全文获取类型
收费全文 | 81005篇 |
免费 | 44788篇 |
国内免费 | 77篇 |
专业分类
耳鼻咽喉 | 1602篇 |
儿科学 | 4429篇 |
妇产科学 | 823篇 |
基础医学 | 16320篇 |
口腔科学 | 5336篇 |
临床医学 | 12910篇 |
内科学 | 24643篇 |
皮肤病学 | 7590篇 |
神经病学 | 13463篇 |
特种医学 | 2418篇 |
外国民族医学 | 1篇 |
外科学 | 14863篇 |
综合类 | 303篇 |
一般理论 | 28篇 |
预防医学 | 4732篇 |
眼科学 | 1544篇 |
药学 | 6306篇 |
中国医学 | 1089篇 |
肿瘤学 | 7470篇 |
出版年
2023年 | 130篇 |
2022年 | 284篇 |
2021年 | 1664篇 |
2020年 | 5297篇 |
2019年 | 11110篇 |
2018年 | 10427篇 |
2017年 | 11661篇 |
2016年 | 12308篇 |
2015年 | 12120篇 |
2014年 | 12133篇 |
2013年 | 12699篇 |
2012年 | 4641篇 |
2011年 | 4578篇 |
2010年 | 9221篇 |
2009年 | 5501篇 |
2008年 | 2419篇 |
2007年 | 1273篇 |
2006年 | 1226篇 |
2005年 | 978篇 |
2004年 | 944篇 |
2003年 | 899篇 |
2002年 | 971篇 |
2001年 | 889篇 |
2000年 | 806篇 |
1999年 | 378篇 |
1998年 | 82篇 |
1997年 | 53篇 |
1996年 | 60篇 |
1995年 | 58篇 |
1994年 | 60篇 |
1993年 | 37篇 |
1992年 | 81篇 |
1991年 | 71篇 |
1990年 | 82篇 |
1989年 | 66篇 |
1988年 | 66篇 |
1987年 | 64篇 |
1986年 | 65篇 |
1985年 | 53篇 |
1984年 | 42篇 |
1983年 | 24篇 |
1982年 | 24篇 |
1980年 | 24篇 |
1979年 | 31篇 |
1977年 | 29篇 |
1976年 | 26篇 |
1974年 | 17篇 |
1973年 | 18篇 |
1970年 | 22篇 |
1969年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 781 毫秒
181.
182.
Vincent Laville Sigrid Le Clerc Khaled Ezzedine Randa Jdid Lieng Taing Toufik Labib Cdric Coulonges Damien Ulveling Pilar Galan Christiane Guinot Leopold Fezeu Frdrique Morizot Julie Latreille Denis Malvy Erwin Tschachler Jean‐Franois Zagury 《Experimental dermatology》2019,28(8):892-898
Sagging eyelid is considered as an outward of skin ageing and may cause medical issues. However, little is known about the factors involved in sagging eyelid. The study, which aims at determining genetic risk factors for eyelid sagging, was conducted in a cohort of 502 unrelated Caucasian women living in the Paris region. All included participants were aged between 44 and 70 years old (mean age, 57.6 years old). The severity of sagging eyelid was graded in 6 categories by a dermatologist using standardized photographs of the face. A genome wide association study adjusted on potential risk factors (including age and smoking habits) was conducted to identify genetic associations. Two single nucleotide polymorphisms in total linkage disequilibrium on chromosome 10, rs16927253 (P = 7.07 × 10‐10) and rs4746957 (P = 1.06 × 10‐8), were significantly associated with eyelid sagging severity. The rs16927253‐T and rs4746957‐A alleles showed a dominant protective effect towards eyelid sagging. These polymorphisms are located in intronic parts of the H2AFY2 gene which encodes a member of the H2A histone family and very close to the AIFM2 gene that induces apoptosis. Additionally, single nucleotide polymorphisms with a false discovery rate below 0.25 were located nearby the type XIII collagen COL13A1 gene on chromosome 10 and in the ADAMTS18 gene on chromosome 16. Several relevant genes were identified by the genome wide association study for their potential role in the sagging eyelid severity. 相似文献
183.
184.
185.
186.
187.
188.
189.
Eduardo Rodrigues‐Pinto Joel Ferreira‐Silva Guilherme Macedo Douglas K. Rex 《Digestive endoscopy》2019,31(5):583-587
Cecal intubation is a critical aspect of effective, complete colonoscopy. Difficult colonoscopy is most often considered as one in which it is challenging or impossible to reach the cecum. It may be a common occurrence due to patient and/or endoscopist factors. Incomplete colonoscopies should be avoided, since patients in this context present an important prevalence of lesions that escape examination. The approach to successful cecal intubation should depend on characterization of the problem as redundant colon or difficult sigmoid colon. Most patients with a prior incomplete colonoscopy can be colonoscoped successfully, if careful attention is paid to technique, using a variety of scopes, colonoscopy methods and additional equipment. Sufficient time should be allotted to make the attempt. 相似文献
190.
Fardin Moradi Vahid Maleki Sevda Saleh‐Ghadimi Fatemeh Kooshki Bahram Pourghassem Gargari 《Clinical and experimental pharmacology & physiology》2019,46(11):975-983
Diabetes, as a low‐grade chronic inflammatory disease, causes disruption in proper function of immune and metabolic system. Chromium is an important element required for normal lipid and glucose metabolism. Chromium deficiency is correlated with elevation in cardiometabolic risk, which results from increased inflammation. This systematic review was conducted to discover the potential roles of chromium on inflammatory biomarkers. Eligible studies were all in vitro, animal and human studies published in English‐language journals from inception until October 2018. PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched to fined interventional studies from the effects of chromium on inflammatory biomarkers such as tumour necrosis factor a (TNF‐a), C‐reactive protein (CRP), interleukins, monocyte chemoattractant protein–1 (MCP‐1), intercellular adhesion molecule‐1 (ICAM‐1) and adipocytokines in hyperglycaemia and diabetes. Out of 647 articles found in the search, only 14 articles were eligible for analysis, three in vitro studies, eight animal studies and three human studies. Twelve of the 14 studies included in this review, chromium significantly decreased inflammatory factors. The findings of this review indicate, based on in vitro and in vivo studies, that chromium might have potential anti‐inflammatory properties, but some of the studies did not show anti‐inflammatory effects for chromium (two studies). There are only three studies in humans with controversial results. Therefore, more consistent randomized double‐blind controlled trials are needed to reach relevant clinical recommendations, as well as to determine the precise mechanism, of chromium on inflammation in diabetes. 相似文献