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Multiple primary lung cancers. Results of surgical treatment 总被引:4,自引:0,他引:4
C Deschamps P C Pairolero V F Trastek W S Payne 《The Journal of thoracic and cardiovascular surgery》1990,99(5):769-77; discussion 777-8
During a 13-year period, multiple primary lung cancers were diagnosed in 80 consecutive patients. Forty-four patients had metachronous cancers. The initial pulmonary resection was lobectomy in 36 patients, bilobectomy in 3, pneumonectomy in 1, and wedge excision or segmentectomy in 4. The second pulmonary resection was lobectomy in 16 patients, bilobectomy in 2, completion pneumonectomy in 7, and wedge excision or segmentectomy in 19. There were two 30-day operative deaths (mortality rate, 4.5%). Actuarial 5- and 10-year survival rates after the first pulmonary resection for stage I disease were 55.2% and 27.0%, respectively. Five-year and 10-year survival rates for stage I disease after the second pulmonary resection were 41.0% and 31.5%, respectively. The remaining 36 patients had synchronous cancers. The pulmonary resection was lobectomy in 18 patients, bilobectomy in 3, pneumonectomy in 10, and wedge excision or segmentectomy in 8. There were two 30-day operative deaths (mortality rate, 5.6%). Actuarial overall 5- and 10-year survival rates after pulmonary resection were 15.7% and 13.8%, respectively. We conclude that an aggressive surgical approach is safe and warranted in most patients with multiple primary lung cancers and that the presence of synchronous primary cancers is ominous. 相似文献
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J. B. Payne R. A. Reinhardt M. P. Masada L. M. DuBois A. C. Allison 《Journal of periodontal research》1993,28(6):451-453
Gingival crevicular fluid (GCF) IL-8 and IL-1,1β levels were determined by sandwich enzyme-linked immunosorbent assays. Associations between IL-8 and IL-1β GCF levels, and between these cytokines and patient estrogen status were evaluated. IL-8 and IL-1β were detected more frequently and in higher amounts/30 s GCF sample in estrogen-deficient patients than in estrogensufficient patients. IL-8 and IL-1β GCF levels were significantly correlated. These lindings suggest that GCF IL-8 levels are associated with patient estrogen status and local IL-1β concentrations. 相似文献
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Heather S. Jim Michael A. Andrykowski Pamela N. Munster Paul B. Jacobsen 《Annals of behavioral medicine》2007,34(2):200-208
Background: Studies suggest that the period following completion of treatment can be distressing for cancer patients. One potentially
important predictor of distress is physical symptoms/side effects during treatment.Purpose: A longitudinal, observational design was used to examine whether the number of physical symptoms/side effects experienced
during treatment was a correlate of cancer-related distress and general distress 4 months after treatment completion, as measured
by the Impact of Events Scale and the Mental Health subscale of the Short Form-36, respectively.Methods: Participants were 151 women who had completed chemotherapy and/or radiotherapy for ductal carcinoma in situ or stage 1 or
2 breast cancer. Hierarchical multiple regression was conducted with relevant sociodemographic, clinical, and psychiatric
variables entered as controls.Results: Greater physical symptoms/side effects predicted greater total cancer-related distress, intrusive thoughts, and general distress.
Physical symptoms/side effects did not significantly predict avoidance. Follow-up analyses indicated that the relationship
between physical symptoms/side effects and general distress was mediated by both total cancer-related distress and intrusive
thoughts.Conclusions: These results suggest that patients who experience greater physical symptoms/side effects during treatment are at greater
risk for later cancer-related distress and, in turn, general distress. Future research should evaluate whether early intervention
with these patients is effective in preventing or reducing distress in the posttreatment period.
This work was supported by a grant from the National Cancer Institute (5R01 CA082822). 相似文献
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Percutaneous transluminal angioplasty has been shown to be both feasible and efficacious for the treatment of aortic coarctation. Recent reports, however, have indicated that the development of aortic aneurysms at or near the coarctation segment may complicate attempts to treat this lesion by catheter-based intervention. Accordingly, we examined the light microscopic features of coarctation segments excised at surgery (n = 31) or obtained at autopsy (n = 2) in 33 patients with coarctation of the aorta. Cystic medial necrosis, defined as depletion and disarray of elastic tissue, was observed in each of the 33 specimens. In the majority of coarctation specimens (22 of 33 or 67%) the extent of cystic medial necrosis, graded semiquantitatively on a scale of 0 (normal aorta) to 3+, was severe (3+). The finding that cystic medial necrosis represents a consistent histologic feature of coarctation of the aorta provides a pathologic basis for the formation of aneurysms observed after balloon angioplasty of coarctation sites. 相似文献