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151.
Susana Helm Scott K Okamoto Jay Maddock Donald Hayes Tonya Lowery Ranjani Rajan 《Hawai'i Journal of Medicine & Public Health》2013,72(2):66-69
This article briefly outlines a collaboration among communities on Hawai‘i Island and a university-based research team to develop, implement, and evaluate a school-based substance use prevention curriculum called Ho‘ouna Pono. In addition to providing a rationale for the project, the goal of this paper is fourfold. First, an overview of the Ho‘ouna Pono research results to date (2007–2013) is provided. Second, within this overview, the ways in which selected results informed program development are highlighted. Third, the curriculum is briefly described, and finally, the role of the students and community in the video production is described. 相似文献
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The perspectives of stakeholders of intellectual disability liaison nurses: a model of compassionate,person‐centred care
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Palma Ann Marone William C. Hall A. Wallace Hayes 《Regulatory toxicology and pharmacology : RTP》2014
The 2-year rodent carcinogenicity test has been the regulatory standard for the prediction of human outcomes for exposure to industrial and agro-chemicals, food additives, pharmaceuticals and environmental pollutants for over 50 years. The extensive experience and data accumulated over that time has spurred a vigorous debate and assessment, particularly over the last 10 years, of the usefulness of this test in terms of cost and time for the information obtained. With renewed interest in the United States and globally, plus new regulations in the European Union, to reduce, refine and replace sentinel animals, this review offers the recommendation that reliance on information obtained from detailed shorter-term, 6 months rodent studies, combined with genotoxicity and chemical mode of action can realize effective prediction of human carcinogenicity instead of the classical two year rodent bioassay. The aim of carcinogenicity studies should not be on the length of time, and by obligation, number of animals expended but on the combined systemic pathophysiologic influence of a suspected chemical in determining disease. This perspective is in coordination with progressive regulatory standards and goals globally to utilize effectively resources of animal usage, time and cost for the goal of human disease predictability. 相似文献
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Peter Kalev Marc L. Hyer Stefan Gross Zenon Konteatis Chi-Chao Chen Mark Fletcher Max Lein Elia Aguado-Fraile Victoria Frank Amelia Barnett Everton Mandley Joshua Goldford Yue Chen Katie Sellers Sebastian Hayes Kate Lizotte Phong Quang Yesim Tuncay Katya Marjon 《Cancer cell》2021,39(2):209-224.e11
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Kristoffer Jarlov Jensen Victor Raúl Gómez Román Sanne Skov Jensen Christian Leo-Hansen Ingrid Karlsson Terese Lea Katzenstein Candida Medina Rodrigues Sanne Jespersen Christoph Mikkel Janitzek David da Silva Té Peter Hayes Anders Fomsgaard 《Clinical and Vaccine Immunology : CVI》2012,19(12):1999-2001