全文获取类型
收费全文 | 1703篇 |
免费 | 250篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 58篇 |
妇产科学 | 31篇 |
基础医学 | 101篇 |
口腔科学 | 73篇 |
临床医学 | 287篇 |
内科学 | 424篇 |
皮肤病学 | 38篇 |
神经病学 | 62篇 |
特种医学 | 322篇 |
外科学 | 131篇 |
综合类 | 18篇 |
预防医学 | 286篇 |
眼科学 | 11篇 |
药学 | 31篇 |
肿瘤学 | 92篇 |
出版年
2023年 | 48篇 |
2022年 | 13篇 |
2021年 | 14篇 |
2020年 | 40篇 |
2019年 | 21篇 |
2018年 | 54篇 |
2017年 | 37篇 |
2016年 | 45篇 |
2015年 | 56篇 |
2014年 | 98篇 |
2013年 | 122篇 |
2012年 | 36篇 |
2011年 | 55篇 |
2010年 | 67篇 |
2009年 | 82篇 |
2008年 | 50篇 |
2007年 | 77篇 |
2006年 | 55篇 |
2005年 | 39篇 |
2004年 | 43篇 |
2003年 | 18篇 |
2002年 | 16篇 |
2001年 | 26篇 |
2000年 | 24篇 |
1999年 | 30篇 |
1998年 | 66篇 |
1997年 | 90篇 |
1996年 | 79篇 |
1995年 | 58篇 |
1994年 | 62篇 |
1993年 | 52篇 |
1992年 | 18篇 |
1991年 | 15篇 |
1990年 | 34篇 |
1989年 | 43篇 |
1988年 | 32篇 |
1987年 | 34篇 |
1986年 | 35篇 |
1985年 | 36篇 |
1984年 | 13篇 |
1983年 | 13篇 |
1982年 | 25篇 |
1981年 | 31篇 |
1980年 | 17篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 14篇 |
1976年 | 14篇 |
1975年 | 10篇 |
1969年 | 3篇 |
排序方式: 共有1974条查询结果,搜索用时 15 毫秒
101.
102.
J Broadmore JD Hutton F Langdana 《BJOG : an international journal of obstetrics and gynaecology》2009,116(5):731-733
Medical students usually initially learn vaginal examination (VE) by examining consenting anaesthetised women. To assess their experience of this practice, a questionnaire was distributed to all 66 fifth-year students at the Wellington School of Medicine in 2005—53 students responded. Although 184 women were available to approach for consent, only 141 were approached—students claimed insufficient time as their major difficulty. All male students discussed consent with women only in the 2 hours preoperatively, whereas nine (28%) of the female students sought consent earlier on the day or the day before. Of the 114 women asked, 97 gave written consent, but the VE was conducted in only 76 women mostly because the supervising gynaecologist claimed time constraints or was uninterested. Four other women were examined when consent was uncertain and two without consent. All but one of the students considered the experience educationally valuable. Eleven responding students did not perform a VE, and if the 13 nonresponders also did not, more than one-third of students lack this educational opportunity prior to their final year. In conclusion, some students require more commitment to seeking consent, and some gynaecologists may need to better facilitate this learning opportunity so that the consent agreed with the woman and student is more often respected. 相似文献
103.
C Badenas J To-Figueras JD Phillips CA Warby C Muñoz and C Herrero 《Clinical genetics》2009,75(4):346-353
Porphyria cutanea tarda (PCT) arises from decreased hepatic activity of uroporphyrinogen decarboxylase (UROD). Both genetic and environmental factors interplay in the precipitation of clinically overt PCT, but these factors may vary between different geographic areas. Decreased activity of UROD in erythrocytes was used to identify patients with UROD mutations among a group of 130 Spanish PCT patients. Nineteen patients (14.6%) were found to harbor a mutation in the UROD gene. Eight mutations were novel: M1I, 5del10, A22V, D79N, F84I, Q116X, T141I and Y182C. Five others were previously described: F46L, V134Q, R142Q, P150L and E218G. The new missense mutations and P150L were expressed in Escherichia coli. D79N and P150L resulted in proteins that were localized to inclusion bodies. The other mutations produced recombinant proteins that were purified and showed reduced activity (range: 2.3–73.2% of wild type). These single amino acid changes were predicted to produce complex structural alterations and/or reduced stability of the enzyme. Screening of relatives of the probands showed that 37.5% of mutation carriers demonstrated increased urinary porphyrins. This study emphasizes the role of UROD mutations as a strong risk factor for PCT even in areas where environmental factors (hepatitis C virus) have been shown to be highly associated with the disease. 相似文献
104.
105.
106.
Hazle JD Diederich CJ Kangasniemi M Price RE Olsson LE Stafford RJ 《Journal of magnetic resonance imaging : JMRI》2002,15(4):409-417
PURPOSE: To evaluate MRI-based techniques for visual guidance, thermal monitoring, and assessment during transurethral ultrasound thermal therapy of implanted tumors in an in vivo canine prostate model. MATERIALS AND METHODS: Transmissible venereal tumors (TVT) were grown in the right lobe of the prostate in four dogs. High-temperature thermal therapy was selectively applied to the tumor-bearing lobe using a transurethral ultrasound applicator with a 180 degrees directional heating pattern. Temperature-sensitive MRI (MRTI) using a fast interleaved gradient-echo echo-planar (iGE-EPI) imaging sequence was used for cumulative thermal dose calculations in multiple image planes during the treatment. The results from MRTI-based dose maps and post-treatment MRI were compared to those from histologic analysis. RESULTS: MRTI monitoring in multiple planes across the prostate guided the use and control of a directive ultrasound applicator for the selective ablation of the sections of the prostate that contained implanted tumors. Findings in gadolinium enhanced MRI obtained immediately after thermal therapy slightly underestimated the size of tissue necrosis after treatment, as verified by histopathologic analysis. CONCLUSION: The use of multiplanar MRTI with a transurethral ultrasound applicator shows significant potential for selective thermal ablation of prostate tumor and tissue. 相似文献
107.
Hispanics have been disproportionately impacted by HIV/AIDS. Although HIV risk is significantly elevated among severely mentally
ill persons (SMI), the risk of infection appears to be even greater among those SMI who are Hispanic, reflecting the increased
risk of HIV among Hispanics. We report on findings from the first 41 participants in a qualitative study examining the context
of HIV risk and risk reduction strategies among severely mentally ill Puerto Rican women residents in northeastern Ohio. Individuals
participated in a baseline interview, two follow-up interviews, and up to 100 hours of shadowing. Interviews and shadowing
activities were recorded and analyzed using a grounded theory. The majority of individuals reported using identification with
a religious faith. A large proportion of the participants reported that their religious or spiritual beliefs were critical
to their coping, had influenced them to reduce risk, and/or provided them with needed social support. Several participants
also reported having experienced rejection from their faith communities. The emphasis on spirituality among Puerto Rican SMI
is consistent with previous research demonstrating the importance of spirituality in the Hispanic culture and reliance on
spiritual beliefs as a mean of coping among SMI. Our results support the incorporation of spiritual beliefs into secular HIV
prevention efforts.
Loue is with the Department of Epidemiology and Biostatistics, Center for Minority Public Health, School of Medicine, Case
Western Reserve University, Cleveland, OH, USA; Sajatovic is with the Department of Psychiatry, School of Medicine, Case Western
Reserve University, Cleveland, OH, USA. 相似文献
108.
Jennie C. I. Tsao PhD ; Aram Dobalian PhD JD ; Brenda A. Wiens PhD ; Julius A. Gylys PhD ; Garret D. Evans PsyD 《The Journal of rural health》2006,22(1):78-82
CONTEXT: Recent bioterrorism attacks have highlighted the critical need for health care organizations to prepare for future threats. Yet, relatively little attention has been paid to the mental health needs of rural communities in the wake of such events. A critical aspect of bioterrorism is emphasis on generating fear and uncertainty, thereby contributing to increased needs for mental health care, particularly for posttraumatic stress disorder, which has been estimated to occur in 28% of terrorism survivors. PURPOSE: Prior experience with natural disasters suggests that first responders typically focus on immediate medical trauma or injury, leaving rural communities to struggle with the burden of unmet mental health needs both in the immediate aftermath and over the longer term. The purpose of the present article is to draw attention to the greater need to educate rural primary care providers who will be the frontline providers of mental health services following bioterrorism, given the limited availability of tertiary mental health care in rural communities. METHODS: We reviewed the literature related to bioterrorism events and mental health with an emphasis on rural communities. FINDINGS AND CONCLUSIONS: Public health agencies should work with rural primary care providers and mental health professionals to develop educational interventions focused on posttraumatic stress disorder and other mental disorders, as well as algorithms for assessment, referral, and treatment of post-event psychological disorders and somatic complaints to ensure the availability, continuity, and delivery of quality mental health care for rural residents following bioterrorism and other public health emergencies. 相似文献
109.
Andréa D Bertoldi Aluísio JD Barros Anita Wagner Dennis Ross-Degnan Pedro C Hallal 《BMC health services research》2008,8(1):222
Background
Studies carried out in the community enable researchers to understand access to medicines, affordability, and barriers to use from the consumer's point of view, and may stimulate the development of adequate medicines policies. The aim of the present article was to describe methodological and analytical aspects of quantitative studies on medicine utilization carried out at the household level. 相似文献110.
GL BONACRUZ JD ARNOLD GI LESLIE L. WYNDHAM G. KOUMANTAKIS 《Journal of paediatrics and child health》1996,32(4):299-301
Objective : To determine the approach to identifying neonatal hypoglycaemia and the definition of neonatal hypoglycaemia used by neonatal paediatricians in Australian Level 3 neonatal intensive care units (NICU).
Methodology : A questionnaire was sent to the 101 neonatal paediatricians in the 22 Level 3 NICU in Australia asking their method of screening for, and definition of, neonatal hypoglycaemia.
Results : Responses were received from 70 neonatal paediatricians, including all 22 directors. A bedside glucose meter is used in 19 of 22 NICU to screen for hypoglycaemia, whilst one NICU uses a glucose analyzer and another NICU uses a visual colour comparison method. One NICU does not screen, but has blood glucose measured in a satellite laboratory. If the screening method suggests hypoglycaemia, 62 of 63 neonatal paediatricians proceed to blood glucose determination in a laboratory, mostly using plasma samples. Based on the laboratory measurement, the definition of neonatal hypoglycaemia ranged from <1.1 to 3.0 mmol/L.
Conclusions : The majority of neonatal paediatricians in Australian NICU screen for neonatal hypoglycaemia using a bedside glucose meter. There is a wide range in the definition of neonatal hypoglycaemia from <1.1 to 3.0mmol/L. 相似文献
Methodology : A questionnaire was sent to the 101 neonatal paediatricians in the 22 Level 3 NICU in Australia asking their method of screening for, and definition of, neonatal hypoglycaemia.
Results : Responses were received from 70 neonatal paediatricians, including all 22 directors. A bedside glucose meter is used in 19 of 22 NICU to screen for hypoglycaemia, whilst one NICU uses a glucose analyzer and another NICU uses a visual colour comparison method. One NICU does not screen, but has blood glucose measured in a satellite laboratory. If the screening method suggests hypoglycaemia, 62 of 63 neonatal paediatricians proceed to blood glucose determination in a laboratory, mostly using plasma samples. Based on the laboratory measurement, the definition of neonatal hypoglycaemia ranged from <1.1 to 3.0 mmol/L.
Conclusions : The majority of neonatal paediatricians in Australian NICU screen for neonatal hypoglycaemia using a bedside glucose meter. There is a wide range in the definition of neonatal hypoglycaemia from <1.1 to 3.0mmol/L. 相似文献