用时 15 毫秒
101.
Tokuhide Doi Masami Akai Naoto Endo Keiji Fujino Tsutomu Iwaya 《Journal of bone and mineral metabolism》2013,31(6):663-673
The objective of this study was to record the clinical course of osteoporosis over time in Japanese women. We hypothesized that successful control of acute pain associated with osteoporosis will allow better treatment for health-related problems. To confirm this working hypothesis, we developed the Japan Questionnaire for Osteoporotic Pain (JQ22) to measure health status associated with osteoporosis. We examined the validity and reliability of the JQ22 compared with the current gold standard scale for back pain, the Roland Morris questionnaire (RDQ). A total of 125 women who were more than 65 years old, had an acute back pain episode, and had a fragile vertebral fracture confirmed by X-ray and clinical signs, participated in this study. The psychometric analyses for validity and reliability were tested for the JQ22 and the RDQ. The time course up to 6 weeks was observed by investigating both changes in pain characteristics and its influence on related activities and social participation. Cronbach’s alpha coefficient was 0.979 and 0.919 for the JQ22 and RDQ, respectively. The Akaike Information Criterion (AIC) indicated that the JQ22 items were separated into four domains, which were sequentially arranged at the baseline and subsequently changed. This structure reflected osteoporotic back characteristics covering a range from pain to social activities. The JQ22 was shown to be a valid and reliable scale for patient-based measurement of osteoporotic back pain. It also revealed both changes in pain characteristics and the influence of pain on related activities and participation. 相似文献
102.
Tomoharu Kiyosawa Toshio Demitsu Toru Murashita Mitsuo Fujimoto Maki Kakurai Mamitaro Ohtsuki Hidemi Nakagawa Yoshio Nakayama 《Journal of plastic surgery and hand surgery》2013,47(3):269-271
A 47-year-old man with an angiosarcoma of the right lower extremity was cured with mainly surgery and radiotherapy despite an inguinal metastasis. Histologically, the amputation stump of the metastatic tumour showed invasion by tumour. Radiotherapy, chemotherapy, and treatment with interleukin-2 was added. Ten years later he has had no recurrence. 相似文献
103.
Akihiko Maeda Sho Carl Shibata Hiroshi Wada Shigeru Marubashi Takahiko Kamibayashi Hidetoshi Eguchi Yuji Fujino 《Journal of anesthesia》2016,30(1):39-46
Purpose
Postoperative pain management for living liver donors has become a major concern as a result of the increasing number of living liver donations. Transversus abdominis plane (TAP) block has been known to provide effective analgesia for abdominal surgery. The aim of this study was to evaluate the efficacy of ultrasound-guided continuous subcostal TAP block as a part of a multimodal analgesic regimen in comparison with conventional intravenous (IV) fentanyl-based analgesia in living liver donors.Methods
Thirty-two donors were retrospectively classified into either the continuous subcostal TAP block group (TAP group) or the IV fentanyl-based analgesia group (control group). TAP group donors received bilateral continuous subcostal TAP infusion of 0.125 % levobupivacaine at 6 ml/h. Control group donors did not receive any neural blockade.Results
Cumulative fentanyl consumption was significantly lower in the TAP group for 48 h (P < 0.01) as compared to the control group. Further, the donors in the TAP group had significantly lower incidence of nausea and vomiting during 24–48 h postoperatively (P < 0.01) and fewer delays in the initiation of oral intake than those in the control group (P = 0.02).Conclusions
In conclusion, continuous subcostal TAP block provided an effective opioid-sparing analgesia for living liver donors.104.
Takekazu Iwata Kaoru Nagato Takahiro Nakajima Hidemi Suzuki Shigetoshi Yoshida Ichiro Yoshino 《Surgery today》2016,46(8):877-886
Postoperative atrial fibrillation (POAF), the most frequent arrhythmia after pulmonary resection, is a cause of both morbidity and mortality. Being able to predict the risk of POAF before surgery would help us evaluate the surgical risk and plan prophylaxis. We investigated the reported preoperative risk factors associated with the incidence of POAF and found that the recommended predictive factors were quite variable. Therefore, we evaluated the previously reported preoperative risk factors for POAF using our institutional data. We discuss our findings in this short review. Male gender, resected lung volume, brain natriuretic peptide (BNP), and left ventricular early transmitral velocity/mitral annular early diastolic velocity (E/e′) calculated by echocardiography were suggested as independent predictors for POAF, but the predictive values of each individual parameter were not high. The lack of definitive predictors for POAF warrants further investigations by gathering the reported knowledge, to establish an effective preoperative examination strategy. 相似文献
105.
Takayoshi?Yamamoto Hidemi?SuzukiEmail author Kaoru?Nagato Takahiro?Nakajima Takekazu?Iwata Shigetoshi?Yoshida Ichiro?Yoshino 《Surgery today》2016,46(7):780-784
Purpose
Cerebral infarction is a rare complication of lung resection that can result in severe sequelae. Our aim was to investigate the characteristics of patients who suffer from cerebral infarction after surgery for lung cancer.Methods
We retrospectively reviewed all patients who underwent resection of at least a single lobe for lung cancer at our institution between January 2008 and October 2013. We compared the patients who presented with cerebral infarction with those patients who did not within 30 days of surgery.Results
A total of 562 patients underwent surgery, with five males and one female subsequently experiencing cerebral infarction. Five patients underwent left upper lobectomy and one underwent left lower lobectomy. Patient age, sex, body mass index, smoking index, and operative time were not significantly different between the six patients with postoperative cerebral infarction and the other 556 patients; only the type of operative procedure was significantly different (p < 0.001). Contrast-enhanced computed tomography revealed thrombosis in the stump of the left superior pulmonary vein in patients with postoperative cerebral infarction.Conclusions
Cerebral infarction occurs at a high frequency in patients who undergo left upper lobectomy for lung cancer. Thrombosis in the left superior pulmonary-vein stump might cause cerebral infarction.106.
Clinical Features and Prognosis of Generalized Lymphatic Anomaly,Kaposiform Lymphangiomatosis,and Gorham–Stout Disease 下载免费PDF全文
107.
Ordered assembly of scaffold proteins Carma1-Bcl10-Malt1 determines NF-kappaB activation following T cell receptor (TCR) engagement. Carma1-Bcl10 interaction and the signaling pathway are controlled by Carma1 phosphorylation, which are induced by PKCtheta and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). In addition to Carma1 phosphorylation, previous studies have demonstrated that Bcl10 is phosphorylated in the C-terminal Ser/Thr rich region following TCR engagement. However the kinases that phosphorylate Bcl10 are incompletely understood. Here we show that CaMKII phosphorylates Bcl10 on Ser138. Furthermore, a CaMKII inhibitor, KN93, and CaMKII siRNA substantially reduce Bcl10 phosphorylation induced by phorbol myristate acetate/ionomycin. S138A mutation prolongs Bcl10-induced NF-kappaB activation, suggesting that Bcl10 phosphorylation is involved in attenuation of NF-kappaB activation. These findings suggest that CaMKII modulates NF-kappaB activation via phosphorylating Bcl10 as well as Carma1. 相似文献
108.
Shingo Ito Yu Fujino Seiryo Ogata Mio Hirayama-Kurogi Sumio Ohtsuki 《Journal of pharmaceutical sciences》2018,107(12):3163-3170
The SLC22A18 gene, which encodes an orphan transporter, is located at the 11p15.5 imprinted region, an important tumor suppressor gene region. However, the role of SLC22A18 in tumor suppression remains unclear. Here, we investigated the involvement of SLC22A18 in cell growth, invasion, and drug resistance of MCF7 human breast cancer cell line. Western blot analysis indicated that SLC22A18 is predominantly expressed at intracellular organelle membranes. Quantitative proteomics showed that knockdown of SLC22A18 significantly altered the expression of 578 (31.0%) of 1867 proteins identified, including proteins related to malignancy and poor prognosis of breast cancer. SLC22A18 knockdown (1) increased MCF7 cell growth concomitantly with a >7-fold increase of annexin A8 (involved in cell growth and migration; a predictor of poor prognosis), (2) induced spherical morphology of MCF7 cells concomitantly with a nearly 3-fold increase of CD44 (involved in regulation of malignant phenotypes), and (3) increased chemosensitivity to vinca alkaloids concomitantly with a >80% reduction of doublecortin-like kinase 1 (involved in regulation of microtubule polymerization). Our results suggest that SLC22A18 may act as a tumor suppressor by regulating the expression levels of cell growth–related proteins, and vinca alkaloids might show therapeutic efficacy against low-SLC22A18–expressing breast cancer. 相似文献
109.
110.
Hagihara Kiyotaka Haraguchi Naotsugu Nishimura Junichi Yasueda Asuka Fujino Shiki Ogino Takayuki Takahashi Hidekazu Miyoshi Norikatsu Uemura Mamoru Matsuda Chu Mizushima Tsunekazu Yamamoto Hirofumi Mori Masaki Doki Yuichiro Eguchi Hidetoshi 《Annals of surgical oncology》2022,29(12):7435-7445
Annals of Surgical Oncology - Colorectal cancer (CRC) is a major cause of cancer-related deaths. Metastasis is enhanced through epithelial-mesenchymal transition (EMT), a process primarily induced... 相似文献