全文获取类型
收费全文 | 115339篇 |
免费 | 31571篇 |
国内免费 | 1130篇 |
专业分类
耳鼻咽喉 | 2741篇 |
儿科学 | 3273篇 |
妇产科学 | 2590篇 |
基础医学 | 4298篇 |
口腔科学 | 5509篇 |
临床医学 | 27543篇 |
内科学 | 28600篇 |
皮肤病学 | 3741篇 |
神经病学 | 12997篇 |
特种医学 | 4549篇 |
外国民族医学 | 1篇 |
外科学 | 21678篇 |
综合类 | 420篇 |
现状与发展 | 40篇 |
一般理论 | 15篇 |
预防医学 | 14118篇 |
眼科学 | 2859篇 |
药学 | 2846篇 |
中国医学 | 44篇 |
肿瘤学 | 10178篇 |
出版年
2024年 | 753篇 |
2023年 | 5178篇 |
2022年 | 1434篇 |
2021年 | 3561篇 |
2020年 | 5664篇 |
2019年 | 2682篇 |
2018年 | 7636篇 |
2017年 | 7789篇 |
2016年 | 8381篇 |
2015年 | 8497篇 |
2014年 | 11188篇 |
2013年 | 12981篇 |
2012年 | 5091篇 |
2011年 | 4822篇 |
2010年 | 7434篇 |
2009年 | 9672篇 |
2008年 | 4413篇 |
2007年 | 3266篇 |
2006年 | 4374篇 |
2005年 | 2791篇 |
2004年 | 2114篇 |
2003年 | 1673篇 |
2002年 | 1508篇 |
2001年 | 2363篇 |
2000年 | 1648篇 |
1999年 | 2127篇 |
1998年 | 2187篇 |
1997年 | 2002篇 |
1996年 | 2062篇 |
1995年 | 1807篇 |
1994年 | 1177篇 |
1993年 | 991篇 |
1992年 | 992篇 |
1991年 | 899篇 |
1990年 | 741篇 |
1989年 | 716篇 |
1988年 | 697篇 |
1987年 | 585篇 |
1986年 | 534篇 |
1985年 | 461篇 |
1984年 | 354篇 |
1983年 | 418篇 |
1982年 | 303篇 |
1981年 | 262篇 |
1980年 | 174篇 |
1979年 | 189篇 |
1978年 | 196篇 |
1977年 | 183篇 |
1974年 | 135篇 |
1973年 | 137篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
21.
22.
23.
24.
Well‐being,health and fitness of children who use wheelchairs: Feasibility study protocol to develop child‐centred ‘keep‐fit’ exercise interventions
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
25.
Interprofessional collaboration and communication in nursing homes: a qualitative exploration of problems in medical care for nursing home residents – study protocol
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
26.
The human visual system is amenable to a number of adaptive processes; one such process, or collection of processes, is the adaptation to blur. Blur adaptation can be observed as an improvement in vision under degraded conditions, and these changes occur relatively rapidly following exposure to blur. The potential important future directions of this research area and the clinical implications of blur adaptation are discussed. 相似文献
27.
Usha Patel Manish Pandey Sadhana Kannan Tanuja A. Samant Poonam Gera Neha Mittal Swapnil Rane Asawari Patil Vanita Noronha Amit Joshi Vijay M. Patil Kumar Prabhash Manoj B. Mahimkar 《British journal of cancer》2020,123(12):1757
Background Anti-EGFR-based therapies have limited success in HNSCC patients. Predictive biomarkers are greatly needed to identify the patients likely to be benefited from these targeted therapies. Here, we present the prognostic and predictive association of biomarkers in HPV-negative locally advanced (LA) HNSCC patients.Methods Treatment-naive tumour tissue samples of 404 patients, a subset of randomised Phase 3 trial comparing cisplatin radiation (CRT) versus nimotuzumab plus cisplatin radiation (NCRT) were analysed to evaluate the expression of HIF1α, EGFR and pEGFR by immunohistochemistry and EGFR gene copy change by FISH. Progression-free survival (PFS), locoregional control (LRC) and overall survival (OS) were estimated by Kaplan–Meier method. Hazard ratios were estimated by Cox proportional hazard models.Results Baseline characteristics of the patients were balanced between two treatment groups (CRT vs NCRT) and were representative of the trial cohort. The median follow-up was of 39.13 months. Low HIF1α was associated with better PFS [HR (95% CI) = 0.62 (0.42–0.93)], LRC [HR (95% CI) = 0.56 (0.37–0.86)] and OS [HR (95% CI) = 0.63 (0.43–0.93)] in the CRT group. Multivariable analysis revealed HIF1α as an independent negative prognostic biomarker. For patients with high HIF1α, NCRT significantly improved the outcomes [PFS:HR (95% CI) = 0.55 (0.37–0.82), LRC:HR (95% CI) = 0.55 (0.36–0.85) and OS:HR (95% CI) = 0.54 (0.36–0.81)] compared to CRT. While in patients with low HIF1α, no difference in the clinical outcomes was observed between treatments. Interaction test suggested a predictive value of HIF1α for OS (P = 0.008).Conclusions High HIF1α expression is a predictor of poor clinical response to CRT in HPV-negative LA-HNSCC patients. These patients with high HIF1α significantly benefited with the addition of nimotuzumab to CRT.Clinical trial registration Registered with the Clinical Trial Registry of India (Trial registration identifier—CTRI/2014/09/004980).Subject terms: Tumour biomarkers, Head and neck cancer, Tumour biomarkers, Head and neck cancer, Predictive markers 相似文献
28.
29.
30.
Quality of life in stroke survivor–caregiver dyads: a new conceptual framework and longitudinal study protocol
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)